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2000 articles

October 202624

Clinical ResearchVascular SurgeryOpen access

Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.

This prespecified cognitive-outcomes analysis of the multicentre, randomised CREST-2 trials assessed patients aged 35 years or older with at least 70% asymptomatic carotid stenosis.

JAMAOct 27, 2026Read summary
Clinical ResearchDermatology

The follicular microbiome in hair-follicle-associated inflammatory diseases: a systematic review.

This systematic review qualitatively synthesized culture-independent studies of the bacterial hair-follicle microbiome in inflammatory hair-follicle-associated diseases.

Clin Exp DermatolOct 27, 2026Read summary
Clinical ResearchNeurology

Measuring the impact of migraine: a systematic review of the measurement properties of MIDAS, HIT-6, and MSQoL.

This systematic review compared the measurement properties of MIDAS, HIT-6, and MSQoL for assessing migraine impact. Following COSMIN methods, it included 22 studies with 20,455 participants.

Arq NeuropsiquiatrOct 27, 2026Read summary
Clinical ResearchInfectious Diseases

Next-Generation Bed Nets to Control Malaria in Côte d'Ivoire.

This cluster-randomized clinical trial compared pyrethroid-only long-lasting insecticidal nets with piperonyl butoxide-pyrethroid (PBO-py) and chlorfenapyr-pyrethroid (CFP-py) nets in villages in Côte d'Ivoire.

NEJM EvidOct 27, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Exposure to natural disasters and vaccination indicators: a systematic review and directions for future research.

This systematic review examined peer-reviewed research on exposure to natural disasters and vaccination indicators, including vaccine administration, coverage, and rates.

VaccineOct 27, 2026Read summary
Clinical ResearchPediatricsOpen access

Permissive Blood Pressure Targets in Pediatric Critical Care: The PRESSURE Randomized Clinical Trial.

The multicenter, unblinded pragmatic randomized PRESSURE trial compared a permissive mean arterial pressure (MAP) target (greater than the fifth percentile for age) with usual physician-set targets in hypotensive…

JAMAOct 27, 2026Read summary
Clinical ResearchOncology (Medical)

Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.

DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…

Lancet OncolOct 27, 2026Read summary
Clinical ResearchInfectious DiseasesOpen access

Rare and Novel Hepatitis C Virus Genotype Subtypes and Response to Sofosbuvir/Velpatasvir in A5360 (MINMON) Clinical Trial.

This analysis of samples from the multicountry ACTG A5360 (MINMON) clinical trial characterized rare and novel hepatitis C virus (HCV) subtypes and assessed baseline resistance-associated substitutions and response to…

J Viral HepatOct 27, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effect of Adding Esketamine to Patient-Controlled Intravenous Analgesia on Rebound Pain After Interscalene Brachial Plexus Block: A Randomized Controlled Trial.

This randomized controlled trial evaluated whether adding esketamine to postoperative patient-controlled intravenous analgesia (PCIA) reduces rebound pain after interscalene brachial plexus block in patients undergoing…

Drug Des Devel TherOct 27, 2026Read summary
Case ReportPulmonology

Two Older Adult Patients With Anorexia and Cachexia Following Refractory Mycobacterium avium-intracellulare Complex Pulmonary Disease Given Acupuncture Treatment to Improve Appetite and Food Intake.

Two older adults with refractory cavitary Mycobacterium avium-intracellulare complex pulmonary disease developed severe anorexia, dyspnea associated with eating, and cachexia.

Am J Case RepOct 27, 2026Read case
Clinical ResearchPreventive Medicine / Public Health

E-Cigarettes with and without Behavioral Support for Smoking Cessation.

This randomized controlled trial compared an e-cigarette starter pack alone, the starter pack plus multisession telephone-based behavioral support, and automated supportive messages among people who smoked and were…

NEJM EvidOct 27, 2026Read summary
Clinical ResearchPsychiatry

Combining Cognitive Training and Brain Stimulation: A Novel Approach to Address Disordered Eating and Antipsychotic-Induced Weight Gain in People With Severe Mental Illness.

This double-blind, parallel-group, sham-controlled randomised trial assessed the feasibility of combining Approach Bias Modification Training (ABMT) with real or sham transcranial direct current stimulation (tDCS) in…

Early Interv PsychiatryOct 27, 2026Read summary
Clinical ResearchPulmonology

Comparison of the Safety and Efficacy of Remimazolam for Sedation in Adults Undergoing Fiberoptic Bronchoscopy: A Meta-Analysis of Randomized Controlled Trials.

