Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review.

Drug DelivMay 1, 2026 (epub)
Clinical ResearchPediatricsOncology (Medical)Open access

Amirhossein Masroor, Nienke Streefkerk, Martine Van Grotel et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review evaluated the efficacy and safety of locally applied otoprotective agents other than sodium thiosulfate (STS) to prevent cisplatin-induced hearing loss in pediatric cancer patients. The review included 70 preclinical and eight clinical studies, identifying dexamethasone and N-acetylcysteine as the most investigated agents. Dexamethasone showed statistically significant but not clinically relevant benefits in two of three randomized clinical trials.

Key findings

  • Dexamethasone showed statistically significant benefits in two out of three randomized clinical trials.
  • N-acetylcysteine was minimally effective in one randomized clinical trial and one clinical study.
  • The review included 70 preclinical studies and eight clinical studies on otoprotective agents.

Why it matters

Cisplatin-induced hearing loss significantly affects the quality of life in pediatric cancer patients. Understanding alternative otoprotective strategies is crucial for improving patient outcomes and managing treatment-related side effects.

Source

PubMed · PMID 42068011Free full text on PubMed Central

Published in Drug Deliv. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Pediatrics

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.