Association between packed red blood cell transfusion and clinical deterioration in neonatal necrotizing enterocolitis: a systematic review and meta-analysis.

Ann MedMay 24, 2026 (epub)
Clinical ResearchPediatricsGastroenterologyOpen access

Jinglan Huang, Qian Gao, Ziqing Xu et al.

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In 30 seconds

This systematic review and meta-analysis examined the relationship between packed red blood cell (pRBC) transfusion and clinical deterioration in neonates with necrotizing enterocolitis (NEC). Analyzing five studies with 971 neonates, the results indicated a significant association, with an odds ratio of 6.05 (95% CI: 3.02-12.14) for clinical worsening following pRBC transfusion.

Key findings

  • The pooled analysis showed an odds ratio of 6.05 for clinical deterioration associated with pRBC transfusion.
  • Five studies involving 971 neonates with NEC were included in the analysis.
  • The findings suggest a potential link between pRBC transfusion and exacerbation of NEC.

Why it matters

Understanding the potential risks associated with pRBC transfusion in neonates with NEC is crucial for clinicians, as it may influence transfusion practices and patient management strategies in this vulnerable population.

What to keep in mind

The analysis was limited by the small number of eligible studies included, which affects the robustness of the findings.

Source

PubMed · PMID 42177762Free full text on PubMed Central

Published in Ann Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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