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1357 articles
October 202624
Multimodal MRI markers of white matter hyperintensities and their impact on cognition in cerebral small vessel disease: a systematic review.
This systematic review examined associations between multimodal MRI markers of white matter hyperintensities (WMH) and cognition in adults with cerebral small vessel disease.
Retroperitoneal lymph node dissection for isolated node recurrence of renal cell carcinoma after nephrectomy: a systematic review.
This systematic review assessed perioperative and oncologic outcomes after retroperitoneal lymph node dissection (RPLND) for isolated nodal recurrence of renal cell carcinoma following nephrectomy.
Anticoagulation with the mechanistically distinct FXI/FXIa antibodies amrecibart (REGN9933A2) and cenvacibart (REGN7508Cat).
This Phase I randomised controlled trial programme evaluated two mechanistically distinct factor XI/FXIa monoclonal antibodies as potential anticoagulants, using in vitro assays, nonhuman primates and healthy…
A multicenter randomized phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy in elderly patients with head and neck squamous cell carcinoma unfit for high-dose cisplatin: JCOG2405 (ELDER-WEEKLY).
JCOG2405 (ELDER-WEEKLY) is a planned multicenter, randomized phase III trial comparing radiotherapy plus weekly cisplatin (40 mg/m2) with radiotherapy alone in patients aged ≥70 years with locally advanced head and neck…
Estimating the Economic Value of Supported Online Parent-Led Cognitive Behavioral Therapy to Prevent Child Anxiety Problems: Economic Evaluation of the MYCATS Cluster Randomized Controlled Trial.
This economic evaluation alongside the MYCATS parallel-group, superiority cluster randomised trial assessed supported online parent-led cognitive behavioural therapy (OSI+TS) plus usual school practice versus usual…
Real-World Effectiveness of AI-Enabled Clinical Decision Support in Primary Care: Systematic Review.
This systematic review synthesized real-world evaluations of clinician-facing AI-enabled clinical decision support in primary and ambulatory care, covering studies published from 2011 through 2025.
Effects of Blood Pressure Lowering by Hematoma Location in Acute Intracerebral Hemorrhage.
This pooled individual-patient analysis of five international randomised controlled trials examined whether hematoma location modifies the effect of early intensive blood pressure lowering in acute intracerebral…
Astrocytic and Axonal Injury Biomarkers in AQP4 Antibody-Positive NMOSD: Insights From PREVENT and CHAMPION-NMOSD.
This biomarker analysis used samples from the phase 3 PREVENT and CHAMPION-NMOSD trials to assess serum GFAP and NfL in people with AQP4 antibody-positive NMOSD receiving eculizumab or ravulizumab.
The relationship between fear of negative evaluation and social anxiety: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the association between fear of negative evaluation (FNE) and social anxiety (SA) across 143 studies and 146 independent samples, including 80,285 participants.
Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial.
RAPIDe-3 was a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial of oral deucrictibant for on-demand treatment of hereditary angioedema attacks.
Values, preferences, and treatment burden for initiation of GLP-1 receptor agonists, SGLT-2 inhibitors, tirzepatide, and finerenone in adults with type 2 diabetes: systematic review.
This systematic review synthesised quantitative and qualitative evidence on treatment values, preferences, and perceived burden among adults with type 2 diabetes considering GLP-1 receptor agonists, SGLT-2 inhibitors…
Comparative efficacy of CLDN18.2-directed regimens in advanced gastric/gastroesophageal junction adenocarcinoma: a meta-analysis of single-arm trials.
This meta-analysis pooled results from 10 single-arm trials involving 710 patients with advanced gastric or gastroesophageal junction adenocarcinoma treated with CLDN18.2-directed regimens.
Effect of amaranth flatbread on maternal anthropometry during pregnancy: Evidence from a cluster-randomized controlled trial in Southern Ethiopia.
This parallel-group, cluster-randomized controlled trial assessed daily amaranth-chickpea flatbread in pregnant women with mild-to-moderate anemia in Southern Ethiopia.
Adverse childhood experiences, cognitive outcomes, and frailty in older adults: a systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between adverse childhood experiences (ACEs) and frailty or cognitive outcomes in middle-aged and older adults.
Evaluation of EVT401, a P2X7 receptor antagonist, in healthy Chinese participants: a first-in-human, double-blind, randomized, placebo-controlled, dose-escalation trial.
This phase I, randomized, double-blind, placebo-controlled dose-escalation trial evaluated oral EVT401, a P2X7 receptor antagonist, in healthy Chinese participants aged 18 to 50 years.
Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial.
This case-cohort biomarker validation study examined whether immunohistochemical expression of c-MET, HLA class II, or CD68 predicted progression-free survival in patients with early-stage classic Hodgkin lymphoma…
Effect of Anterior Quadratus Lumborum Block at the Lateral Supra-Arcuate Ligament Combined with Esketamine on the Quality of Postoperative Recovery After Laparoscopic Radical Surgery for Elderly Patients with Colorectal Cancer: A Randomized Controlled Trial.
This single-centre, randomized, placebo-controlled trial evaluated anterior quadratus lumborum block at the lateral supra-arcuate ligament (QLB-LSAL), low-dose esketamine, or their combination in patients aged 60 years…
Open-label Phase 1 study to evaluate drug-drug interactions between ulonivirine and islatravir in adults without HIV.
This open-label, three-period Phase 1 study assessed pharmacokinetic interactions between ulonivirine and islatravir in 36 adults without HIV.
Efficacy and safety of psilocybin-assisted therapy for alcohol use disorder: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of psilocybin-assisted therapy (PAT) for alcohol use disorder.
Comparative effects of inspiratory and expiratory muscle training on diaphragm adaptations and respiratory function in adolescent athletes: a randomized-controlled study.
This randomized controlled study compared inspiratory muscle training (IMT) with expiratory muscle training (EMST) in 26 adolescent female volleyball players.
Determinants of unwitnessed out-of-hospital cardiac arrest: a systematic review (HL-D-26-00618).
This systematic review synthesized observational studies of demographic, socioeconomic, clinical, and situational factors associated with witnessed status among adults with out-of-hospital cardiac arrest (OHCA).
Association between complement de-escalation and prognosis in sepsis: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether reduced complement activation after treatment was associated with prognosis in patients with sepsis. Eleven studies were included.
Frozen section analysis assisted MRI targeted prostate biopsy - results of the randomized clinical FAST trial.
The prospective randomized FAST trial compared frozen section analysis (FSA)-guided, primarily MRI-targeted prostate biopsy with standard combined targeted and systematic biopsy in men with PI-RADS ≥ 4 lesions.
Intracerebral stimulation inducing emotions in SEEG: a systematic review.
This systematic review examined subjective emotional responses to direct intracerebral stimulation during SEEG, synthesizing 34 publications (21 cohort studies and 13 clinical cases) involving 2434 patients and 14,492…
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