This systematic review and meta-analysis of randomized controlled trials compared remimazolam with other sedatives in adults undergoing fiberoptic bronchoscopy.

J Bronchology Interv PulmonolOct 27, 2026Read summary
Clinical ResearchPediatrics

Endobronchial Valves for Persistent Air Leak and Bronchopleural Fistula in Children: A Systematic Review of Indications, Procedural Approaches, and Outcomes.

This systematic review examined bronchoscopic endobronchial or intrabronchial valve placement for persistent air leak, bronchopleural fistula, or pneumothorax with ongoing air leak in children and late adolescents.

J Bronchology Interv PulmonolOct 27, 2026Read summary
Clinical ResearchInfectious Diseases

Measles transmission-related epidemiological parameter estimates: a systematic review and meta-analysis.

This systematic review and meta-analysis synthesized English- and French-language primary studies reporting measles transmission-related epidemiological parameters, identified through 14 May 2024.

Epidemiol InfectOct 27, 2026Read summary
Clinical ResearchInfectious Diseases

Hemagglutinin- and neuraminidase-targeting antibody responses after receipt of egg-based inactivated or recombinant influenza vaccines among adults aged 18-64 years.

This randomized trial compared hemagglutinin (HA)- and neuraminidase (NA)-targeting antibody responses after 2022–2023 recombinant influenza vaccine (RIV) or standard-dose inactivated influenza vaccine (SD-IIV) in…

VaccineOct 27, 2026Read summary
Case ReportInfectious Diseases

Isolated Disturbance of Consciousness as Initial Presentation of Staphylococcus aureus Endocarditis: A Case Report With Brief Literature Review.

A man in his 50s presented with isolated disturbance of consciousness and no reported fever, although his admission temperature was 38°C.

Am J Case RepOct 27, 2026Read case
Case ReportObstetrics & Gynecology

Vaginal Angiomyofibroblastoma in a Patient With Warkany Syndrome (Mosaic Trisomy 8): A Case Report.

A 27-year-old nulliparous woman with constitutionally confirmed mosaic trisomy 8 presented with a protruding vaginal mass. MRI showed a well-defined, homogeneously enhancing mid-vaginal lesion and incidentally…

J Obstet Gynaecol ResOct 27, 2026Read case
Clinical ResearchGeneral Surgery

Associating liver partition and portal vein ligation for staged hepatectomy procedure versus conventional two-stage hepatectomy for colorectal liver metastasis.

This Cochrane systematic review and meta-analysis assessed ALPPS versus conventional two-stage hepatectomy in adults with colorectal liver metastases and an estimated future liver remnant below 30% of total liver…

Cochrane Database Syst RevOct 27, 2026Read summary
Clinical ResearchPediatrics

Air versus supplemental oxygen for resuscitation of term or late preterm infants at birth.

This Cochrane systematic review and meta-analysis assessed randomised and quasi-randomised trials comparing air with supplemental oxygen for resuscitation at birth in term and late preterm infants needing respiratory…

Cochrane Database Syst RevOct 27, 2026Read summary
Clinical ResearchUrologyOpen access

Robot-assisted versus open partial nephrectomy in patients with a solitary kidney: a systematic review and meta-analysis of perioperative and functional outcomes.

This systematic review and meta-analysis compared robot-assisted partial nephrectomy (RAPN) with open partial nephrectomy (OPN) for tumors in a solitary kidney.

J Robot SurgOct 27, 2026Read summary
Clinical ResearchOrthopedic SurgeryOpen access

Closed percutaneous reduction versus mini-open sinus tarsi approach for fixation of displaced intra-articular calcaneal fractures: a systematic review and meta-analysis.

This systematic review and meta-analysis compared closed percutaneous reduction (PR) with the mini-open sinus tarsi approach (STA) for acute displaced intra-articular calcaneal fractures.

Eur J Orthop Surg TraumatolOct 27, 2026Read summary
Clinical ResearchPsychiatry

Psychedelics and psychosis: A systematic review of recent-era studies (1984-2025).

This systematic review examined evidence from 1984–2025 on classical psychedelic use and psychotic symptoms, drawing on 52 papers, including population studies, clinical trials, emergency and toxicology data, and case…

J PsychopharmacolOct 27, 2026Read summary
Clinical ResearchObstetrics & GynecologyOpen access

Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial.

This multicentre, double-blind, randomised, placebo-controlled trial tested intrauterine mepivacaine before IUD placement in nulliparous individuals aged 18 to 31 years at 11 Swedish clinics.

JAMAOct 27, 2026Read summary

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