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464 articles
September 202624
Approved Medications for Substance Use Disorders: An Umbrella Review of Systematic Reviews and Completed Phase 3 Randomized Controlled Trials.
This PROSPERO-registered umbrella review synthesised systematic reviews and completed phase 3 randomised trials of approved and pipeline medications for substance use disorders worldwide.
Housing Instability Associated With Cost-Related Nonadherence and Financial Toxicity in People With Uncontrolled Diabetes.
This randomized controlled trial examined the prevalence of housing instability among 600 adults with uncontrolled diabetes and its impact on cost-related nonadherence and financial toxicity.
Direct oral anticoagulants vs warfarin in Asian vs non-Asian patients with atrial fibrillation: a patient-level meta-analysis from COMBINE AF.
This patient-level meta-analysis compared clinical outcomes of direct oral anticoagulants (DOACs) versus warfarin in 10,212 Asian and 61,471 non-Asian patients with atrial fibrillation.
Semi-recumbent position for the prevention of ventilator-associated pneumonia in adults requiring mechanical ventilation.
This systematic review and meta-analysis evaluated the effectiveness of semi-recumbent positioning for preventing ventilator-associated pneumonia (VAP) in mechanically ventilated ICU patients.
Implementation of a patient-centred complex intervention to improve Initial Medication Adherence to cardiovascular disease and diabetes treatments in primary care (the IMA-cRCT study): a mixed-methods process evaluation.
The IMA-cRCT study evaluated a patient-centred intervention aimed at improving initial medication adherence for cardiovascular disease and diabetes in primary care across 24 Spanish centres.
Barriers and enablers to deprescribing from the perspectives of older adults with polypharmacy and their stakeholders: A systematic review of qualitative studies.
This systematic review synthesised qualitative studies on barriers and enablers to deprescribing among older adults with polypharmacy and relevant stakeholders.
Effect of Semaglutide on Thigh Skeletal Muscle Volume, Fat Infiltration and Physical Function in People With Obesity: Secondary Analysis of STEP UP.
This prespecified secondary analysis of the phase 3b randomised STEP UP trial examined MRI body composition and physical function in adults with obesity assigned to weekly semaglutide or placebo for 72 weeks.
Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients-A Post Hoc Bayesian Analysis of the AID-ICU Trial.
This post hoc analysis of the AID-ICU trial evaluated the effects of haloperidol on delirium subtypes in 987 ICU patients. Haloperidol was linked to more days alive out of hospital, with a 76.5% probability of greater…
Regulatory Mechanisms Within Multicellular Signaling Networks in Liver Ischemia-Reperfusion Injury: A Systematic Review Focusing on Cell-Type-Specific Interactions.
This systematic review examines the regulatory mechanisms within multicellular signaling networks involved in hepatic ischemia-reperfusion injury (HIRI).
Applications of the Early Warning Score as an outcome measure: a systematic review of methodologies.
This systematic review evaluated the use of Early Warning Scores (EWS) as outcome measures in interventional and comparative studies.
"A better system" - managing the adverse effects of prescribed medicines: Cluster-randomised controlled trial and process evaluation of the ADRe Profile in primary care.
This cluster-randomized controlled trial evaluated the ADRe Profile's effectiveness in managing adverse drug reactions among patients aged ≥65 on multiple long-term medications in primary care.
Monitoring strategies in adults eligible for pharmacological lipid-lowering therapy.
This Cochrane systematic review protocol aims to evaluate the effects of various laboratory monitoring strategies on treatment efficacy and safety in adults eligible for pharmacological lipid-lowering therapy.
On the optimal sodium correction rate in hyponatraemia and clinical outcome: a meta-analysis.
This meta-analysis examined the impact of sodium correction rates on mortality in patients with hyponatraemia, analyzing 11 studies with 27,672 cases.
Intractable hepatic hydrothorax eliminated by thoraco-peritoneal connection: A case report.
A 55-year-old female with alcoholic cirrhosis presented with hepatic hydrothorax, characterized by jaundice, anorexia, chest tightness, and shortness of breath.
Infective endocarditis presenting with myocardial infarction with non-obstructive coronary arteries: A case report and literature review.
A 52-year-old male on long-term hemodialysis presented with acute chest pain, shortness of breath, and sweating. Initial ECG showed ST-segment depression, and elevated troponin I levels indicated myocardial infarction.
Helcococcus kunzii as a rare etiological agent of spondylodiscitis partially managed with oral antibiotic therapy in a patient with diabetes mellitus: a case report.
A 62-year-old man with type 1 diabetes mellitus presented with severe lumbar pain, leading to a diagnosis of spondylodiscitis confirmed by MRI.
Wearable Sweat Biosensors for Inflammatory Biomarkers (CRP, IL-6 and TNF-α): A Systematic Review of Analytical and Clinical Evidence.
This systematic review evaluated the use of wearable sweat biosensors for monitoring inflammatory biomarkers (CRP, IL-6, TNF-α) in human studies.
Fatal Cutaneous Mucormycosis Initially Misdiagnosed as Necrotizing Fasciitis in an Uncontrolled Diabetic Patient: A Case Report Highlighting Diagnostic Delay.
A 64-year-old male with undiagnosed diabetes presented with altered consciousness and extensive necrotic lesions, initially diagnosed as bacterial necrotizing fasciitis.
Impact of a standardised music intervention on serum cortisol among sedated, mechanically ventilated adults in the intensive care unit: A randomised controlled trial.
This randomized controlled trial evaluated the impact of a standardized music intervention on serum cortisol levels in sedated, mechanically ventilated adults in the ICU.
Autocrine signaling may regulate exercise-induced interleukin-6 release from human skeletal muscle.
This randomized, double-blind, placebo-controlled trial examined tissue exchange of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) during moderate-intensity cycling in 30 young, well-trained men.
Effect of Sacubitril/Valsartan Versus Angiotensin Receptor Blocker or Calcium Channel Blockers on Ambulatory Blood Pressure and Safety in Hypertensive Patients: A Meta-Analysis of Randomized Controlled Trials.
This meta-analysis of randomized controlled trials assessed sacubitril/valsartan versus angiotensin receptor blockers (ARBs) or calcium channel blockers (CCBs) in people with hypertension.
Haemolytic anaemia and thrombocytopenia following phenobarbital therapy for alcohol withdrawal.
A man in his 50s was admitted for alcohol withdrawal and developed acute anaemia and thrombocytopenia shortly after starting phenobarbital.
Evolving idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever/hyperinflammation, renal dysfunction and organomegaly presenting with severe hypoalbuminaemia, serositis and bicytopenia before lymphadenopathy.
A man in his early 60s presented with abdominal symptoms, severe hypoalbuminaemia, thrombocytopenia, and marked inflammation, without evident lymphadenopathy.
AI-Based Sepsis Prediction in Hospitalized Adults: Systematic Review, Subgroup Meta-Analysis, and Contextual Analysis of Clinical Burden.
This systematic review and meta-analysis evaluated machine learning (ML) and deep learning (DL) models for sepsis prediction in hospitalized adults, analyzing 34 studies.
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