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2000 articles
November 202624
2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.
This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.
Postoperative Tumor-Informed Circulating Tumor DNA Status for Molecular Residual Disease Detection After Curative-Intent Resection of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled observational evidence on postoperative tumor-informed circulating tumor DNA (ctDNA) as a marker of molecular residual disease after curative-intent resection of…
Imaging-Based AI for Predicting Pathological Complete Response in Esophageal Cancer After Neoadjuvant Therapy: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed imaging-based AI models for predicting pathological complete response after neoadjuvant therapy for esophageal cancer, separating internal from external validation.
Primary Synovial Sarcoma of the Thyroid Gland Presenting With Early Pulmonary Metastasis: Diagnostic Pathway, SS18 Gene Fusion Confirmation, and Clinical Course.
A 47-year-old woman presented with dysphagia and a left-sided neck mass. Initial fine-needle aspiration was non-diagnostic; repeat sampling suggested a spindle cell neoplasm.
Measles-like hypermutation of a Newcastle disease virus drives fatal encephalitis during BCMA × CD3 T-cell-redirecting immunotherapy.
A patient with multiple myeloma receiving maintenance teclistamab, daratumumab, and lenalidomide developed rapidly progressive brainstem-cerebellar encephalitis.
Poly (ADP-ribose) polymerase inhibitors (PARPi) for treating advanced epithelial ovarian cancer.
This Cochrane systematic review and meta-analysis assessed randomised trials of PARP inhibitors (PARPi) in women with newly diagnosed or recurrent epithelial ovarian cancer. It included 24 studies with 8961 participants.
Combined Immunotherapy and Hybrid Dose-Fraction Radiotherapy for Driver-Negative Metastatic NSCLC: A Phase II Trial with Parallel Preclinical Studies.
This single-arm, multicenter phase II trial evaluated hybrid dose-fraction radiotherapy added during first-line chemoimmunotherapy maintenance in 83 patients with stage IV driver-negative metastatic NSCLC.
Spatial transcriptomics tumor microenvironment determinants of tyrosine kinase inhibitor response in renal cell carcinoma: results from a phase 2 clinical trial.
This phase 2 clinical trial examined whether spatially resolved tumor gene-expression patterns were associated with sunitinib response in 46 patients with metastatic clear cell renal cell carcinoma.
The effect of listening to Qur'an on quality of life and sleep quality in breast cancer patients undergoing chemotherapy: a randomized controlled trial.
This open-label, participant-level randomized controlled trial with blinded statistical analysis examined whether listening to Qur’an during chemotherapy affected patient-reported quality of life and sleep in women with…
Impact of nasogastric administration using the simple suspension method on serum tirabrutinib levels: A case report.
An 82-year-old man with relapsed primary central nervous system lymphoma began tirabrutinib at 320 mg/day while fasting. As dysphagia progressed, administration changed from swallowing tablets to nasogastric delivery by…
Diagnostic yield and early outcomes of radical prostatectomy without prior histopathologic diagnosis: a single-arm systematic review and meta-analysis.
This single-arm systematic review and random-effects meta-analysis assessed radical prostatectomy without prior histopathologic confirmation in adult men with high clinical suspicion of clinically significant prostate…
Dirozalkib versus Crizotinib in Advanced Anaplastic Lymphoma Kinase Inhibitor-Naïve ALK -Positive Non-Small-Cell Lung Cancer: A Multicenter, Randomized Phase III Trial.
DIAMOND-2 was a multicenter, randomized, open-label phase III trial comparing dirozalkib with crizotinib in adults with ALK inhibitor-naïve, ALK-positive advanced non-small-cell lung cancer.
Physiological prehabilitation for patients undergoing cellular therapy in multiple myeloma and lymphoma: a systematic review.
This systematic review examined exercise-based physiological prehabilitation in adults with multiple myeloma or lymphoma before cellular or immune-based therapy.
Sequencing trastuzumab deruxtecan and sacituzumab govitecan in metastatic breast cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether treatment order affects outcomes when patients with metastatic breast cancer receive both trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG).
Pertuzumab in HER2-positive breast cancer: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis pooled 8 randomized controlled trials involving 8367 patients with HER2-positive breast cancer to assess pertuzumab-based regimens.
Association of HTR3A and COMT polymorphisms with electroacupuncture response for chemotherapy-induced nausea and vomiting in breast cancer: a secondary analysis of a randomized controlled trial.
This exploratory, treatment-stratified secondary analysis of a randomized controlled trial examined whether three HTR3A and COMT polymorphisms were associated with complete protection (CP) against chemotherapy-induced…
Dose-dense neoadjuvant bi-weekly nab-paclitaxel followed by epirubicin-cyclophosphamide versus bi-weekly docetaxel followed by epirubicin-cyclophosphamide in patients with HR+/HER2- early breast cancer: a multicentre, randomised, phase III trial.
This multicentre, randomised phase III trial at three hospitals in China compared dose-dense neoadjuvant nab-paclitaxel with docetaxel, each followed by epirubicin-cyclophosphamide, in patients with early HR+/HER2−…
Multiorgan [ 18 F]florbetapir PET/CT uptake in multiple myeloma-associated systemic AL amyloidosis: a case report.
A 77-year-old man with multiple myeloma underwent whole-body [18F]florbetapir PET/CT because AL amyloidosis was suspected. The scan showed prominent tracer retention in the myocardium, thyroid, lungs, parotid glands…
Efficacy and safety of the cladribine, idarubicin, and cytarabine regimen for treating acute myeloid leukemia: a systematic review and single-arm meta-analysis.
This systematic review and single-arm meta-analysis assessed the efficacy and safety of cladribine, idarubicin, and cytarabine (CIA) for acute myeloid leukemia (AML), separating newly diagnosed (ND) from…
Molecular Diagnostics and Clinicopathologic Spectrum of Kinase Fusion-Positive Spindle Cell Neoplasms of the Oral and Maxillofacial Region: A Systematic Review and Pooled Patient-Level Analysis.
This systematic review and pooled patient-level analysis characterized kinase fusion-positive spindle cell neoplasms of the oral and maxillofacial region using published reports.
Multifocal intradural extramedullary myxopapillary ependymoma of the spine.
A 34-year-old man presented with sudden severe non-radicular low-back pain but no neurological deficit. MRI showed multiple enhancing intradural extramedullary lesions from T12-L1 to S1; the dominant T12-L1 lesion…
Antibiotic Exposure and Treatment Outcomes in Head and Neck Squamous Cell Carcinoma and Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed whether systemic antibiotic exposure around treatment initiation was associated with outcomes in patients with head and neck squamous cell carcinoma or nasopharyngeal…
Prophylactic dexamethasone for prevention of opioid-induced nausea and vomiting in cancer patients: a randomised controlled trial (DEX-OINV Trial).
This open-label randomised controlled trial at a tertiary cancer centre evaluated prophylactic oral dexamethasone in opioid-naïve adults with cancer starting oral morphine.
Vitamin D status and chemotherapy-induced peripheral neuropathy in patients with cancer: a systematic review with exploratory quantitative synthesis.
This systematic review with exploratory quantitative synthesis assessed whether serum or plasma 25-hydroxyvitamin D status was associated with chemotherapy-induced peripheral neuropathy (CIPN) in patients receiving…
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