The effects of cyanoacrylate and concentrated growth factor on wound healing and patient comfort at the palatal donor site: a randomized controlled clinical trial.
Clin Oral InvestigSep 7, 2026 (epub)
Dicle Altindal, Elif Töre Sari Can, Nazli Zeynep Alpaslan
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In 30 seconds
This randomized controlled trial assessed the effects of cyanoacrylate and concentrated growth factor (CGF) on postoperative outcomes at palatal donor sites in 60 patients undergoing free gingival grafts. The CGF group reported significantly lower pain scores in the first hour and improved epithelialization rates by day seven compared to the control group, with a p-value of <0.001 for epithelialization outcomes.
Key findings
- CGF group had lower VAS pain scores compared to control in the first hour (p=0.040).
- 80% of control patients had no epithelialization on day seven vs 10% in CGF (p<0.001).
- NA consumed was lower in the CGF group compared to control in the first three days (p<0.05).
- HI score was lower in the control group than CGF and cyanoacrylate groups on day seven (p=0.020).
Why it matters
Understanding the impact of CGF and cyanoacrylate on wound healing can inform clinical practices for managing donor site morbidity, potentially improving patient comfort and recovery outcomes following gingival graft procedures.