Relationship between miRNAs dysregulation and the metastatic process associated with epithelial-mesenchymal transition in oral squamous cell carcinoma: A systematic review.

Arch Oral BiolJul 15, 2026 (epub)
Clinical ResearchOncology (Medical)

Flávia Letícia Magalhães Lemos, Lena Heloyse Dos Santos Guimarães, Nathalia Carolina Fernandes Fagundes et al.

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In 30 seconds

This systematic review evaluated the link between miRNA dysregulation and the metastatic process related to epithelial-mesenchymal transition (EMT) in oral squamous cell carcinoma (OSCC). Eighteen studies were analyzed, revealing that eight deregulated miRNAs were significantly associated with lymph node metastasis, while four correlated with distant metastasis. The findings suggest potential diagnostic and therapeutic targets in OSCC management.

Key findings

  • Seventeen miRNAs involved in EMT regulation were identified, with five upregulated and twelve downregulated in OSCC tissues.
  • Eight deregulated miRNAs showed a significant association with lymph node metastasis.
  • Four miRNAs demonstrated a significant correlation with distant metastasis.

Why it matters

Understanding the role of miRNAs in the metastatic process of OSCC can enhance diagnostic accuracy and inform therapeutic strategies, potentially improving patient outcomes in clinical practice.

Source

PubMed · PMID 42480174

Published in Arch Oral Biol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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