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2000 articles
October 202624
Survival Outcomes in Metastatic Colorectal Cancer Patients with BRAF Mutations Undergoing Targeted Chemotherapy: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Controlled Trials.
This reconstructed individual patient-data meta-analysis of 18 randomized controlled trials examined survival outcomes across targeted treatment classes in BRAF V600E-mutant metastatic colorectal cancer.
Decitabine plus busulfan-cyclophosphamide versus busulfan-cyclophosphamide myeloablative conditioning before allogeneic haematopoietic stem cell transplantation for reducing risk of relapse in adult KMT2A‑rearranged leukaemia in China: an open-label, multicentre, randomised phase 3 trial.
This open-label, multicentre, randomised phase 3 trial compared decitabine plus busulfan-cyclophosphamide (DAC-BuCy) with BuCy conditioning before allogeneic HSCT in 130 patients aged 14–65 years with KMT2A-rearranged…
Auricular point acupressure for chemotherapy-induced peripheral neuropathy: a randomized controlled trial.
This pragmatic randomized controlled trial evaluated auricular point acupressure (APA) for chemotherapy-induced peripheral neuropathy in 227 cancer survivors, comparing in-person delivery, video-guided self-placement…
Virtual Social Interaction and Psychological Capital in Chemotherapy Patients: A Randomized Controlled Trial.
This single-blind randomized controlled trial evaluated a six-week virtual social interaction program for 76 patients receiving chemotherapy at one Iranian hospital.
Infantile posterior fossa atypical teratoid/rhabdoid tumor: navigating diagnostic complexity and molecular paradigms.
A female infant younger than 1 year presented with a massive cystic-solid posterior fossa tumor and rapidly developing obstructive hydrocephalus.
Tagraxofusp, azacitidine, and venetoclax for blastic plasmacytoid dendritic cell neoplasm.
This phase 2 clinical trial evaluated tagraxofusp, azacitidine, and venetoclax in 27 patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN): 16 previously untreated and 11 with relapsed or refractory…
A 61-Year-Old Woman With Locally Advanced Pancreatic Adenocarcinoma Managed With Neoadjuvant FOLFIRINOX, Total Pancreatectomy, Splenectomy, Portal Vein and Common Hepatic Artery Resection, and Combined Vascular Reconstruction Using Splenic Artery Transposition: A Case Report.
A 61-year-old woman presented with progressive jaundice and CA 19-9 of 210 U/mL. Biopsy confirmed pancreatic ductal adenocarcinoma, and imaging showed portal vein and common hepatic artery involvement without distant…
Cutaneous clues: Malignant acanthosis nigricans and tripe palms as first signs of recurrent endometrial carcinoma.
A 73-year-old woman, disease-free for six years after treatment of stage IB endometrial endometrioid adenocarcinoma, developed acanthosis nigricans and tripe palms.
What are the palliative and end-of-life care needs and preferences of people with cancer from culturally and linguistically diverse (CALD) backgrounds?: A systematic review.
This systematic review synthesised evidence on palliative and end-of-life care needs and preferences among people with cancer from culturally and linguistically diverse (CALD) backgrounds, and on factors affecting…
Curative-intent management of de novo metastatic nasopharyngeal carcinoma: an evidence-based consensus guideline from the International Collaborating Oncology Organisations.
This international consensus guideline addresses curative-intent management of de novo metastatic nasopharyngeal carcinoma, a population historically treated with palliative intent.
Double heterozygous pathogenic germline APC and MSH2 variants in a 16-year-old female diagnosed with colorectal cancer.
A 16-year-old female presented with multiple colonic polyps and invasive colorectal carcinoma. Genetic testing identified heterozygous pathogenic variants in both APC and MSH2, consistent with the genetic basis of…
Ectopic cushing syndrome caused by intestinal neuroendocrine tumors: a systematic review.
