Endoscopic Surveillance in Serrated Polyposis Syndrome, Two or Three-Year Intervals: A Non-inferiority Randomized Trial.

Dig Dis SciApr 21, 2026 (epub)
Clinical ResearchGastroenterologyOpen access

Jorge López-Vicente, Daniel Rodríguez-Alcalde, Luis Hernández Villalba et al.

✦ AI-curated · Sources linked

In 30 seconds

This multicenter, randomized non-inferiority trial evaluated the incidence of advanced neoplasia in patients with serrated polyposis syndrome undergoing colonoscopy surveillance at two- versus three-year intervals. Among 131 patients, the incidence of advanced neoplasia was 6.9% for the two-year group and 13.6% for the three-year group, with no statistical difference (p = 0.208).

Key findings

  • Advanced neoplasia incidence was 6.9% in the 2-year group and 13.6% in the 3-year group.
  • No colorectal cancer was detected among the resected lesions.
  • The risk difference for advanced neoplasia was +6.7%, exceeding the non-inferiority margin.
  • Diagnosis of serrated polyposis syndrome ≤3 years was associated with advanced neoplasia (OR 4.4).

Why it matters

Understanding the optimal surveillance interval for serrated polyposis syndrome is crucial for balancing cancer risk and healthcare resource utilization. This study provides insights into the safety of extending surveillance intervals.

Source

PubMed · PMID 42012787Free full text on PubMed Central

Published in Dig Dis Sci. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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