Efficacy of doxorubicin-loaded graphene nanoplatform chemo-photothermal therapy versus photothermal therapy alone for breast cancer xenograft tumors: a meta-analysis.
Hua-Wei Gao, Zhi-Hong Li, Yan Lu et al.
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In 30 seconds
This meta-analysis evaluated the efficacy of doxorubicin-loaded graphene nanoplatform chemo-photothermal therapy (CPT) versus photothermal therapy (PTT) alone in breast cancer xenograft models. The analysis included nine studies with 46 animals in each group, revealing a pooled standardized mean difference (SMD) of -2.20 (95% CI: -2.76 to -1.65, p < 0.0001), indicating significantly greater tumor volume suppression with CPT.
Key findings
- The pooled SMD for tumor volume suppression was -2.20 (95% CI: -2.76 to -1.65, p < 0.0001).
- No significant differences were found in subgroup analyses by cell line, graphene type, or publication period.
- Sensitivity analyses yielded pooled SMDs ranging from -2.09 to -2.37.
- Secondary endpoints showed limited reporting on survival, toxicity, and biodistribution.
Why it matters
The findings suggest that doxorubicin-loaded graphene nanoplatform CPT may offer enhanced tumor suppression compared to PTT alone, indicating potential for improved therapeutic strategies in breast cancer treatment. However, further studies are needed to assess long-term safety and efficacy.