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1382 articles

April 20264

Clinical ResearchHematology

The association between serum trace elements and iron deficiency anemia in children and adolescents: a systematic review and meta-analysis.

This systematic review and meta-analysis examined serum iron, zinc, copper, and magnesium in children and adolescents with iron deficiency anemia (IDA), using observational studies identified through January 2025.

HematologyApr 1, 2026Read summary
Clinical ResearchPediatricsOpen access

Meta-analysis of the efficacy of palivizumab versus nirsevimab at preventing medically attended respiratory syncytial virus infections in non-hospitalized preterm infants.

This systematic review and meta-analysis assessed prophylaxis against medically attended, non-hospitalized respiratory syncytial virus (RSV) infections (MARI) and RSV-related hospitalization in healthy infants born at…

Hum Vaccin ImmunotherApr 1, 2026Read summary
Clinical ResearchPediatrics

Efficacy of 38% Silver Diamine Fluoride (SDF) versus Atraumatic Restorative Treatment (ART) in Arresting Dental Caries in Paediatric Patients: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed whether 38% silver diamine fluoride (SDF) arrests dental caries in paediatric patients compared with atraumatic restorative treatment (ART) or placebo.

Eur J Paediatr DentApr 1, 2026Read summary
Clinical ResearchPediatrics

Effect of Preoperative Ibuprofen on Pain Perception and Pulse Rate in Paediatric Patients with Deep Caries: A Randomised Controlled Trial.

This randomised controlled trial evaluated whether preoperative ibuprofen reduces pain and stress responses during vital pulp therapy in 44 children aged 7–13 years with reversible pulpitis in mandibular first permanent…

Eur J Paediatr DentApr 1, 2026Read summary

March 202620

Clinical ResearchPediatrics

A Randomized Trial Testing a Body-Focused Exposure Treatment of Functional Abdominal Pain in Children.

This randomized clinical trial compared two 10-week interventions for functional abdominal pain in 107 parent-child dyads, with children aged 5–9 years.

Am J GastroenterolMar 31, 2026Read summary
Clinical ResearchPediatrics

Outcome evaluation of the Web-based early intervention for children with motor difficulties aged 3-8 years old using multimodal rehabilitation: results of a family-centered pragmatic randomized controlled study.

This pragmatic randomized controlled trial compared WECARE, a web-based, family-centered multimodal rehabilitation intervention, with usual care in 118 families of children aged 3–8 years with motor difficulties.

Disabil RehabilMar 30, 2026Read summary
Case ReportMedical Genetics

A novel case of Heimler syndrome in a young child with compound heterozygous PEX26 mutations: clinical and genetic insights with literature review.

A male infant born at 36 weeks had congenital bilateral sensorineural hearing loss, confirmed by abnormal auditory brainstem responses, and received bilateral cochlear implants.

Ophthalmic GenetMar 29, 2026Read case
Clinical ResearchPediatricsOpen access

Efficacy and safety of first-line therapies and first-line-based combination therapies for monosymptomatic nocturnal enuresis in children: a network meta-analysis.

This network meta-analysis compared first-line treatments and combination regimens for monosymptomatic nocturnal enuresis in children.

Pediatr NephrolMar 28, 2026Read summary
Clinical ResearchPediatrics

Parent-reported engagement in a home-based, parent-delivered early intervention for infants with unilateral cerebral palsy.

This secondary analysis of the REACH randomized comparison trial examined parent-reported engagement during home-based, parent-delivered early intervention for 90 infants with or at risk for unilateral cerebral palsy.

Disabil RehabilMar 28, 2026Read summary
Clinical ResearchPediatricsOpen access

Motor skills and outcomes of activities and participation in children and adults born preterm without cerebral palsy: A systematic review.

This systematic review examined observational evidence on whether motor skills are associated with activities and participation in children and adults born preterm (< 37 weeks’ gestation) without cerebral palsy.

Dev Med Child NeurolMar 27, 2026Read summary
Case ReportPediatrics

Necrotizing Enterocolitis as a Rare Complication of Severe RSV Bronchiolitis in a Term Neonate: A Case Report With Narrative Review.

A previously healthy, full-term 24-day-old neonate was admitted with severe respiratory syncytial virus (RSV) bronchiolitis.

J Pediatr Health CareMar 26, 2026Read case
Clinical ResearchPediatrics

The Utility of Transcutaneous Bilirubin Measurement in Newborns with Hyperbilirubinemia: A Prospective, Observational Study during and after Phototherapy.

