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937 articles
October 20265
The Acceptability and Experiences of Participating in a Preoperative Intentional Weight-Loss Programme From Diagnosis to Surgery for Colorectal Cancer.
This qualitative study, embedded in the CARE randomised controlled trial, explored how patients with colorectal cancer experienced an intensive, dietitian-supported weight-loss programme between diagnosis and surgery.
Effect of a Computer-Aided Device on Endoscopists' Biopsy Practice for Gastric Neoplasms: A Secondary Analysis of a Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial compared AI-assisted with standard gastric screening, examining biopsy practice for documented lesions.
Preoperative High-Dose Corticosteroids in Digestive Cancer Surgery: A Randomized Clinical Trial.
This multicenter, double-blind, placebo-controlled superiority randomized trial assessed whether preoperative high-dose corticosteroids improve outcomes after elective, curative-intent surgery for digestive cancer.
Systematic Review: Inclusion of Patients With Difficult-to-Treat Inflammatory Bowel Disease in Randomized Controlled Trials of Advanced Therapies.
This systematic review examined how patients with difficult-to-treat inflammatory bowel disease (DTT-IBD) were represented in randomized controlled trials of advanced therapies for ulcerative colitis and Crohn’s…
Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat-Dose Administration for up to 14 Days.
This open, randomised, parallel-group Phase 1 trial assessed intragastric pH and pharmacokinetics after single and repeated linaprazan glurate (LG) dosing in 73 healthy subjects.
September 202619
Endoscopic Ultrasound-Guided Hepaticogastrostomy With Plastic Stent Versus Metallic Stent for Malignant Biliary Obstruction: A Meta-Analysis.
This meta-analysis evaluated the efficacy and safety of plastic versus metal stents in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) for malignant biliary obstruction.
Imaging biomarkers for cardiometabolic risk stratification in metabolic dysfunction-associated steatotic liver disease: incremental value of coronary artery calcification, epicardial adipose tissue, controlled attenuation parameter, and liver stiffness measurement beyond clinical scores.
This systematic review analyzed 16 observational studies involving 34,713 adults with metabolic dysfunction-associated steatotic liver disease (MASLD) to evaluate the association between MASLD and imaging biomarkers of…
When seizure control comes at a cost: valproic acid-induced necrotising pancreatitis in a patient receiving antiepileptic polypharmacy.
A man in his late 20s with psychiatric and metabolic comorbidities developed acute necrotising pancreatitis while on antiepileptic polypharmacy, including valproic acid.
Intentional nail ingestion with caecal impaction: colonoscopic removal using a cap-assisted technique.
A woman with a history of recurrent nail ingestion presented with abdominal pain after swallowing multiple nails. Initial conservative management showed progressive migration of the nails, which clustered near the…
Acute variceal bleeding in a patient with phaeochromocytoma: the critical choice of vasoactive therapy.
A woman in her late 70s with a known left-sided phaeochromocytoma experienced acute variceal bleeding, likely due to cirrhosis. Due to the risk of hypertensive crisis, terlipressin was not used.
Lipomatous pseudohypertrophy of pancreas with chronic calcific pancreatitis presenting with nutritional dermatosis and type 3c diabetes.
A woman in her early 50s presented with erythema, scaling of the limbs, weight loss, anasarca, and chronic foul-smelling diarrhea, indicative of nutritional dermatosis due to malabsorption.
Masked polycythaemia vera presenting with extensive splanchnic venous thrombosis and mesenteric ischaemia.
A woman in her 60s with masked polycythaemia vera (PV) presented with extensive splanchnic venous thrombosis and mesenteric ischaemia after 5 years of management with phlebotomy and aspirin.
Implementing a medical opinion leader-led management model to promote timely treatment initiation among screen-positive patients with upper gastrointestinal cancer in rural China: a cluster randomised controlled trial protocol.
This cluster randomised controlled trial aims to assess the effectiveness of a medical opinion leader-led management model in reducing treatment initiation time for screen-positive upper gastrointestinal cancer patients…
The oral und systemic health risks of sugar consumption: an umbrella review.
This umbrella review analyzed systematic reviews to assess the health risks associated with free sugar consumption, focusing on both oral and systemic health.
16S rRNA Datasets of Gut Microbiota in Stent-Based Diverting Technique and Ileostomy from A Prospective, Open-Label, Multicenter Randomized Controlled Trial.
This study presents a 16S rRNA amplicon dataset from a multicenter randomized controlled trial involving 80 patients undergoing either a stent-based diverting technique (SDT) or ileostomy after rectal cancer surgery.
Efficacy and safety of tegoprazan-amoxicillin dual therapy versus bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy and safety of 14-day tegoprazan-amoxicillin dual therapy versus bismuth-containing quadruple therapy (BQT) for first-line Helicobacter pylori eradication…
A meta-analysis of transjugular intrahepatic portosystemic shunt with or without embolization for esophageal and gastric variceal bleeding in decompensated liver cirrhosis.
This meta-analysis evaluated the efficacy of transjugular intrahepatic portosystemic shunt (TIPS) with or without embolization in 3079 patients with decompensated liver cirrhosis experiencing esophageal and gastric…
Percutaneous catheter drainage versus needle aspiration for liver abscess: a systematic review and meta-analysis of efficacy and safety.
This systematic review and meta-analysis evaluated the efficacy and safety of percutaneous catheter drainage (PCD) versus needle aspiration (PNA) for liver abscesses in 1425 adults.
Efficacy of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of pancreatic enzyme replacement therapy (PERT) in improving nutrient absorption in patients with exocrine pancreatic insufficiency (EPI).
8 weeks versus 12 weeks of sofosbuvir-velpatasvir for treatment-naive, non-cirrhotic, chronic hepatitis C (RESOLVE): a multicentre, open-label, non-inferiority, randomised controlled trial in India.
The RESOLVE multicentre, open-label, randomised non-inferiority trial compared 8 versus 12 weeks of daily sofosbuvir-velpatasvir in treatment-naive adults with chronic hepatitis C without cirrhosis at five publicly…
Prognostic Models for Predicting the Severity and Mortality in People With Acute Pancreatitis - A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed how accurately four clinical scoring systems predict severe acute pancreatitis (SAP) and mortality in adults.
A Novel Pathogenic Variant in RTEL1 Causes Dyskeratosis Congenita/Hoyeraal-Hreidarsson Syndrome: A Report of Two Cases.
Two patients presented with severe immunodeficiency and very early-onset inflammatory bowel disease. Genetic testing identified the same novel homozygous RTEL1 variant, c.1670T>C (p.L557P).
Efficacy and Safety of 1-L Polyethylene Glycol With Low Ascorbic Acid for Bowel Preparation: A Randomized Clinical Trial.
This multicenter, investigator-blinded, three-arm randomized noninferiority trial compared reduced-ascorbic-acid 1-L polyethylene glycol (PEG) with standard 1-L and 2-L PEG plus ascorbic acid in low-risk adults…
Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the long-term outcomes of stem cell-based interventions for Crohn's disease-related perianal fistulas in 750 patients.
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