Holmium laser enucleation of the prostate for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia.
Niranjan Sathianathen, Eu Chang Hwang, Sarah Jane Brown et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of holmium laser enucleation of the prostate (HoLEP) compared to other surgical treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH). The analysis included 52 randomized trials with 6242 participants. HoLEP showed little to no difference in short-term urologic symptom scores compared to transurethral resection of the prostate (TURP) with a mean difference of -0.67.
Key findings
- HoLEP may result in little to no difference in short-term urologic symptom scores (MD -0.67).
- HoLEP may result in little to no difference in short-term quality of life (MD -0.04).
- HoLEP likely reduces the need for blood transfusion (RR 0.19).
- HoLEP likely results in little to no difference in re-treatment (RR 0.45).
Why it matters
Understanding the comparative effectiveness of HoLEP versus other surgical options for BPH is crucial for clinicians to make informed decisions about patient management and treatment selection, particularly regarding symptom relief and safety outcomes.