Pseudoxanthoma Elasticum Treated with Endoscopic Clip Hemostasis for Upper Gastrointestinal Bleeding from a Dieulafoy Lesion.

Intern MedMar 24, 2026 (epub)
Case ReportGastroenterologyMedical Genetics

Ryosuke Kaji, Akiko Ohno, Jun Miyoshi et al.

✦ AI-curated · Sources linked

Case in brief

A 30-year-old woman presented with upper gastrointestinal bleeding from a Dieulafoy lesion and underwent endoscopic hemostasis. Further history revealed pseudoxanthoma elasticum (PXE) with an ABCC6 gene mutation, for which she had not received medical care for many years. The lesion was considered associated with PXE. Follow-up esophagogastroduodenoscopy showed characteristic cirsoid aneurysms. Examination also identified characteristic skin and eye findings of PXE, without coronary or cerebrovascular abnormalities.

What made this case unusual

The Dieulafoy lesion occurred in a patient with PXE, and follow-up endoscopy revealed cirsoid aneurysms, linking the gastrointestinal presentation to characteristic vascular findings of the systemic disorder.

Diagnostic / clinical pearl

A Dieulafoy lesion presenting with upper gastrointestinal bleeding may prompt consideration of an underlying systemic disorder; in this case, further history and systemic examination identified PXE.

Source

PubMed · PMID 41882891

Published in Intern Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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