Multiple Bone Metastases Exhibiting Exceptionally High 18 F-MFBG Uptake Exceeding Physiological Bladder Activity in a Patient With Neuroblastoma.

Clin Nucl MedSep 7, 2026 (epub)
Case ReportPediatricsOncology (Medical)Nuclear Medicine

Mingyu Zhang, Jie Feng, Keyu Zhang et al.

✦ AI-curated · Sources linked

Case in brief

A 6-year-old boy with high-risk neuroblastoma underwent multimodal therapy and follow-up 18F-MFBG PET/CT for treatment response assessment. Imaging showed multiple skeletal metastases with markedly increased tracer accumulation: SUVmax was 77.1, exceeding the concurrent physiological bladder activity. The report highlights this unusual uptake pattern in osseous metastatic disease.

What made this case unusual

The skeletal metastases accumulated 18F-MFBG more intensely than the physiological urinary bladder, contrary to the typically lower uptake described for neuroblastoma metastases.

Diagnostic / clinical pearl

On 18F-MFBG PET/CT, neuroblastoma bone metastases can show uptake that exceeds concurrent bladder activity; intense skeletal uptake should not be dismissed as incompatible with metastatic disease.

Source

PubMed · PMID 42725439

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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