Comparative efficacy and safety of endoscopic treatments for gastric varices: a systematic review and network meta-analysis.

EndoscopyMay 19, 2026 (epub)
Clinical ResearchGastroenterology

Mattia Brigida, Stefano Francesco Crinò, Abdulrahman Alfadda et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and network meta-analysis evaluated the efficacy and safety of various endoscopic treatments for gastric varices in 760 patients across 10 randomized controlled trials. EUS-guided cyanoacrylate injection and EUS-guided coil+cyanoacrylate injection demonstrated significantly lower rebleeding rates compared to direct endoscopic cyanoacrylate injection, with risk ratios of 0.39 and 0.15, respectively.

Key findings

  • EUS-guided cyanoacrylate injection reduced rebleeding rates (RR 0.39, 95%CI 0.27-0.58) compared to direct endoscopic cyanoacrylate injection.
  • EUS-guided coil+cyanoacrylate injection showed even lower rebleeding rates (RR 0.15, 95%CI 0.03-0.90).
  • EUS-guided cyanoacrylate injection had a lower adverse event rate (RR 0.59, 95%CI 0.48-0.72) than endoscopic cyanoacrylate injection.
  • Large-volume band ligation and thrombin injection also had lower adverse event rates compared to endoscopic cyanoacrylate injection.

Why it matters

Understanding the comparative efficacy and safety of endoscopic treatments for gastric varices is crucial for optimizing patient management and reducing complications associated with rebleeding.

What to keep in mind

The quality of evidence was very low, indicating a need for further randomized controlled trials to confirm findings.

Source

PubMed · PMID 42155472

Published in Endoscopy. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Gastroenterology

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.