Angiosarcoma Presenting as a Chronic Non-Healing Lower Extremity Ulcer in Lymphoedema: A Challenge.
Int Wound JSep 1, 2026
Megan Koch, Leena Hani, Erica Friedman et al.
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Case in brief
A 74-year-old woman with chronic lower extremity lymphoedema presented with a non-healing ulcer, initially treated as cellulitis and venous ulceration. Due to lack of improvement, a biopsy was performed, revealing angiosarcoma. The patient underwent surgical resection followed by adjuvant radiotherapy, remaining disease-free for over 4 years before experiencing recurrence and subsequent death.
Diagnostic / clinical pearl
In patients with chronic non-healing ulcers, particularly those with longstanding lymphoedema, malignancy such as angiosarcoma should be considered, and early biopsy is crucial for timely diagnosis.