This systematic review characterized ectopic Cushing syndrome caused by intestinal neuroendocrine tumors using published case reports and an illustrative unpublished case. It identified 24 published cases.
AI-facilitated individualized nutritional guidance with ABC-structured prompts improves short-term dietary intake adequacy and patient-reported symptoms after gastrointestinal cancer surgery: a randomized controlled trial.
This single-center randomized controlled trial compared AI-facilitated, individualized and quantified dietary guidance plus clinician review with standard discharge advice in 90 patients after laparoscopic gastric or…
High-intensity focused ultrasound as a bridging vascular-modulating therapy for fertility-sparing management of placental site trophoblastic tumor complicated by uterine arteriovenous fistula: a case report.
A 23-year-old woman had persistently plateaued serum human chorionic gonadotropin after hysteroscopic management for suspected incomplete abortion.
HHV-6 Encephalitis Presenting With Severe SIADH and CO₂ Narcosis in Non-Transplant Smoldering Adult T-Cell Leukemia/Lymphoma.
A 55-year-old woman with smoldering adult T-cell leukemia/lymphoma (ATLL), treated with systemic corticosteroids for suspected HTLV-1-associated uveitis, was admitted with pulmonary infection.
Real-Time Electronic Patient-Reported Outcome Monitoring With Digital Triage and Care-Team Integration in Early Breast Cancer: ENABLE Randomized Controlled Trial.
The multicenter, open-label ENABLE randomized controlled trial compared weekly electronic patient-reported outcome (ePRO) screening with rule-based triage and care-team alerts against an active app-based support…
Targeted BRAF /MEK inhibition as a salvage therapy for patients with metastatic melanoma harboring a BRAF L597R mutation: two case reports and review of the literature.
Two patients with metastatic melanoma harboring the BRAF L597R mutation had rapid clinical deterioration and disease progression after dual immune checkpoint inhibition.
Obesity and perioperative outcomes of robotic-assisted surgery for endometrial cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis compared perioperative outcomes after robotic-assisted surgery for endometrial cancer in patients classified as obese or non-obese by the original studies.
Recurrent Nodular Lymphocyte Predominant Hodgkin Lymphoma with Diagnostic Evolution Over Two Decades.
A 51-year-old man had a nearly 20-year history of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), with multiple relapses and prolonged remissions.
Germline BRCA-Lynch syndrome MINAS: report of six Argentinian families and a systematic review of the literature.
This report combined six Argentinian families with a systematic review of 40 publications to describe the phenotype of BRCA-Lynch syndrome (BRCA-LS) MINAS. The analysis included 92 patients from 69 families.
SUBRETINAL LAVAGE DURING DIAGNOSTIC VITRECTOMY: AN ADJUNCTIVE TECHNIQUE FOR CELL SAMPLING IN SUSPECTED VITREORETINAL LYMPHOMA.
In patients with suspected vitreoretinal lymphoma and predominant subretinal involvement, standard vitreous sampling may have limited sensitivity.
Abscopal-like Regression of Lung Metastases After Near-infrared Photoimmunotherapy Plus Nivolumab in Laryngeal Carcinoma.
A man in his 60s with recurrent laryngeal squamous cell carcinoma, base-of-tongue involvement, and multiple pulmonary metastases had progressed after several treatments, including platinum- and pembrolizumab-containing…
Familial Glioma in a Father and Son: Integrated Genomic and Multi-compartment Proteomic Profiling.
A 60-year-old father and his 35-year-old son presented with gliomas. The father’s tumor was glioblastoma, IDH-wildtype, WHO grade 4, with an unmethylated MGMT promoter; the son’s was astrocytoma, IDH-mutant, WHO grade…
Post-transplant BRAF/MEK inhibitor maintenance sustains complete remission in BRAF V600E-mutant histiocytic sarcoma.
A patient with refractory BRAF V600E-mutant histiocytic sarcoma achieved complete remission with BRAF/MEK inhibition and then underwent allogeneic stem cell transplantation.
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