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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

FeaturedClinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

BMJNov 11, 2026

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

Why it matters

Perioperative hypotension and vasopressor use were less frequent when older patients omitted their ACE inhibitor or ARB on the morning of surgery.

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Also worth knowing

Clinical ResearchEndocrinology

Effects of Vitamin D Supplementation in Combination With Exercise Training on Body Composition and Muscular Strength in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.

This systematic review and dose-response meta-analysis of randomized controlled trials assessed whether vitamin D supplementation added to exercise improves body composition or muscular strength compared with exercise…

Nutr RevNov 12, 2026Read summary
Clinical ResearchOncology (Medical)

Primary Endocrine Therapy vs Upfront Surgery for Older Women With Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis compared primary endocrine therapy (pET) with upfront surgery for operable, nonmetastatic, estrogen receptor-positive breast cancer in older women.

JAMA Netw OpenNov 2, 2026Read summary
Clinical ResearchOrthopedic SurgeryOpen access

Operative versus nonoperative management of olecranon fractures in older adults: a systematic review and meta-analysis.

This systematic review and meta-analysis compared operative with nonoperative management of displaced olecranon fractures in older adults.

Arch Orthop Trauma SurgNov 9, 2026Read summary
Clinical ResearchAnesthesiology

Effects of opioid-free and opioid-sparing anesthesia on postoperative delirium: A systematic review and meta-analysis.

This systematic review and meta-analysis assessed opioid-free and opioid-sparing anesthesia for preventing postoperative delirium (POD) in adult surgical patients.

Medicine (Baltimore)Nov 6, 2026Read summary
Clinical ResearchPulmonologyOpen access

The Association Between Chronic Obstructive Pulmonary Disease and Postoperative Delirium: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined whether chronic obstructive pulmonary disease (COPD) is associated with postoperative delirium (POD) in surgical patients.

Int J Chron Obstruct Pulmon DisNov 4, 2026Read summary
Clinical ResearchGeriatrics

Effect of Exercise Interventions on Sarcopenia-Related Outcomes in Older Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed structured exercise versus nonexercise control in adults with type 2 diabetes whose mean age was at least 65 years.

Geriatr Gerontol IntNov 1, 2026Read summary
Clinical ResearchGeriatrics

Exercise and Nutritional Interventions for Muscle Strength, Physical Performance, and Body Composition Among Older Adults With Sarcopenia or Pre-Sarcopenia: A Network Meta-Analysis.

This network meta-analysis compared exercise, nutritional, and combined interventions with control strategies in older adults with sarcopenia or pre-sarcopenia.

Geriatr Gerontol IntNov 1, 2026Read summary
Clinical ResearchGeriatrics

Evaluating the accuracy of brief cognitive assessments for the early detection of cognitive impairment in adults across primary and specialty care settings: A systematic review and meta-analysis.

This systematic review and meta-analysis assessed brief, freely available cognitive tests for detecting cognitive impairment, including mild cognitive impairment and dementia, in adults aged 55 years and older in…

Alzheimers DementNov 1, 2026Read summary
Clinical ResearchGeriatrics

Impact of artificial intelligence-assisted health management on blood pressure and self-management efficacy in older adults with hypertension.

This randomized controlled trial compared AI-assisted health management with routine care in older adults with hypertension. The intervention included intelligent monitoring, early warning and proactive intervention.

Blood PressNov 9, 2026Read summary
Clinical ResearchGeriatricsOpen access

Prevalence of fall risk and fear of falling among older adults in the Middle East and North Africa: a systematic review and meta-analysis.

This systematic review and random-effects meta-analysis estimated fall risk and fear of falling among adults aged 60 years or older in the Middle East and North Africa (MENA).

J Glob HealthOct 30, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

The Effect of Exercise Training on Individuals With Osteoporotic Vertebral Fracture: A Randomized Controlled Trial.

This single-centre, open-label randomised controlled trial evaluated a 12-week supervised exercise programme in adults with osteoporotic vertebral fractures.

Physiother Res IntNov 8, 2026Read summary

Showing 12 of 25 publications that cleared our clinical screen in the last 14 days.

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