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2000 articles
November 202624
Acceptability of a patient support and educational intervention for black breast cancer survivors.
This clinical trial evaluated the feasibility and acceptability of a six-week group support and education intervention for English-speaking Black women who had survived stage I–III breast cancer diagnosed within the…
Safety, Biodistribution, and Dosimetry of FAP and Integrin α v β 3 Dual-Targeting Radioligand 177 Lu-DOTA-FAPI-RGD: Preclinical Validation and First-in-Human Study in Patients with Advanced Adenocarcinomas.
This phase I, first-in-human study evaluated the safety, biodistribution, dosimetry, and preliminary efficacy of the dual-targeting radioligand 177Lu-LNC1009 in nine patients with advanced solid tumors and positive…
Proteomic and Metabolomic Profiling in Moyamoya Disease: A Systematic Review.
This systematic review examined human studies using high-throughput proteomic or metabolomic methods on serum or cerebrospinal fluid in Moyamoya disease (MMD). Of 3,071 records identified, 31 studies were included.
Effect of Blonanserin on Neurotrophic Factors in Patients With Non-Responsive First-Episode Schizophrenia Treated With Early Risperidone Monotherapy-A Randomized Controlled Trial.
This randomized controlled trial compared blonanserin with clozapine over 3 months in 120 hospitalized patients with first-episode schizophrenia who had not responded to early risperidone monotherapy.
Multikinase Inhibition with Tinengotinib in Advanced Solid Tumors: Results from a Multicenter Phase Ib/II Trial.
This multicenter phase Ib/II trial evaluated tinengotinib’s safety, pharmacokinetics, antitumor activity, and genomic correlates in patients with advanced or metastatic solid tumors lacking standard treatment options.
Breast Adenomyoepithelioma with Malignant Changes in a 36-year-old Female: Clinicopathological, Histomorphological and Therapeutic Considerations.
A woman described in the abstract as 360 years old presented with an asymptomatic left breast tumour measuring 2.5 cm × 2.0 cm × 0.8 cm.
RELAX Perinatal Digital Intervention to Prevent Increasing Anxiety: A Randomized Clinical Trial.
This multisite, phase 2b randomized clinical trial tested whether a self-led, pregnancy-tailored digital cognitive bias modification intervention added to usual maternity care could prevent rising anxiety in pregnant…
A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer.
This single-center phase II trial evaluated pembrolizumab plus GM-CSF in 42 patients with advanced biliary cancers previously treated with chemotherapy and without prior immune checkpoint inhibitor therapy.
Caring Contacts and Suicidality Among American Indian and Alaska Native Communities: A Randomized Clinical Trial.
The CARE study was a blinded, two-group randomized clinical trial of 709 American Indian and Alaska Native adults with active suicidality across five communities.
Tetracaine hydrochloride gel delays and reduces catheter-related bladder discomfort after transurethral resection: a randomized controlled trial.
This randomized, single-blind trial compared tetracaine hydrochloride gel with standard lubricant in 130 patients undergoing transurethral resection.
Orthoplastic Limb Salvage Using Transtibial Transport and Free-Flap Reconstruction in Patients With Diabetes-Related Chronic Limb-Threatening Ischemia.
A 56-year-old man with poorly controlled diabetes and severe peripheral arterial disease developed a chronic foot ulcer with toe gangrene despite unsuccessful revascularization, leaving no conventional revascularization…
Selective Electrical Muscle Stimulation of the Vastus Medialis in a Patient With Knee Osteoarthritis, With Changes in Muscle Quality, Symptoms, and Physical Activity: A Case Report.
A 77-year-old man with Kellgren-Lawrence grade 2 right knee osteoarthritis had stopped regular exercise, including aquatic walking, because of knee pain.
Early Metformin Initiation and Glycemic Outcomes in Gestational Diabetes: A Secondary Analysis of a Randomized Clinical Trial.
This secondary analysis of a double-masked, placebo-controlled randomized clinical trial assessed early metformin versus placebo, alongside usual care, in pregnancies complicated by gestational diabetes at two Irish…
Prognostic value of Murray law-based quantitative flow ratio after percutaneous coronary intervention.
This prespecified subgroup analysis of the randomised FAVOR III China trial assessed whether post-PCI Murray law-based quantitative flow ratio (μQFR) was associated with long-term outcomes.
Adjunctive neodymium-doped yttrium aluminum garnet laser therapy for periodontitis in type 2 diabetes: A randomized controlled trial.
This randomized controlled trial compared conventional nonsurgical periodontal therapy with or without adjunctive neodymium-doped yttrium aluminum garnet laser therapy in 120 patients with periodontitis and type 2…
Primary Endocrine Therapy vs Upfront Surgery for Older Women With Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared primary endocrine therapy (pET) with upfront surgery for operable, nonmetastatic, estrogen receptor-positive breast cancer in older women.
A Scalable Teacher Professional Development and Wellness Program in Primary Schools: A Cluster Randomized Clinical Trial.
This cluster randomized clinical trial evaluated professional development (PD), with or without a teacher-wellness enhancement (PDT), in 47 urban and rural primary schools in Uganda.
Short-term bioavailability of EPA and DHA from an algae oil-fortified soymilk compared with algae oil capsules.
This 4-week, open-label, randomized parallel trial compared short-term EPA and DHA bioavailability from algae oil-fortified soymilk with algae oil capsules in 21 healthy adults.
Tuberculous meningoencephalitis in a heart transplant recipient: a case report.
A 33-year-old heart transplant recipient receiving immunosuppression developed headache, fever, and focal neurological signs after a complicated admission that included an incidental miliary pulmonary pattern on chest…
Leptomeningeal carcinomatosis arising from esophageal cancer: a systematic review of the literature.
This systematic review synthesized 31 studies describing 43 patients with leptomeningeal carcinomatosis arising from esophageal cancer.
Role of magnesium as a protective agent in cisplatin-induced nephrotoxicity in head and neck cancer.
This randomized controlled trial evaluated intravenous magnesium sulfate for prevention of cisplatin-induced nephrotoxicity in 100 newly diagnosed patients with head and neck squamous cell carcinoma receiving concurrent…
Dapagliflozin attenuates progression from prefrailty to frailty in patients with hypertension and chronic kidney disease.
DAPA-FORTRESS followed prefrail hypertensive adults aged over 65 years with chronic kidney disease (CKD) for 1 year to examine links between renal measures and physical performance, and whether dapagliflozin was…
Proton-pump inhibitor-induced severe hypomagnesemia presenting with seizure and functional hypoparathyroidism: A diagnostic challenge in long-term acid suppression therapy.
A 68-year-old man taking omeprazole 40 mg/day for 8 years presented with a generalized tonic-clonic seizure and neuromuscular irritability.
Pearls & Oy-sters: The Price of Patency: Intractable Headache Subsequent to Fourth Ventricular Recanalization.
A 61-year-old woman with secondary fourth ventricular hemorrhage was treated using an IRRAflow active irrigation and drainage system.
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