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464 articles
September 202624
Deterministic and stochastic interventions in reducing drug-drug interactions in inappropriate prescribing: A systematic review.
This systematic review evaluated interventions aimed at reducing drug-drug interactions (DDIs) in inappropriate prescribing, focusing on deterministic and stochastic models.
Efficacy and safety of zilebesiran in adults with hypertension: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy and safety of zilebesiran in 1,412 adults with mild to moderate hypertension.
Efficacy and safety of rozanolixizumab in severe fibromyalgia: a phase 2A randomised, double-blind, placebo-controlled, multicentre trial.
This phase 2A, multicentre, randomised, double-blind, placebo-controlled trial assessed rozanolixizumab in adults with severe fibromyalgia at seven sites in north west England.
Metabolic syndrome severity and the effects of intensive blood pressure lowering: Results from the STEP randomized trial.
This post hoc analysis of the randomized STEP trial examined whether baseline metabolic syndrome (MetS) severity modified the benefits and risks of intensive versus standard systolic blood pressure lowering.
Weight Reduction Heterogenicity and Mediators of GLP-1RAs and Dual Agonists for Individuals With Obesity: A Meta-Analysis.
This meta-analysis examined the weight loss effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual agonists in 40,408 participants across 32 trials.
Men's experiences of multiple long-term conditions and/or disability in the UK Game of Stones weight management trial: a mixed-methods evaluation.
This mixed-methods evaluation within the Game of Stones randomized controlled trial examined the experiences and health outcomes of 585 men with obesity, focusing on those with multiple long-term conditions (MLTCs)…
Pheochromocytoma Masquerading as Acute Coronary Syndrome Complicated by Cardiogenic Shock: A CARE-Compliant Case Report.
A 59-year-old man with a history of intermittent chest tightness presented with acute cardiogenic shock, elevated troponin levels, and reduced left ventricular ejection fraction.
Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults: A Randomized Clinical Trial.
This randomized clinical trial evaluated the impact of an integrated telehealth rehabilitation program on health-related quality of life in 1916 adults with acute hypoxemic respiratory failure requiring mechanical…
Accuracy of type 2 inflammatory biomarkers to diagnose asthma in adults and children: a meta-analysis of 30 studies with prospective validation in an adult primary care cohort.
This systematic review and meta-analysis assessed fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC) for diagnosing asthma in adults and children with suspected asthma and normal spirometry, with…
Efficacy and Safety of Celecoxib Combined With Jintiange Capsules for the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of celecoxib combined with Jintiange capsules in 120 patients with knee osteoarthritis (KOA).
Pathogenic properties of myasthenia gravis AChR autoantibodies associate with clinical response to efgartigimod.
This randomized controlled trial investigated the effects of efgartigimod on AChR autoantibody profiles in 50 patients with generalized myasthenia gravis.
Effectiveness of Obesity Management Education for Healthcare Professionals: A Rapid Review and Meta-Analysis.
This meta-analysis evaluated the effectiveness of structured obesity management education for healthcare professionals (HCPs).
Kikuchi-Fujimoto Disease Associated with Hashimoto's Thyroiditis: A Case Report.
A 37-year-old woman with a history of Hashimoto's thyroiditis presented with rapidly enlarging cervical lymphadenopathy. Laboratory tests indicated mild anemia and elevated ESR, while ultrasound revealed multiple…
Safety Profile of the Non-steroidal Anti-inflammatory Drug Celecoxib in the Short-Term Management of Acute Non-cancer Pain: A Systematic Review with Meta-analysis of Randomised Controlled Trials.
This systematic review and meta-analysis evaluated the safety of celecoxib for short-term management of acute non-cancer pain in 10,693 participants across 50 studies.
Low-carbohydrate diet score subtypes and all-cause mortality in general and chronic disease populations: a systematic review and meta-analysis of prospective cohort studies.
This systematic review and meta-analysis examined the relationship between low-carbohydrate diet (LCD) scores and all-cause mortality in general and chronic disease populations.
Opportunistic and systematic screening for atrial fibrillation in adults aged ≥ 65 years in primary care: a systematic review of randomized and cluster randomized trials.
This systematic review evaluated the effectiveness of opportunistic versus systematic atrial fibrillation (AF) screening in adults aged ≥ 65 years.
Optimization strategies for care‑giving behaviors of family caregivers for patients with enterostomy: An evidence summary.
This systematic review summarizes evidence on optimizing caregiving behaviors for family caregivers of patients with enterostomy.
Comparative effects of atorvastatin and rosuvastatin on inflammatory biomarkers: a systematic review and meta-analysis of randomized head-to-head trials.
This systematic review and meta-analysis of 35 randomized controlled trials (n=6,148) compared the effects of atorvastatin and rosuvastatin on inflammatory biomarkers.
Measuring and governing potentially low-value invasive coronary angiography in Europe: a systematic review, construct-specific meta-analysis, and policy framework.
This PRISMA 2020 systematic review and construct-specific random-effects meta-analysis examined indicators used to measure potentially low-value invasive coronary angiography in European health systems.
All-cause mortality and appropriate implantable cardioverter-defibrillator shocks with first-line catheter ablation versus antiarrhythmic drugs in ischemic ventricular tachycardia: A systematic review and Meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of randomized controlled trials compared first-line catheter ablation with antiarrhythmic drug therapy in antiarrhythmic-naïve patients with ischemic cardiomyopathy and…
Comorbidities in clinical cohorts of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the prevalence and impact of comorbidities in 606,398 patients with idiopathic pulmonary fibrosis (IPF).
Global prevalence of metabolic syndrome in adults with obstructive sleep apnea: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the global prevalence of metabolic syndrome (MetS) in adults with obstructive sleep apnea (OSA), analyzing data from 102 studies involving 34,013 adults across 28…
Plasma Cluster of Differentiation 147 and Cognitive Impairment After Acute Ischemic Stroke.
This multicenter randomized controlled trial investigated the relationship between plasma CD147 levels and poststroke cognitive impairment (PSCI) in 612 patients with acute ischemic stroke.
Global prevalence and associated factors of metabolic syndrome in patients with systemic lupus erythematosus: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed the global prevalence of metabolic syndrome (MetS) in patients with systemic lupus erythematosus (SLE).
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