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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchOncology (Medical)

Durvalumab and tremelimumab, with or without lenvatinib, combined with transarterial chemoembolisation in participants with embolisation-eligible hepatocellular carcinoma (EMERALD-3): a global, randomised, open-label, sponsor-blinded, phase 3 study.

Lancet OncolSep 1, 2026

The EMERALD-3 study evaluated the efficacy and safety of combining STRIDE (tremelimumab and durvalumab) with or without lenvatinib and transarterial chemoembolisation (TACE) in patients with embolisation-eligible…

Why it matters

This study provides evidence that combining immunotherapy with lenvatinib and TACE may improve progression-free survival in patients with embolisation-eligible HCC, potentially influencing treatment strategies in this…

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Also worth knowing

Clinical ResearchGastroenterology

Five-year efficacy and safety of guselkumab for moderately to severely active Crohn's disease: Results from the phase 2 GALAXI 1 trial.

The phase 2 GALAXI 1 trial assessed the long-term efficacy and safety of guselkumab in patients with moderately to severely active Crohn's disease.

Inflamm Bowel DisSep 1, 2026Open accessRead summary
Clinical ResearchEndocrinology

Diabetes-specific nutritional formulas for tube feeding in patients with hyperglycemia: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the effects of diabetes-specific nutritional formulas (DSNF) in tube feeding on glycemic control in patients with hyperglycemia.

BMJ Open Diabetes Res CareSep 9, 2026Read summary
Clinical ResearchGeneral Surgery

Impact of PerioperAtive LidocAine Infusions on Enhanced Recovery After Noncardiac Surgery (IMPALA-ERAS) in an inpatient setting: rationale, design and protocol for a sequential, repeated crossover trial.

The IMPALA-ERAS trial is a single-centre, pragmatic, cluster-randomised, double-blinded, placebo-controlled study evaluating the effects of perioperative intravenous lidocaine infusions on postoperative recovery in 2290…

BMJ OpenSep 8, 2026Read summary
Clinical ResearchCardiology

Patient-reported barriers to dietary adherence in heart failure: a qualitative substudy of the Pro-HEART trial.

This qualitative substudy of the Pro-HEART randomized controlled trial examined barriers to dietary adherence in 24 participants with heart failure during a 12-week weight-loss phase.

Eur J Cardiovasc NursSep 8, 2026Read summary
Clinical ResearchCardiology

Beyond the Liver: Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) Associated 35% Higher Risk of Clinically Diagnosed Heart Failure With Preserved Ejection Fraction (HFpEF).

This systematic review and meta-analysis examined the association between metabolic dysfunction-associated steatotic liver disease (MASLD) and heart failure with preserved ejection fraction (HFpEF) in a population of…

Curr Cardiol RepSep 9, 2026Open accessRead summary
Clinical ResearchPulmonology

Comorbidities in clinical cohorts of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

This systematic review and meta-analysis examined the prevalence and impact of comorbidities in 606,398 patients with idiopathic pulmonary fibrosis (IPF).

Eur Respir RevSep 9, 2026Read summary
Clinical ResearchPsychiatry

Gastrointestinal Interoception and Relapse in Anorexia Nervosa.

This randomized controlled trial examined gastrointestinal interoception in 62 weight-restored females with anorexia nervosa (AN) compared to 57 healthy controls.

JAMA PsychiatrySep 1, 2026Open accessRead summary
Clinical ResearchOncology (Medical)

Multidisciplinary mHealth Rehabilitation for Patients With Abdominal Cancer Who Are Receiving Chemoradiotherapy: Randomized Phase II Trial.

This randomized phase II trial evaluated a multidisciplinary mHealth rehabilitation program for 111 patients with abdominal cancer undergoing concurrent chemoradiotherapy (CCRT).

J Med Internet ResSep 8, 2026Read summary
Clinical ResearchGastroenterology

Proton pump inhibitors in invasively ventilated patients with SARS-CoV-2: a substudy of the re-evaluating the inhibition of stress erosions trial.

This substudy of the REVISE trial evaluated the effects of pantoprazole in 532 mechanically ventilated patients with SARS-CoV-2.

BMJ OpenAug 31, 2026Open accessRead summary
Clinical ResearchGastroenterology

HBsAg decline and clearance with peg-IFN therapy added to nucleos(t)ide analogues: an individual participant data meta-analysis of prospective trials (PROSPER).

This meta-analysis evaluated the impact of peg-interferon (peg-IFN) therapy added to nucleos(t)ide analogue (NA) treatment in chronic hepatitis B patients.

GutSep 7, 2026Read summary
Clinical ResearchGastroenterology

The Role of Artificial Intelligence Combined With Digital Cholangioscopy for Indeterminant and Malignant Biliary Strictures: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis evaluated the diagnostic performance of artificial intelligence (AI) combined with digital cholangioscopy for indeterminant and malignant biliary strictures.

J Clin GastroenterolSep 6, 2026Read summary

Showing 12 of 62 publications that cleared our clinical screen in the last 14 days.

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