Immune-checkpoint inhibitor-induced bullous pemphigoid in patients with metastatic renal cell carcinoma: two case reports and systematic review of the literature.

Acta OncolSep 9, 2026 (epub)

Panagiotis Filis, Magnus Lindskog, Philip Curman et al.

✦ AI-curated · Sources linked

Case in brief

Two patients with metastatic renal cell carcinoma developed bullous pemphigoid after treatment with immune-checkpoint inhibitors. Both presented with tense bullae and vesiculobullous eruptions, confirmed by skin biopsy and immunological testing. Following immunosuppressive treatment, both patients showed improvement, highlighting the need for careful monitoring of skin reactions in patients receiving ICIs.

Diagnostic / clinical pearl

Clinicians should be vigilant for bullous pemphigoid in patients receiving immune-checkpoint inhibitors, especially after prolonged treatment, as early recognition can facilitate timely management.

Source

Published in Acta Oncol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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