Consolidative Camrelizumab Following Definitive Concurrent Chemoradiation Therapy With Involved-Field Irradiation in Locally Advanced Esophageal Squamous Cell Carcinoma: A Single-Arm Phase 2 Trial.

Int J Radiat Oncol Biol PhysApr 22, 2026 (epub)
Clinical ResearchOncology (Medical)Gastroenterology

Yunjie Cheng, Jianing Wang, Xiaoyan Lv et al.

✦ AI-curated · Sources linked

In 30 seconds

This single-arm phase 2 trial evaluated the efficacy of camrelizumab consolidation therapy in 32 patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) following definitive concurrent chemoradiation therapy (dCCRT). The study found a disease control rate of 59.4% and 1-year progression-free survival (PFS) rate of 81.3%.

Key findings

  • The disease control rate was 59.4% (19 of 32 patients).
  • 1-year progression-free survival (PFS) rate was 81.3%.
  • 1-year overall survival (OS) rate was 96.9%.
  • Most adverse events were grade 1 or 2, with anemia occurring in 68.8% of patients.

Why it matters

The study highlights the potential role of consolidation immunotherapy in improving outcomes for patients with unresectable locally advanced ESCC, a population at high risk for recurrence after standard treatment.

Source

PubMed · PMID 42031221

Published in Int J Radiat Oncol Biol Phys. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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