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2000 articles
October 202624
Safety and immunogenicity of a first-generation modified vaccinia virus Ankara-vectored SARS-CoV-2 vaccine candidate with mRNA-based booster vaccination: A phase 1 trial.
This phase 1 trial assessed safety and immune responses to the MVA-vectored SARS-CoV-2 vaccine MVA-SARS-2-S in 30 healthy, SARS-CoV-2-naive adults given two doses 28 days apart, with six-month follow-up.
Psychoeducational interventions for children and adolescents with potentially traumatic experiences: a systematic review.
This systematic review examined stand-alone psychoeducational interventions for children and adolescents exposed to potentially traumatic experiences, including interventions delivered directly or through caregivers.
The impact of prophylactic azithromycin on the developing preterm gut microbiome and resistome.
This multicentre, double-blind, randomised, placebo-controlled trial examined the effects of 10 days of prophylactic intravenous azithromycin on the gut microbiome and resistome of 693 preterm infants born before 30…
Modulation of the gut microbiome and resistome by antibiotic use, but not by subsequent 2'-fucosyllactose intake, in adults with overweight or obesity.
This randomized, double-blind, placebo-controlled intervention examined gut microbiome and resistome changes in 18 adults with overweight or obesity after seven days of vancomycin, followed by eight weeks of…
Short-term Rhodiola rosea supplementation improves premenstrual symptoms, reaction time, and perceived exertion in female taekwondo athletes: a randomised double-blind placebo-controlled trial.
This randomised, double-blind, placebo-controlled trial tested 10 days of Rhodiola rosea (RR) supplementation during the estimated symptomatic premenstrual phase in 24 female taekwondo athletes with moderate-to-severe…
Multimodal assessment of exceptional responders refines subtyping-directed precision treatment in HR+/HER2- breast cancer.
This clinical-trial analysis examined whether multimodal tumour and clinical features could clarify exceptional responses to subtype-directed treatment in locally advanced HR+/HER2− breast cancer.
Effect of Previsit AI-Generated Document Summaries on Consultation Time and Patient-Physician Communication - The AI-INFOCARE Randomized Controlled Trial.
This single-center randomized controlled trial evaluated whether a quality-checked, AI-generated lay summary of medical findings before outpatient neurosurgical consultations affected communication and consultation…
Association of immune checkpoint-related polymorphisms in PD-1, PD-L1, and CTLA-4 genes with susceptibility to genitourinary cancer: a meta-analysis.
This meta-analysis pooled evidence from 16 case-control studies examining six single-nucleotide polymorphisms in PD-1, PD-L1, and CTLA-4 genes and susceptibility to genitourinary cancers, including urothelial, renal…
AI-Based Pathology Classifier Predicts Sensitivity to Enzalutamide in Metastatic Hormone-Sensitive Prostate Cancer: A Biomarker Analysis of the ENZAMET Trial.
This prespecified biomarker analysis of the randomised ENZAMET trial assessed whether a locked artificial intelligence pathology image classifier (APIC) identified differential overall-survival benefit from enzalutamide…
Efficacy and Safety of Enlicitide in Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and random-effects meta-analysis assessed efficacy and safety of oral enlicitide in adults with hypercholesterolemia.
Safety, Tolerability and Antiviral Activity of GST-HG131 in Chronic Hepatitis B: A Randomized, Double-Blind Phase IIa Study.
This randomized, double-blind, placebo-controlled Phase IIa trial assessed oral GST-HG131 in 45 adults with chronic hepatitis B receiving nucleos(t)ide analogue monotherapy.
The effect of three- and six-session prenatal haptonomy on pregnancy-related anxiety, distress, and psychological well-being: A randomized controlled trial.
This randomized controlled trial assigned 102 pregnant women to three-session prenatal haptonomy, six-session haptonomy, or routine antenatal care.
Prevalence of urinary incontinence among women in Turkey: A systematic review and meta-analysis.
This systematic review and meta-analysis estimated urinary incontinence (UI) prevalence among women in Türkiye. It included 45 studies published between 2005 and 2025, with 41,038 participants.
Effects of glucagon-like peptide-1 (GLP-1) mono-agonists on reward processing in animal models: a systematic review.
This systematic review synthesised 66 preclinical studies of GLP-1 and GLP-1 receptor mono-agonists in animal models, examining food-, drug- and sexual-related reward.
The psychological experience of body image change in adult stoma patients: A systematic review and qualitative meta-synthesis.
This systematic review and qualitative meta-ethnography synthesised English-language qualitative research on body image change in adults with a stoma. Eighteen studies involving 602 participants were included.
Viral interference with SARS-CoV-2 during the COVID-19 pandemic: An individual participant data meta-analysis.
This individual participant data meta-analysis examined whether SARS-CoV-2 co-occurred with other respiratory viruses in ten cohort studies conducted during 2020–2024.
Robotic selective thoracic sympathectomy for hyperhidrosis: refined technique and anatomical variation.
Primary hyperhidrosis substantially impairs quality of life. Conventional sympathectomy risks compensatory hyperhidrosis through trunk disruption, whilst selective sympathectomy preserves the trunk while dividing…
Endoscopic secondary chordae transfer and edge-to-edge repair for the treatment of asymmetric anterior leaflet prolapse.
A 59-year-old patient with Barlow’s disease presented with severe mitral regurgitation from asymmetric anterior leaflet prolapse.
Ramadan Fasting in Chronic Heart Failure: A Systematic Review.
This systematic review assessed clinical studies of Ramadan fasting in people with chronic heart failure. Searches of PubMed, Scopus, and Web of Science identified seven eligible studies from 137 records; most were…
Severe growth retardation in Dent disease: a case report of a novel OCRL variant.
A 12-year-old boy with marked short stature and poor weight gain had low-molecular-weight proteinuria, haematuria, hypercalciuria and bilateral nephrocalcinosis, with normal renal function and no relevant family…
A comprehensive review of European clinical practice guidelines on psychological and cognitive assessment and support for cancer patients and their families.
This systematic review mapped European clinical practice guidelines and recommendations published in the preceding 15 years on psychological and cognitive assessment and support for people with cancer and their…
Dietary and lifestyle quality and endometrial cancer: Incidence and survivorship outcomes-An umbrella review of systematic reviews and meta-analyses.
This umbrella review of 21 systematic reviews, including meta-analyses, assessed composite diet and lifestyle quality in relation to endometrial cancer (EC) risk and survivorship outcomes.
Perineural versus intravenous dexmedetomidine as an adjuvant for ilioinguinal/iliohypogastric nerve block in open inguinal hernia repair: a randomised controlled trial.
This single-centre, triple-blind randomised controlled trial compared perineural, intravenous and placebo dexmedetomidine as adjuncts to an ilioinguinal/iliohypogastric nerve block in 90 adults undergoing elective open…
Exploring the landscape of flagellate erythema as a rare cutaneous symptom of idiopathic inflammatory myopathy: a case series-based review.
Two patients with idiopathic inflammatory myopathy developed zebra-like flagellate erythema: one had immune-mediated necrotising myopathy and the other anti-Mi-2-positive cancer-associated myositis.
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