Factors associated with periprosthetic joint infection following total knee arthroplasty: an updated systematic review and meta-analysis.
Arch Orthop Trauma SurgSep 4, 2026 (epub)
Haoyue Gao, Yajie Deng, Yuling Ma et al.
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In 30 seconds
This systematic review and meta-analysis evaluated factors associated with periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) across 25 observational studies. Key findings indicated that a BMI ≥30 kg/m² was associated with a significantly higher odds ratio of 5.72 (95% CI 2.65-12.36) for PJI, among other factors.
Key findings
- Male sex was associated with PJI (OR = 1.39, 95% CI 1.27-1.51).
- Type 2 diabetes mellitus increased the odds of PJI (OR = 2.09, 95% CI 1.45-3.01).
- A BMI ≥30 kg/m² had an odds ratio of 5.72 (95% CI 2.65-12.36) for PJI.
- Postoperative urinary tract infection was linked to PJI (OR = 3.59, 95% CI 1.15-11.21).
Why it matters
Understanding the factors associated with PJI can aid clinicians in identifying at-risk patients and implementing preventive strategies during the perioperative period, potentially reducing infection rates and improving surgical outcomes.