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1357 articles
October 202624
Early interventions for primary care patients with stress-related mental ill health: a randomised controlled non-inferiority trial of a nurse-led collaborative care intervention versus cognitive behavioural therapy.
This randomised controlled non-inferiority trial compared nurse-led collaborative care (CC) with psychologist-guided self-help cognitive behavioural therapy (GSH-CBT) in 172 adults with mild to moderate stress-related…
Costs and health-related quality of life of non-operative and surgical treatment modalities for displaced distal radius fractures: a comprehensive overview based on the CAST study.
This cost and health-related quality-of-life analysis used data from the multicenter cluster-randomized CAST trial of adults with displaced distal radius fractures.
Betaine supplementation modulates mitochondrial and redox-related adaptations in premenopausal women with overweight: a randomized controlled trial.
This randomized controlled trial examined whether eight weeks of betaine supplementation (3 g/d) affected mitochondrial-associated and redox measures in premenopausal women with overweight or obesity.
A comparison of perioperative outcomes for da Vinci robotic-assisted, laparoscopic and open surgery in oncologic procedures: a systematic literature review and meta-analysis of evidence from China.
This systematic review and meta-analysis pooled 116 comparative studies published from 2010 to 2024 on da Vinci robot-assisted surgery (dV-RAS) versus laparoscopic/video-assisted thoracoscopic surgery (LAP/VATS) or open…
Surgeon task load, ergonomics, and clinical outcomes in laparoscopic versus robotic-assisted inguinal hernia repair: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis examined randomized controlled trials comparing robotic-assisted (RIHR) with conventional laparoscopic inguinal hernia repair (LIHR), focusing on surgeon workload, ergonomics…
Dose- and modality-specific effects of exercise on BDNF and depression in middle-aged and older adults with mild cognitive impairment: A Bayesian network meta-analysis.
This Bayesian network dose-response meta-analysis examined randomized controlled trials of exercise in adults aged 50 years or older with mild cognitive impairment (MCI), assessing peripheral brain-derived neurotrophic…
Prediction models for postpartum post-traumatic stress disorder: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed multivariable models predicting post-traumatic stress disorder within 12 months after childbirth.
Disparities in GLP-1RA and SGLT2i Uptake: a Systematic Review and an Equity-First Framework for Cardiovascular-Kidney-Metabolic Care.
This systematic review synthesised U.S. evidence on disparities in prescribing and initiation of GLP-1 receptor agonists and SGLT2 inhibitors, and proposed an equity-first framework for cardiovascular-kidney-metabolic…
Preoperative pathways in adults with multiple long-term conditions undergoing major surgery: a systematic review.
This systematic review examined preoperative interventions, pathways and protocols for adults with multiple long-term conditions (MLTCs) undergoing major surgery.
Healthcare costs and burden of myasthenia gravis for patients and society: a systematic review.
This systematic review examined healthcare and societal costs associated with myasthenia gravis (MG), including 44 studies selected from 1,374 records.
HIV care cascade of adolescents and young adults in sub-Saharan Africa: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed progress toward the UNAIDS 95-95-95 targets among adolescents and young adults living with HIV in sub-Saharan Africa. It included 37 studies from 13 countries.
Effects of remimazolam versus propofol on cerebral oxygenation in elderly patients undergoing prone spine surgery: study protocol for a randomised controlled trial.
This article describes the protocol for a prospective, single-centre randomised controlled trial comparing remimazolam with propofol-based total intravenous anaesthesia in elderly patients undergoing elective thoracic…
Manual compared to automated closed-loop oxygen control strategies in hospitalised adults: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed randomised controlled trials comparing closed-loop oxygen control (CLOC) with manual adjustment in hospitalised adults receiving noninvasive oxygen.
Co-supplementation of zinc and probiotic on oxidative stress markers and sleep quality index in irritable bowel syndrome patients: a double-blind randomized controlled trial.
This parallel, double-blind randomised controlled trial assessed zinc alone and zinc plus probiotics in 84 people with irritable bowel syndrome over 90 days, comparing both with placebo.
Fosfomycin as Oral Transition Therapy Versus Continued Intravenous β-Lactams for Complicated Urinary Tract Infections Caused by Extended-Spectrum β-Lactamase-Producing Enterobacterales: A Multicenter, Open-Label, Randomized Controlled Trial.
This multicenter, open-label randomized noninferiority trial compared oral fosfomycin transition therapy with continued intravenous carbapenem or β-lactam/β-lactamase inhibitor therapy in hospitalized adults with…
Phase 2a Randomized Placebo-Controlled Human Challenge Trial of the Respiratory Syncytial Virus L-Protein Inhibitor S-337395 for Respiratory Syncytial Virus Infection.
This phase 2a, randomized, double-blind, placebo-controlled, single-centre human challenge trial assessed oral S-337395 in healthy adults aged 18–55 years inoculated with RSV-A Memphis 37b.
Survival outcomes following total intravenous versus volatile anesthesia in esophagogastric cancer surgery: a systematic review and meta-analysis.
This systematic review and meta-analysis compared total intravenous anesthesia (TIVA) with volatile anesthesia in adults undergoing curative surgery for esophageal or gastric cancer.
Safety and Immunogenicity of the Live-Attenuated Quadrivalent Dengue Vaccine V181 Compared With Butantan-DV Among Healthy Adults in Brazil: A Randomized, Double-Blind, Phase 2 Trial.
This randomized, double-blind, active-comparator phase 2 trial compared the safety and immunogenicity of single-dose quadrivalent dengue vaccines V181 and Butantan-DV in healthy adults in Brazil.
Short- versus long-course antibiotic therapy in non-severe CAP in children: a systematic review and meta-analysis.
This systematic review and meta-analysis compared short-course (≤ 5 days) with longer (> 5 days) antibiotic therapy for non-severe community-acquired pneumonia in immunocompetent children.
Skeletal muscle adaptation to home-based exercise in chronic kidney disease.
This randomized controlled trial examined skeletal muscle responses to a 12-week, personalized home-based exercise program in 25 people with stage 3–5 chronic kidney disease (19 assigned to exercise and 6 to usual…
Safety, Efficacy, and Immunogenicity of a Multivalent Adjuvanted Staphylococcus aureus Vaccine in Adults With Recent Skin and Soft Tissue Infections: An Observer-Blind, Randomized, Placebo-Controlled, Multinational Phase 1/2 Trial.
This observer-blind, randomized, placebo-controlled phase 1/2 trial evaluated a five-antigen Staphylococcus aureus vaccine with AS01E adjuvant in adults, including 194 participants aged 18–64 years with a recent S.
Three Months of Weekly Rifapentine and Isoniazid Versus Four Months of Daily Rifampicin for Tuberculosis Infection: A Randomized Controlled Trial.
This multicenter, open-label randomized controlled trial compared treatment completion with weekly isoniazid plus rifapentine for 3 months (3HP) versus daily rifampicin for 4 months (4RIF) among people of any age with…
Finite Versus Indefinite Nucleos(t)ide Analogue Therapy in HBeAg‑Negative Chronic Hepatitis B: Meta‑Analysis of Randomized Trials.
This meta-analysis evaluated the efficacy and safety of finite versus continuous nucleos(t)ide analogue therapy in HBeAg-negative adults with chronic hepatitis B.
Digital health technologies for the prevention and management of urinary tract infections in menopausal women: A systematic review.
This systematic review synthesised evidence on digital technologies for preventing or managing urinary tract infections in menopausal women.
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