Trending archive
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542 articles
September 202624
A randomised, double-blind, placebo-controlled phase I clinical trial to evaluate the safety, tolerability and immunogenicity of three doses of an adjuvanted group B Streptococcus vaccine in older adults aged 55 to 75.
This phase I randomized controlled trial assessed the safety, tolerability, and immunogenicity of an adjuvanted group B Streptococcus vaccine (GBS-AlpN) in 90 older adults aged 55 to 75, including those with obesity…
Effect of manual diaphragmatic release technique on exercise capacity and sleep quality in older adults with Type II diabetes: A randomized controlled trial.
This single-blind randomized controlled trial assessed a six-week manual diaphragmatic release (MDR) program in 44 older adults with type 2 diabetes.
Long-term SBP time in target and risk of cardiovascular events in older adults: a secondary analysis of the ASPREE cohort.
This observational study analyzed data from the ASPREE cohort of 16,730 older adults (mean age 74) to assess the relationship between systolic blood pressure (SBP) time in target range (TTR) and cardiovascular events.
Deterministic and stochastic interventions in reducing drug-drug interactions in inappropriate prescribing: A systematic review.
This systematic review evaluated interventions aimed at reducing drug-drug interactions (DDIs) in inappropriate prescribing, focusing on deterministic and stochastic models.
Analysis of postural control through nonlinear methods in older adults: a randomized controlled trial.
This randomized controlled trial investigated the impact of a six-month sensorimotor training program on postural control in 86 older adults aged 55-80.
Prediction models for sarcopenia risk in type 2 diabetes mellitus: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed multivariable models predicting sarcopenia or low muscle mass in adults with type 2 diabetes.
Approach to the patient: cases of hormonal management in older transgender and gender diverse adults.
This article presents a case-based approach to managing older transgender and gender diverse (TGD) adults undergoing gender-affirming hormone therapy.
Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in elderly patients undergoing non-cardiac and non-neurosurgical procedures: protocol for a multicentre, double-blind, randomized, controlled trial.
This multicentre, double-blind, randomized controlled trial investigates whether ephedrine is more effective than phenylephrine in reducing postoperative delirium in 1,084 elderly patients undergoing major non-cardiac…
Prediction Models for In-Hospital Delirium Using Routinely Collected Electronic Health Record Data: Systematic Review.
This systematic review evaluated prediction models for in-hospital delirium using electronic health record data, analyzing 29 studies.
Effect of blood flow restricted walking on cardiovascular fitness, muscular development, and functional performance in adults: A systematic review with meta-analysis.
This systematic review and meta-analysis assessed blood flow restriction (BFR) walking versus walking without BFR in adults.
Comparative efficacy of exercise and nutritional interventions on serum IGF-1 levels in older adults with frailty and/or sarcopenia: A systematic review and network meta-analysis.
This systematic review and frequentist random-effects network meta-analysis compared exercise, nutritional supplementation, and combined interventions for serum IGF-1 in older adults with sarcopenia and/or frailty.
Controlling respiratory infections in long-term care facilities: A systematic review.
This systematic review synthesized experimental and quasi-experimental studies of non-pharmacological strategies to prevent or control respiratory infections in long-term care facilities.
Men's experiences of multiple long-term conditions and/or disability in the UK Game of Stones weight management trial: a mixed-methods evaluation.
This mixed-methods evaluation within the Game of Stones randomized controlled trial examined the experiences and health outcomes of 585 men with obesity, focusing on those with multiple long-term conditions (MLTCs)…
Effects of 12 weeks of resistance and concurrent training with graded protein intakes on lipid profile, kidney and liver biomarkers in middle-aged to older women.
This randomized controlled trial investigated the effects of varying protein intakes during resistance training (RT) and concurrent training (CT) on lipid profiles and biomarkers in 108 middle-aged to older women.
Pharmacological therapies for the prevention of fractures in men.
This systematic review and meta-analysis evaluated the effectiveness of pharmacological therapies for fracture prevention in men aged 50 and older, focusing on bisphosphonates, PTH analogues, denosumab, and romosozumab.
Alaska pollock protein intake combined with low-intensity resistance training: Effects on neuromuscular and cardiovascular adaptations in older adults.
This double-blind randomized trial examined whether Alaska pollock protein (APP) altered adaptations to low-intensity resistance training in 22 community-dwelling older adults.
Effects of an algorithmically enhanced personalized music-based intervention in patients with dementia.
This randomized controlled trial evaluated an AI-driven, personalized music intervention in 20 people with mild dementia, including Alzheimer’s disease.
Comparative efficacy of exercise modalities on cardiometabolic health in older adults: A systematic review and network meta-analysis.
This systematic review and network meta-analysis compared exercise modalities for cardiometabolic risk factors in adults aged 60 years or older, using randomized controlled trials identified through November 30, 2025.
Resistance versus concurrent training with three assigned protein targets in middle-aged and older women: a randomized 2 × 3 factorial trial.
This randomized 2 × 3 factorial trial investigated the effects of protein targets on resistance training (RT) and concurrent training (CT) in 108 middle-aged and older women.
Perioperative esketamine-containing strategies and postoperative neurocognitive outcomes in older surgical patients: a systematic review and meta-analysis of randomized controlled trials with certainty assessment.
This systematic review and meta-analysis evaluated the impact of perioperative esketamine on postoperative delirium (POD) in older surgical patients (≥60 years).
Effects of Intranasal Dexmedetomidine on the Night Before Surgery on Postoperative Delirium in Elderly Patients Undergoing Total Knee/Hip Arthroplasty. A Parallel-Arm, Randomized Controlled, Non-Inferiority Trial.
This randomized controlled trial evaluated the effects of preoperative intranasal dexmedetomidine on postoperative delirium in 316 elderly patients undergoing total knee or hip arthroplasty.
Effects of ketogenic diet on cognitive impairment in older adults: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of ketogenic diet (KD) on cognitive impairment in older adults, analyzing 12 randomized controlled trials with 707 participants.
Clinical efficacy of non-pharmacological interventions on cognitive improvement in patients with mild to moderate Alzheimer's disease: A systematic review and Bayesian network meta-analysis.
This systematic review and Bayesian network meta-analysis compared non-pharmacological interventions for cognitive outcomes in people with mild-to-moderate Alzheimer’s disease.
Frailty and mortality in patients with cancer: A systematic review and meta-analysis of 191 observational studies.
This systematic review and meta-analysis examined observational evidence on frailty and mortality among adults with cancer.
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