Systematic Literature Review Informing Paediatric Rheumatology European Society/Childhood Arthritis and Rheumatology Research Alliance-Endorsed Recommendations for the Treat-to-Target Strategy in Juvenile Dermatomyositis.
J RheumatolSep 1, 2026 (epub)
Clinical ResearchRheumatology
Ana Isabel Rebollo-Giménez, Talia Baird, Brian M Feldman et al.
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In 30 seconds
This systematic literature review aimed to evaluate evidence supporting the treat-to-target (T2T) strategy in managing juvenile dermatomyositis (JDM). The review included 220 articles, revealing strong or moderate evidence in 24 studies. Although no direct comparisons between conventional and targeted management were found, insights on therapeutic endpoints were identified to inform T2T strategy development.
Key findings
- A total of 2714 articles were retrieved, with 220 included in the final review.
- Strong evidence was found in 2 articles, and moderate evidence in 22 articles.
- No studies directly compared conventional management with a targeted approach.
Why it matters
Understanding the T2T strategy in JDM is crucial for clinicians as it may enhance treatment outcomes by focusing on specific therapeutic goals and optimal timing for interventions.