Distinct outcome patterns according to RAS and BRAF status in MSI-H/dMMR mCRC treated with immune checkpoint inhibitors: A systematic review and meta-analysis.

Cancer Treat RevJun 25, 2026 (epub)
Clinical ResearchOncology (Medical)

Andrea Pretta, Riccardo Giampieri, Andrea Bottelli et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis evaluated the impact of RAS and BRAF mutational status on outcomes in patients with MSI-H/dMMR metastatic colorectal cancer (mCRC) treated with immune checkpoint inhibitors (ICIs). Among 2564 patients from nine studies, RAS-mutated disease was linked to longer progression-free survival (PFS) (HR 0.81), while BRAF mutations were associated with shorter PFS (HR 1.37) and worse overall survival (OS) (HR 1.74).

Key findings

  • RAS-mutated disease was associated with longer PFS (HR 0.81, 95% CI 0.66-0.99).
  • BRAF-mutated tumours showed shorter PFS (HR 1.37, 95% CI 1.11-1.69).
  • Overall survival was significantly worse in BRAF-mutated disease (HR 1.74, 95% CI 1.17-2.59).
  • Response rates may increase with dual checkpoint blockade in BRAF-mutated and wild-type subgroups.

Why it matters

Understanding the distinct outcomes based on RAS and BRAF status in MSI-H/dMMR mCRC can guide clinicians in personalizing immunotherapy approaches, potentially improving patient management and outcomes.

Source

PubMed · PMID 42497817

Published in Cancer Treat Rev. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Oncology (Medical)

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.