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2000 articles
August 202624
Clinical Reasoning: A 79-Year-Old Man With Subacute Onset Involuntary Facial Movements and Discoordination.
A 79-year-old man with metastatic Merkel cell carcinoma undergoing cancer-directed treatment was admitted to the hospital with 1 week of bilateral upper and lower extremity tremor and nearly continuous involuntary…
Multidisciplinary treatment with conversion surgery after radiological complete response of liver metastasis to gemcitabine, cisplatin, and durvalumab in metastatic distal cholangiocarcinoma.
A 73-year-old woman with prior total gastrectomy was diagnosed with distal cholangiocarcinoma and a solitary liver metastasis.
Multifocal primary hepatic epithelioid hemangioendothelioma: a case in which tumor biopsy was critical to prevent misdiagnosis.
An 82-year-old woman undergoing postoperative surveillance for bladder cancer was found to have multiple hepatic masses on contrast-enhanced CT.
De-escalation of radiotherapy in HPV-negative non-nasopharyngeal head and neck squamous cell carcinoma: a systematic review.
This systematic review evaluated de-escalation strategies in radiotherapy for HPV-negative non-nasopharyngeal head and neck squamous cell carcinoma (HNSCC).
Prediction of benefit from docetaxel chemotherapy for HR-positive breast cancer in the PACS-01 trial.
This randomized controlled trial evaluated the predictive value of the SET ER/PR index for docetaxel benefit in node-positive, hormone receptor-positive breast cancer patients from the PACS-01 trial.
A rare case of cytomegalovirus mucositis resembling an immune-related adverse event during treatment with nivolumab and ipilimumab.
A 79-year-old man with malignant melanoma of the sphenoid sinus was treated with nivolumab and ipilimumab. He developed immune-related colitis, treated with corticosteroids and infliximab.
Detection of an inflammatory myofibroblastic tumor in the testis by FDG-PET/CT; a rare presentation of a rare neoplasm.
FDG-PET/CT in a 73-year-old man revealed incidental FDG accumulation in the left testicle which was eventually diagnosed as an inflammatory myofibroblastic tumor (IMT): a rare localization of a rare tumor.
Longitudinal Change in Cardiac Function After Doxorubicin and Dexrazoxane: A Report From Children's Oncology Group ALTE11C2.
This randomized controlled trial analyzed echocardiographic data from 895 childhood cancer survivors treated with doxorubicin, assessing the long-term effects of dexrazoxane on cardiac function.
Conversion strategies in RAS wild-type colorectal liver metastases: a systematic review and meta-analysis of first-line trials comparing regimens with anti-epidermal growth factor receptor inhibitors versus bevacizumab.
This systematic review and meta-analysis compared first-line chemotherapy combined with an EGFR inhibitor or bevacizumab in patients with RAS wild-type metastatic colorectal cancer and liver-limited disease, focusing on…
Uncovering an uncommon diagnosis: Encapsulated papillary carcinoma of the male breast in a Jordanian patient-A case report.
A 58-year-old male presented with a stable, non-painful left breast mass, initially misdiagnosed as a lipoma. Imaging revealed a suspicious BIRADS 4 mass, and intraoperative frozen section suggested malignancy.
Partial hepatectomy after liver transplantation: systematic review and pooled analysis of indications, techniques and outcomes.
This PRISMA-compliant systematic review and pooled analysis examined indications, surgical approaches and outcomes of partial hepatectomy after orthotopic liver transplantation (OLT), using 16 studies involving 135…
Efficacy of redifferentiation therapy in radioactive iodine refractory thyroid cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed targeted redifferentiation therapy in patients with radioactive iodine (RAI)-refractory thyroid cancer.
Clavicular Osteoradionecrosis With 99mTc-FAPI-46 Uptake in a Patient With Breast Cancer.
A 65-year-old woman with a history of right breast cancer treated with mastectomy and chemoradiotherapy later developed cervical and supraclavicular metastatic disease and a left supraclavicular ulcer.
Health-Related quality of life (HRQoL) and health state utility values (HSUV) in patients with head and neck Cancer: A systematic review and Meta-Analysis.
This systematic review and meta-analysis evaluated health-related quality of life (HRQoL) and health state utility values (HSUV) in 7,403 patients with head and neck cancer (HNC).
Secondary Ameloblastic Carcinoma With Craniofacial and Skull Base Invasion: En Bloc Resection and Dural Reconstruction.
A 27-year-old male with a 13-year history of recurrent mandibular ameloblastoma presented with extensive craniofacial progression and regional lymph node metastases.
Assessing Graded Histological Regression as Basis for Treatment Modification after Neoadjuvant Therapy in LAGC: An Exploratory Phase II Study.
This prospective, single-centre, open-label, randomised phase II trial assessed whether graded histologic regression (GHR) below 50% could guide adjuvant chemotherapy modification in locally advanced gastric cancer…
Obstructed by Metastasis: Dual Biliary and Gastric Outlet Obstruction from Metastatic Breast Carcinoma.
A 57-year-old woman with a history of HER2-positive, hormone-receptor-negative breast carcinoma treated four years earlier presented with jaundice, vomiting, early satiety, and weight loss.
SKYSCRAPER-03: a phase III study of tiragolumab plus atezolizumab versus durvalumab in locally advanced, unresectable, stage III NSCLC after platinum-based concurrent chemoradiation.
SKYSCRAPER-03 was a phase III, open-label, randomized trial comparing consolidation tiragolumab plus atezolizumab with durvalumab after platinum-based concurrent chemoradiation in patients with locally advanced…
Risk-stratified management of the clinically node-negative neck in early-stage oral squamous cell carcinoma: Elective neck dissection versus watch-and-wait with therapeutic dissection.
This systematic review evaluated the management of clinically node-negative (cN0) neck in early-stage oral squamous cell carcinoma (OSCC) by comparing elective neck dissection (END) to a watch-and-wait (W&W) approach…
Liquid Biopsy in Head and Neck Squamous Cell Carcinoma: A Systematic Review of the Scientific Literature.
This systematic review evaluates the role of liquid biopsy in head and neck squamous cell carcinoma (HNSCC), focusing on circulating tumor cells, ctDNA, and RNA biomarkers.
Primary Pulmonary Diffuse Large B-cell Lymphoma.
A 72-year-old man presented with two weeks of fever and mild upper respiratory symptoms. Initial CT and ¹⁸F-FDG PET/CT showed only nonspecific dependent ground-glass opacities (GGO).
Bacillus Calmette-Guérin (BCG) with or without immune checkpoint blockade in BCG-naïve high-risk non-muscle-invasive bladder cancer: A systematic review and reconstructed individual patient data meta-analysis.
This systematic review and reconstructed individual patient data meta-analysis pooled three phase 3 randomised trials involving 2,590 patients with BCG-naïve high-risk non-muscle-invasive bladder cancer.
Efficacy and safety of the BEBM (bendamustine, etoposide, busulfan, and melphalan) conditioning regimen for autologous stem-cell transplantation in non-Hodgkin lymphoma.
This phase I, 3 + 3 dose-escalation study assessed adding melphalan to bendamustine, etoposide, and busulfan conditioning for autologous stem-cell transplantation in 12 patients with high-risk or relapsed/refractory…
Trametinib-mediated MEK inhibition impairs cancer cell viability and invasion in patient-derived tumor avatars of glioblastoma with extraneural metastases: A proof-of-concept study.
A patient with glioblastoma (GBM) presented with rare extraneural metastases, characterized by aggressive molecular features including alterations in NF1, TP53, PTEN, and RB1.
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