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2000 articles
November 202624
Primary Endocrine Therapy vs Upfront Surgery for Older Women With Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared primary endocrine therapy (pET) with upfront surgery for operable, nonmetastatic, estrogen receptor-positive breast cancer in older women.
Sunlight Exposure and Breast Cancer Risk: A Systematic Review and Meta-analysis.
This systematic review and random-effects meta-analysis combined 31 epidemiologic studies to assess sunlight exposure and breast cancer incidence, subtype, and survival.
Effects of Dual-Task Training With and Without Backward Walking on Balance, Functional Mobility, and Participation in Ambulatory Children With Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial.
This randomized controlled trial compared dual-task training (DTT) with DTT incorporating backward walking (BW) in 44 ambulatory children aged 6–12 years with spastic diplegic cerebral palsy (GMFCS I–II).
Optimizing the Therapeutic Index: Sequential Intraarterial-Intravenous PRRT with Personalized Volumetric-Adjusted Dosing.
This prospective clinical trial assessed a personalized sequence of intraarterial then intravenous 177Lu-DOTATATE in 10 adults with progressive, nonresectable, liver-dominant metastatic gastroenteropancreatic…
Proteomic and Metabolomic Profiling in Moyamoya Disease: A Systematic Review.
This systematic review examined human studies using high-throughput proteomic or metabolomic methods on serum or cerebrospinal fluid in Moyamoya disease (MMD). Of 3,071 records identified, 31 studies were included.
Fucoidan as an anti-inflammatory and immunomodulatory agent in humans: a systematic review of clinical evidence and translational potential.
This systematic review assessed human interventional studies of fucoidan supplementation for inflammatory, immune, metabolic, and tumour-related outcomes.
Prognostic value of the systemic inflammation response index (SIRI) in glioma: A meta-analysis.
This meta-analysis assessed whether the systemic inflammation response index (SIRI) predicts outcomes in patients with glioma. It pooled evidence from eight retrospective cohort studies involving 1,778 patients.
The Effect of Perioperative Video Interventions on Postoperative Pain Control: A Systematic Review.
This systematic review examined randomized controlled trials of perioperative video interventions in adult surgical patients, assessing postoperative pain intensity and analgesic consumption.
Pearls & Oy-sters: The Price of Patency: Intractable Headache Subsequent to Fourth Ventricular Recanalization.
A 61-year-old woman with secondary fourth ventricular hemorrhage was treated using an IRRAflow active irrigation and drainage system.
Pharmacological treatment of bereavement-related distress: a systematic review.
This systematic review assessed pharmacological treatments for bereavement-related psychological distress, including depression following bereavement.
An Approach to Acute Cranial Symptoms in Primary Care: Lesson From a Case of Miller Fisher Syndrome.
A 38-year-old woman developed acute diplopia, right eye pain, headache, and perioral numbness two weeks after an upper respiratory infection.
Clinical effectiveness and safety of bacterial cellulose dressings in the management of skin wounds: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of bacterial cellulose dressings compared with conventional treatments for skin wounds.
Effect of topical insulin in diabetic foot ulcer healing among patients with diabetes in Asia: a systematic review.
This systematic review assessed topical insulin for diabetic foot ulcer healing in patients with diabetes in Asian countries.
Neoadjuvant Nivolumab plus Carboplatin and Paclitaxel in Patients with Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck: A Phase II, Single-Arm Trial.
This single-arm, open-label phase II trial evaluated neoadjuvant nivolumab plus carboplatin and paclitaxel in patients with newly diagnosed, locally advanced, resectable head and neck squamous cell carcinoma, including…
Father-Daughter Autosomal Recessive Gitelman Syndrome Caused by Compound Heterozygous Variants in the SLC12A3 Gene.
A Chinese father and daughter were found to have Gitelman syndrome, a kidney tubular disorder associated with pathogenic SLC12A3 variants.
Pilot Implementation of an Adapted Online Clinic-Community Model for Childhood Obesity.
This two-arm randomized controlled trial assessed feasibility, acceptability, and preliminary effectiveness of an adapted online family-based clinic-community intervention for children aged 4 to < 8 years with…
Sleep Management and Recovery After TBI in Kids (SMART-Kids): Pilot Trial Using Melatonin.
This pilot randomized, double-blinded, placebo-controlled trial assessed early melatonin plus sleep education in children aged over 6 to 18 years hospitalized after traumatic brain injury (TBI).
Emergency management of obturator hernıa in elderly patients: A case series and surgical strategy.
Three elderly, cachectic women presented with symptoms and signs of mechanical intestinal obstruction. CT imaging identified obturator hernias, and all underwent emergency surgery.
Severe acute gastric volvulus: A case report with perforation and extra-gastric ischemic findings.
A 36-year-old man presented with sudden abdominal distension and respiratory distress, with severe hemodynamic instability and an acute abdomen. Imaging showed intraperitoneal free air, leading to emergency laparotomy.
Recurrent Cardiac Cephalalgia: A Case Report and Pooled Narrative Review.
An elderly man with multiple cardiovascular risk factors and prior coronary artery disease treated with percutaneous coronary intervention had progressive exertional headaches over several years, without typical cardiac…
ChatGPT and Other Large Language Models in Inflammatory Arthritis: A Systematic Review Across Clinical Tasks.
This systematic review assessed large language model performance across clinical tasks in inflammatory arthritis. It included 18 studies spanning rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, gout…
Phase 1 Evaluation of the Pharmacokinetics of Sevasemten (EDG-5506) for Potential Food Effect and Drug-Drug Interaction With a CYP3A4 Moderate Inhibitor.
This Phase 1, open-label, parallel study assessed the pharmacokinetics of sevasemten in healthy subjects across three cohorts: sevasemten alone while fasted, with verapamil, and after a high-fat meal.
European Guidelines on Multidisciplinary Management of Obstructed Defecation Syndrome-ESCP, UEG, ESGAR, EAGEN, ESGENA, ESNM and ESPCG.
These European multidisciplinary practice guidelines address diagnosis and management of obstructed defecation syndrome (ODS).
Transformation to Small-Cell Lung Carcinoma and Then to Sarcomatoid Carcinoma in an EGFR-Mutant Lung Adenocarcinoma Patient During Systemic Therapy: A Case Report.
A patient with EGFR-mutant lung adenocarcinoma developed resistance to osimertinib with transformation to combined small-cell lung carcinoma.
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