The Effect of Melatonin on Sleep Quality, Anxiety, and Depression in Patients with Primary Breast Cancer Undergoing Adjuvant Chemotherapy Type: A Randomized, Double-Blind, Placebo-Controlled Trial.

Cancer InvestJul 30, 2026 (epub)

Mohsen SeddighShamsi, Mohsen Esfandbod, Shabnam Jalali et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized, double-blind, placebo-controlled trial evaluated the effects of melatonin on sleep quality, anxiety, and depression in 40 patients with primary breast cancer undergoing adjuvant chemotherapy. Melatonin significantly improved sleep latency, sleep efficiency, and total Pittsburgh Sleep Quality Index scores compared to placebo, with notable effects during the Taxol phase of chemotherapy.

Key findings

Melatonin improved sleep latency from 1.50 to 1.00 (P=0.001) compared to placebo.
Sleep efficiency increased from 1.11 to 0.56 (P=0.003) with melatonin treatment.
Total PSQI scores decreased from 8.39 to 6.50 (P=0.003) in the melatonin group.
Anxiety levels improved from 7.33 to 5.67 (P=0.077) during the Taxol phase.

Why it matters

Improving sleep quality and reducing anxiety in breast cancer patients undergoing chemotherapy can enhance their overall well-being and treatment experience. Melatonin may offer a non-invasive option to address these common issues.

Source

PubMed · PMID 42533530

Published in Cancer Invest. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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