Systematic review of antiemetic therapy for low emetogenic chemotherapy: comparing 5-HT 3 receptor antagonists and dexamethasone.

Int J Clin OncolJul 21, 2026 (epub)
Clinical ResearchOncology (Medical)Open access

Takeshi Aoyama, Hirotoshi Iihara, Masakazu Abe et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review evaluated the comparative effectiveness of 5-HT3 receptor antagonists versus dexamethasone for preventing chemotherapy-induced nausea and vomiting in adult patients receiving low-emetogenic chemotherapy. The review found no direct comparative evidence from randomized controlled trials or observational studies, highlighting a significant gap in the literature.

Key findings

  • No direct comparative evidence was found between 5-HT3 receptor antagonists and dexamethasone for low-emetogenic chemotherapy.
  • The review screened 430 articles, ultimately including no studies that met the inclusion criteria.
  • Future research should focus on prospective comparative trials and real-world data analyses.

Why it matters

Understanding the effectiveness of antiemetic therapies is crucial for improving patient quality of life during chemotherapy. This review underscores the need for robust evidence to guide clinical practice in managing chemotherapy-induced nausea and vomiting.

Source

PubMed · PMID 42479257Free full text on PubMed Central

Published in Int J Clin Oncol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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