Triggering modalities to synchronise non-invasive respiratory support in preterm infants: a systematic review and meta-analysis.
Fabio A Blom, Ruud W van Leuteren, Frans H de Jongh et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of synchronised nasal intermittent positive pressure ventilation (sNIPPV) in preterm infants, comparing it to other non-invasive respiratory support modes. The analysis included 49 studies with 2864 infants, revealing a significant reduction in extubation failure (risk ratio=0.38; 95% CI 0.17 to 0.85; p=0.03) when using sNIPPV compared to nasal continuous positive airway pressure (nCPAP).
Key findings
- sNIPPV significantly reduced extubation failure compared to nCPAP (risk ratio=0.38; 95% CI 0.17 to 0.85; p=0.03).
- Physiological outcomes, particularly breathing effort, improved during sNIPPV compared to nCPAP and NIPPV.
- Non-invasive neurally adjusted ventilatory assist showed a synchronisation rate of 80%-99% and reduced patient-ventilator asynchrony.
Why it matters
Understanding the effectiveness of different non-invasive respiratory support modalities is crucial for improving clinical outcomes in preterm infants. This review highlights the potential benefits of sNIPPV, which may lead to better management strategies in neonatal care.