Rechallenge With 177 Lu-PSMA Radioligand Therapy in Metastatic Castration-resistant and Hormone-sensitive Prostate Cancer : Lessons From a Multicase Experience.

Clin Nucl MedJul 13, 2026 (epub)
Case ReportOncology (Medical)

Faeze Rabani, Nikoo Rezaei, Amin Tanha Saber et al.

✦ AI-curated · Sources linked

Case in brief

Four patients with metastatic hormone-sensitive and castration-resistant prostate cancer were treated with 177 Lu-PSMA-617 radioligand therapy. Initial treatment resulted in significant declines in PSA levels, pain relief, and positive radiographic responses. Following disease progression, rechallenge with additional cycles of 177 Lu-PSMA led to renewed PSA reductions and sustained symptomatic improvement, with no severe toxicities observed.

Diagnostic / clinical pearl

Rechallenge with 177 Lu-PSMA-617 radioligand therapy can be effective in patients with metastatic prostate cancer who have previously progressed after initial treatment.

Why it matters

This case highlights the potential for effective retreatment strategies in advanced prostate cancer, suggesting that prior exposure to radioligand therapy does not eliminate the possibility of future benefits.

Source

PubMed · PMID 42544985

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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