This prospective observational study assessed transcutaneous bilirubin (TcB) accuracy during phototherapy and 12 and 24 hours after treatment in term and late-preterm newborns.

Am J PerinatolMar 26, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Social Network Intervention in Physical Education Classes Through Social Support to Promote Physical Activity and Reduce Screen Time in Adolescents: A Cluster Randomized Controlled Trial.

This cluster-randomized controlled trial tested a ten-week, segmentation-based social network intervention in physical education classes at four schools, involving 787 adolescents.

Res Q Exerc SportMar 25, 2026Read summary
Clinical ResearchNephrologyOpen access

Assessment of subclinical atherosclerosis and cardiovascular disease in children and adolescents with nephrotic syndrome: a systematic review and meta-analysis.

This systematic review and meta-analysis examined subclinical atherosclerosis and cardiovascular markers in children and adolescents under 18 years with nephrotic syndrome (NS), compared with healthy controls.

Pediatr NephrolMar 25, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Effectiveness of therapeutic exercise programs on balance and gait in children and adolescents with unilateral cerebral palsy: A systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis of randomized controlled trials assessed therapeutic exercise programs for balance and gait in children and adolescents aged 2–18 years with unilateral cerebral palsy.

Clin RehabilMar 25, 2026Read summary
Clinical ResearchPlastic Surgery

Effectiveness of digitally- versus conventionally-fabricated nasoalveolar molding appliances for presurgical approximation of complete cleft lip and palate: A systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis compared digitally and conventionally fabricated nasoalveolar molding (NAM) appliances for presurgical cleft approximation in infants with complete cleft lip and palate.

J Stomatol Oral Maxillofac SurgMar 25, 2026Read summary
Clinical ResearchPediatrics

Artificial intelligence in Prechtl's General Movements Assessment: A systematic review and meta-analysis.

This systematic review and meta-analysis assessed AI-assisted Prechtl General Movements Assessment (GMA) for predicting later cerebral palsy (CP) and classifying expert-rated GMA labels.

J Neonatal Perinatal MedMar 25, 2026Read summary
Case ReportPediatricsOpen access

Recurrent pancreatitis and atypical hemolytic uremic syndrome (aHUS): an unusual presentation in childhood.

A 10-year-old boy presented with abdominal pain, vomiting, oliguria, and epigastric tenderness during acute pancreatitis accompanied by atypical hemolytic uremic syndrome (aHUS).

Pediatr NephrolMar 24, 2026Read case
Clinical ResearchPediatrics

Safety of excipients in pediatric medications: Impact on child health.

This systematic review examined the safety of common excipients in medicines used for children, drawing on studies published between 2014 and 2025 and information from regulatory agencies.

Farm HospMar 24, 2026Read summary
Case ReportNephrologyOpen access

Intractable dialysis-associated headache: a management dilemma in pediatric hemodialysis.

An adolescent with stage 5 chronic kidney disease and a ventriculoperitoneal shunt developed severe headache during hemodialysis.

Pediatr NephrolMar 24, 2026Read case
Case ReportPathology (Anatomic & Clinical)

An Autopsy Case of Beare-Stevenson Cutis Gyrata Syndrome Presenting with an Extremely Short Small Intestine.

An infant with Beare-Stevenson cutis gyrata syndrome, a craniosynostosis associated with an FGFR2 pathogenic variant, had severe failure to thrive.

Intern MedMar 24, 2026Read case
Clinical ResearchPediatricsOpen access

Influencing factors for severe pertussis among Chinese children: A meta-analysis.

This meta-analysis examined factors associated with severe pertussis among children in China. Searches identified 24 studies, comprising 839 severe and 4,280 non-severe cases.

Hum Vaccin ImmunotherMar 23, 2026Read summary
Case ReportGeneral SurgeryOpen access

The course and surgical management of a complex, giant omphalocele in a term neonate.

A term neonate with a prenatally diagnosed complex, giant omphalocele underwent surgical repair. The defect had an uncommon cystic quality, and its anatomy changed during reduction, making closure challenging.

Proc (Bayl Univ Med Cent)Mar 23, 2026Read case
Clinical ResearchPediatrics

Harnessing Large Language Models in Neonatal Intraventricular Hemorrhage: Exploring Retrieval Augmented Generation Methodology for Prognostic Variable Discovery.

This pilot study combined a systematic literature review with retrieval-augmented generation to assess whether GPT-4 and Claude Sonnet could identify and extract prognostic variables for intraventricular hemorrhage…

Am J PerinatolMar 23, 2026Read summary

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