Endoscopic Ultrasound-Guided Franseen Fine-Needle Biopsy for Solid Pancreatic Lesions: A Systematic Review and Meta-Analysis.

Dig Dis SciMay 19, 2026 (epub)
Clinical ResearchGastroenterologyOpen access

Adnan Bhat, Muhammad Arham, Zahra Ali et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis evaluated the diagnostic performance of the Franseen fine-needle biopsy (FNB) for solid pancreatic lesions compared to other FNB designs. Involving 16 studies with 2,010 Franseen and 2,811 comparator cases, the Franseen needle demonstrated comparable sensitivity (91.3% vs. 94.0%) and superior diagnostic accuracy (RR 1.07) compared to newer-generation needles, while reducing low-cellularity samples and specimen bloodiness.

Key findings

  • Franseen needle sensitivity was 91.3% compared to 94.0% for newer-generation needles.
  • Diagnostic accuracy was higher with the Franseen needle (RR 1.07, 95% CI 1.01-1.14).
  • Franseen needle had fewer low-cellularity samples (RR 0.56, 95% CI 0.45-0.69).
  • Overall adverse event rate was slightly higher for the Franseen needle (RR 1.29, 95% CI 1.06-1.57).

Why it matters

Accurate tissue acquisition is crucial for managing solid pancreatic lesions. The Franseen needle's improved diagnostic accuracy and reduced low-cellularity samples may enhance clinical decision-making and patient outcomes in gastroenterology.

Source

PubMed · PMID 42156629Free full text on PubMed Central

Published in Dig Dis Sci. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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