Incidence of Bacille Calmette-Guérin associated lymphadenitis in healthy children: A systematic review and meta-analysis.

Hum Vaccin ImmunotherMay 4, 2026 (epub)
Clinical ResearchPediatricsOpen access

BongKyoo Choi, Hyunjeong Cho, Ju-Yeun Lee et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis evaluated the incidence of Bacille Calmette-Guérin (BCG) lymphadenitis in healthy children, analyzing data from 52 studies involving approximately 1.8 million children. The pooled incidence proportion was found to be 2.5% (95% CI, 1.6-3.6). The study revealed significant variability in incidence based on surveillance methods and study design.

Key findings

  • The pooled incidence proportion of BCG lymphadenitis was 2.5% (95% CI, 1.6-3.6).
  • Active surveillance reported a significantly higher incidence proportion compared to passive surveillance.
  • Randomized controlled trials showed a higher incidence than prospective and retrospective cohort studies.
  • Incidence varied significantly based on study quality, publication period, and BCG strain.

Why it matters

Understanding the incidence of BCG lymphadenitis is crucial for clinicians to assess the risk associated with BCG vaccination in children. Variability in reported outcomes can inform vaccination strategies and patient counseling.

Source

PubMed · PMID 42081288Free full text on PubMed Central

Published in Hum Vaccin Immunother. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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