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2000 articles
August 202624
Olaparib maintenance versus placebo or standard of care in ovarian cancer: a biomarker-driven systematic review and meta-analysis of randomized trials.
This systematic review and meta-analysis evaluated the efficacy and safety of olaparib maintenance therapy in advanced ovarian cancer patients who responded to platinum-based chemotherapy.
Early regression index-guided adaptive dose escalation in locally advanced rectal cancer: results of the prospective THUNDER-2 trial.
The THUNDER-2 trial evaluated the effectiveness of Early Regression Index (ERI)-guided adaptive dose escalation in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy.
Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients.
This phase II clinical trial evaluated the efficacy and tolerability of pegtarazimod in patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD).
Effects of five-element music therapy on chemotherapy patients with cancer: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of Five-Element Music Therapy (FEMT) on emotional state, sleep quality, and quality of life in 1588 cancer patients undergoing chemotherapy.
Primary central nervous system T cell lymphoma involving multiple brain and spinal cord lesions with SETD2 mutation.
A 37-year-old Japanese man presented with impaired consciousness, and imaging revealed multiple contrast-enhancing lesions in the brain and spinal cord.
Longitudinal Molecular Characterization of a Rare TPM3::PDGFRB-Rearranged Myeloid/Lymphoid Neoplasm With Late CNL-Like Neutrophilic Evolution.
An elderly patient presented with hypereosinophilia and a balanced t(1;5)(q21;q33), with PDGFRB rearrangement detected in 70% of nuclei.
Multimodal Management of Advanced Metastatic Prostate Cancer: Excellent Response Following Resection of Brain Metastasis and 177Lu-PSMA Therapy.
A 68-year-old man with metastatic prostate adenocarcinoma underwent various treatments, including androgen-deprivation therapy and chemotherapy.
A Phase 1/2 study of ontorpacept (TTI-621) in combination with doxorubicin in patients with unresectable or metastatic high-grade leiomyosarcoma.
This multicentre Phase 1/2 clinical trial evaluated ontorpacept, a CD47–SIRPα pathway inhibitor, with doxorubicin in adults with advanced high-grade soft-tissue sarcoma; Phase 2 enrolled patients with high-grade…
Reconstruction of a Base of Fifth Metacarpal Tumor Using the Dubert Procedure: A Case Report.
A 63-year-old right-hand-dominant man was referred for reconstruction after intralesional resection of a myopericytic neoplasm at the base of the left fifth metacarpal.
Moderating Role of Perceived Neighborhood Environment on Physical Activity and BMI Outcomes of a Diet and Physical Activity Intervention Among Latina Breast Cancer Survivors.
This secondary analysis of a randomized trial examined whether perceived neighborhood aesthetics and walkability modified diet and physical activity intervention outcomes among 86 urban Latina breast cancer survivors.
Molecular evaluation of residual disease following neoadjuvant chemotherapy in triple-negative breast cancer CALGB 40603 (Alliance).
This phase II randomized controlled trial evaluated residual disease (RD) in 340 pretreatment and 70 posttreatment samples from patients with triple-negative breast cancer (TNBC).
Modified endoscopic mucosal resection versus endoscopic submucosal dissection for rectal neuroendocrine tumors ≤10 mm: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy of modified endoscopic mucosal resection (m-EMR) versus endoscopic submucosal dissection (ESD) for rectal neuroendocrine tumors (r-NETs) ≤10 mm, involving…
Modulatory role of Blastocystis-derived solubilized antigens in colorectal carcinogenesis: A systematic review.
This systematic review examined the immunomodulatory effects of Blastocystis-derived solubilized antigens (BSA) on colorectal cancer (CRC) using six experimental studies.
Bispecific Antibodies Are Associated With Progressive Multifocal Leukoencephalopathy.
This report details five patients with relapsed and refractory multiple myeloma who developed progressive multifocal leukoencephalopathy (PML following treatment with bispecific antibodies.
Primary Cutaneous Anaplastic Large Cell Lymphoma in a Patient With Li Fraumeni Syndrome.
A 64-year-old man with Li-Fraumeni syndrome and a germline TP53 p.R196* mutation presented with a solitary ulcerated nodule on the left anterior thigh.
Darolutamide Alone and in Combination With Goserelin in Androgen Receptor-Positive Salivary Gland Carcinoma: Results From the Phase II DISCOVARY Trial.
The phase II DISCOVARY trial evaluated darolutamide, both alone and with goserelin, in patients with androgen receptor-positive unresectable locally advanced or recurrent/metastatic salivary gland carcinoma.
Safety and Efficacy of Psilocybin During Anticancer Treatment: A Phase II Trial Secondary Analysis.
This phase II trial secondary analysis evaluated the safety and efficacy of psilocybin-assisted therapy in cancer patients with major depressive disorder, comparing those receiving systemic anticancer treatment to those…
Selective Transarterial Embolization for Refractory Bleeding in Advanced Scalp Angiosarcoma: Two Cases.
Two 75-year-old patients with advanced scalp angiosarcoma developed persistent bleeding from ulcerated, progressive tumors despite prior cancer treatment.
Efficacy and tolerability of sodium-glucose cotransporter-2 inhibitors in transthyretin amyloid cardiomyopathy: A systematic review and stratified meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and tolerability of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with transthyretin amyloid cardiomyopathy (ATTR-CM).
A systematic review and meta-analysis of radiation-induced oral complications in head and neck cancer: Prevalence and clinical outcomes.
This systematic review and meta-analysis evaluated the prevalence of radiation-induced oral complications, specifically xerostomia and oral mucositis, in head and neck cancer patients undergoing radiotherapy.
Clinical Heterogeneity and Long-Term Outcomes of Pediatric Gastrointestinal Stromal Tumors: A Series of Four Patients Highlighting SDH-Deficient and SDH-Intact Subtypes.
This report details four pediatric patients with gastrointestinal stromal tumors (GISTs) over 19 years. Two patients had SDH-deficient tumors, with one experiencing metastatic relapse.
Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial.
This secondary analysis of a multicenter clinical trial compared surgical management and outcomes by age among patients with high-risk, stage II–III breast cancer who received neoadjuvant systemic therapy.
Natural Killer Cell Immunotherapy After Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia Patients: Phase I Clinical Trial.
This Phase I clinical trial evaluated the safety and efficacy of interleukin-15-activated CD56+ cell infusion in patients with acute leukemia post-allogeneic hematopoietic stem cell transplantation.
Metastatic Gastrointestinal Neuroectodermal Tumor Mimicking a Benign Hepatic Hemangioma on MRI: Role of 18 F-FDG PET/CT.
A 27-year-old man with proximal jejunal gastrointestinal neuroectodermal tumor (GNET) underwent segmental resection and adjuvant chemotherapy.
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