Loss of blood pressure control after rifampin initiation: a clinically significant antihypertensive drug-drug interaction.
A man in his early 60s with well-controlled hypertension experienced a sudden increase in blood pressure two weeks after starting isoniazid-rifampin therapy for latent tuberculosis.
Clinical pearl
Clinicians should consider potential drug-drug interactions, such as those caused by rifampin, when patients experience sudden changes in blood pressure control.