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541 articles
November 202624
Thrombocytapheresis for Extreme Thrombocytosis: A 20-Year Single-Center Experience With Acute and Chronic Use in Myeloproliferative Neoplasms.
Thrombocytapheresis is an established adjunctive therapy for rapid platelet cytoreduction in patients with extreme thrombocytosis, particularly in myeloproliferative neoplasms (MPNs), where it is typically used…
Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.
This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.
Physiological prehabilitation for patients undergoing cellular therapy in multiple myeloma and lymphoma: a systematic review.
This systematic review examined exercise-based physiological prehabilitation in adults with multiple myeloma or lymphoma before cellular or immune-based therapy.
Efficacy and safety of apixaban versus rivaroxaban in acute venous thromboembolism: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis compared apixaban with rivaroxaban for acute venous thromboembolism in adults.
Individualizing Apheresis Processing Volumes Using a Predictive Algorithm: Analysis of the CAR T-Cell Collection Protocol Utilized in ACIT001/EXC002, a Phase Ib/II Trial of Decentralized Production of CAR T Cells for Treatment of Relapsed/Refractory Aggressive NHL and ALL.
This analysis of the CAR T-cell collection protocol used in the phase Ib/II ACIT001/EXC002 trial examined individualized blood-volume processing for patients with relapsed or refractory non-Hodgkin lymphoma or acute…
Efficacy and safety of the cladribine, idarubicin, and cytarabine regimen for treating acute myeloid leukemia: a systematic review and single-arm meta-analysis.
This systematic review and single-arm meta-analysis assessed the efficacy and safety of cladribine, idarubicin, and cytarabine (CIA) for acute myeloid leukemia (AML), separating newly diagnosed (ND) from…
Multiorgan [ 18 F]florbetapir PET/CT uptake in multiple myeloma-associated systemic AL amyloidosis: a case report.
A 77-year-old man with multiple myeloma underwent whole-body [18F]florbetapir PET/CT because AL amyloidosis was suspected. The scan showed prominent tracer retention in the myocardium, thyroid, lungs, parotid glands…
Postpartum-acquired hemophilia A presenting as a recurrent rectus sheath hematoma following cesarean section: a case report.
A 30-year-old woman presented 17 days after an uncomplicated second cesarean section with severe abdominal pain and a rectus sheath hematoma.
Triple immune impairment in an elderly patient with IgG4-AIP and MGUS complicated by dual severe infections over 3 years: A case report.
An 82-year-old man with IgG4-related autoimmune pancreatitis and IgGλ monoclonal gammopathy of undetermined significance had markedly elevated serum IgG4 and a monoclonal paraprotein at baseline.
IgD-λ POEMS syndrome presenting with edema, pulmonary hypertension, and renal impairment: A case report.
A 38-year-old woman presented with years of intermittent leg edema, elevated creatinine, and acute worsening, followed by precapillary pulmonary hypertension, polyserous effusions, splenomegaly, lymphadenopathy, anemia…
Assay-aware flow-cytometric interpretation of relapsed B-cell precursor acute lymphoblastic leukemia after sequential CD19- and CD22-directed therapy: A case report.
A 73-year-old woman with B-cell precursor acute lymphoblastic leukemia developed marrow relapse after blinatumomab exposure.
Delayed pancytopenia following ingestion of wild mushrooms consistent with Hypholoma fasciculare: A case report.
A 57-year-old man presented with fever and generalized weakness about 10 days after eating self-collected wild mushrooms consistent with Hypholoma fasciculare. Testing showed delayed-onset pancytopenia.
Tranexamic acid for anemia in women of reproductive age: A systematic review of randomized trials.
This systematic review and meta-analysis assessed randomized trials of tranexamic acid (TXA) versus placebo or standard care for uterine bleeding in women of reproductive age.
A case report of ultra-rare SMARCD2 deficiency and review of the literature.
The report describes a patient with congenital neutropenia due to specific granule deficiency type 2, a syndromic autosomal recessive disorder associated with loss-of-function variants in SMARCD2.
Sirolimus-induced improvement of immune dysregulation associated hepatosplenomegaly in common variable immunodeficiency: a case-based review.
A 50-year-old woman with common variable immunodeficiency (CVID), treated with regular intravenous immunoglobulin replacement, developed progressive hepatosplenomegaly, cytopenias, abdominal enlargement, dyspnea…
Combining quizartinib with intensive chemotherapy for older patients with newly diagnosed AML: results of the UK NCRI AML18 trial.
The multicentre randomised UK NCRI AML18 trial evaluated quizartinib after intensive chemotherapy, with or without maintenance, in patients older than 60 years with newly diagnosed AML or high-risk myelodysplastic…
Pseudo-Metabolic Alkalosis: A Hidden Laboratory Pitfall With Elevated LDH.
A 33-year-old man presented with progressive exertional dyspnea, syncope, and paresthesia. Testing showed pancytopenia, macrocytosis, LDH >3600 U/L, low haptoglobin, and vitamin B₁₂ <68 pg/mL, consistent with pernicious…
Zanubrutinib, obinutuzumab, and venetoclax in CLL: long-term follow up, MRD kinetics, retreatment, T-cell profiling, and PKs.
This phase 2 trial evaluated an MRD-guided course of zanubrutinib, obinutuzumab, and venetoclax (BOVen) in treatment-naïve chronic lymphocytic leukemia, including assessment of zanubrutinib–venetoclax retreatment and…
"Fatal venous thromboembolism and divergent phenotypes in DOCK8 deficiency: a three-sibling case series".
Three siblings with genetically confirmed DOCK8 deficiency had early-onset atopic dermatitis, recurrent respiratory infections, and failure to thrive. All developed bronchiectasis and severe viral infections.
TIM3 Blockade with Hypomethylating Therapy Restores NK Cell and Cytotoxic CD4+ T-cell Activity in Patients with AML or MDS.
This phase Ib clinical trial examined immune changes in patients with AML or MDS treated with anti-TIM3 sabatolimab plus decitabine.
Acquired haemophilia B in Kyasanur Forest disease: a case series of isolated prolonged activated partial thromboplastin time.
Nine patients with confirmed acute Kyasanur Forest disease had prolonged activated partial thromboplastin time (APTT) with normal prothrombin time.
Phase 1/2 trial of Evomela for autologous transplant in myeloma: schedule optimization and matched comparison with MEL200.
This prospective, randomized phase 1/2 trial evaluated Evomela dose and infusion schedule in 60 patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation.
Effects of extremely low-volume high-intensity interval training combined with iron supplementation versus iron supplementation alone on postural control in young women with iron deficiency anemia: a randomized controlled trial.
This randomized controlled trial compared 8 weeks of extremely low-volume, plyometric-based high-intensity interval training (HIIT) plus oral iron with iron supplementation alone in young women aged 18–25 years with…
A comparison of the efficacy and safety of direct oral anticoagulants with low molecular weight heparin for venous thromboembolism prophylaxis after total hip arthroplasty : a systematic review and meta-analysis.
This systematic review and meta-analysis compared direct oral anticoagulants (DOACs) with low molecular weight heparin (LMWH) for venous thromboembolism prophylaxis after elective total hip arthroplasty.
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