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2000 articles
August 202624
Biomarker-Stratified Phase II Trial of Trastuzumab Rezetecan in Advanced Salivary Gland Carcinoma Across Cohorts With High and Low Human Epidermal Growth Factor Receptor 2 Expression.
This phase II trial evaluated trastuzumab rezetecan in patients with unresectable advanced salivary gland carcinoma (SGC), stratified by HER2 expression levels.
Neoadjuvant Intralesional Daromun (L19IL2/L19TNF) in Resectable Locally Advanced Melanoma: An Update on the Efficacy and Safety Results of the PIVOTAL Phase III Trial.
The PIVOTAL Phase III trial evaluated the efficacy and safety of neoadjuvant intralesional daromun (L19IL2/L19TNF) in 256 patients with fully resectable stage III melanoma.
Stage shift, histological differentiation, and survival patterns of lung squamous cell carcinoma versus adenocarcinoma in low-dose CT screening.
This randomized controlled trial compared stage shift, histological differentiation, and survival patterns between lung squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD) in low-dose CT (LDCT) screening.
Patient-reported outcomes with tisotumab vedotin versus chemotherapy in patients with recurrent or metastatic cervical cancer: post hoc analyses from the open-label, randomized, phase 3 ENGOT-cx12/GOG-3057/innovaTV 301 trial.
This post hoc analysis of the open-label, randomized, phase 3 innovaTV 301 trial examined patient-reported health-related quality of life among patients receiving second- or third-line treatment for recurrent or…
The effects of mindfulness-based cognitive therapy in the psychological and physical health of cancer patients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of mindfulness-based cognitive therapy (MBCT) on psychological and physical health in cancer patients.
suPAR as a circulating inflammatory biomarker: time for translation into clinical practice - A systematic review.
This systematic review examines soluble urokinase-type plasminogen activator receptor (suPAR) as a circulating biomarker, its isoforms, and methods used to measure it.
68 Ga-FAPI-04 PET/CT Detection of Peritoneal Metastases From a Rare Uterine Tumor Resembling Ovarian Sex-cord Tumor.
Uterine tumor resembling ovarian sex-cord tumor (UTROSCT) is an extremely rare uterine stromal neoplasm of uncertain origin that accounts for less than 0.5% of uterine malignancies.
Mismatch repair protein expression as a prognostic factor in head and neck squamous cell carcinoma: A systematic review.
This systematic review assessed whether mismatch repair (MMR) protein expression predicts outcomes in patients with head and neck squamous cell carcinoma (HNSCC).
Artificial intelligence-supported double reading in European population breast cancer screening: A systematic review and meta-analysis of prospective programs.
This meta-analysis evaluated the impact of artificial intelligence (AI) on breast cancer screening in European populations, synthesizing data from three large studies.
From human papillomavirus (HPV) infection to HPV-associated cancers in systemic lupus erythematosus: A systematic review and Meta-analysis.
This systematic review and meta-analysis evaluated the risk of HPV infection and associated cancers in patients with systemic lupus erythematosus (SLE).
Disseminated Salmonella infection associated with secondary seeding of an indwelling central venous catheter during chemotherapy-induced neutropenia.
A patient undergoing outpatient chemotherapy for a gynecological malignancy developed a disseminated Salmonella infection, likely acquired from fresh confectionery.
Parkinsonism as a Potential Neurologic Immune-Mediated Adverse Event of Immune Checkpoint Inhibitors.
Immune checkpoint inhibitor (ICI)-related parkinsonism is an exceedingly rare neurologic immune-related adverse event (irAE).
Diffuse Long-segment Colonic Wall Thickening Mimicking Abdominal Tuberculosis: A Diagnostic Challenge Revealing Signet Ring Cell Carcinoma in a 24-year-old Male.
A 24-year-old man with long-standing abdominal pain had contrast-enhanced CT showing target-like diffuse bowel-wall thickening from the terminal ileum through the entire transverse colon, with ascites and omental…
Dual‑targeted radioligand therapy with [ 177 Lu]Lu‑DOTATATE plus [ 177 Lu]Lu‑DOTA‑IBA for bone metastases from neuroendocrine neoplasms: a prospective pilot study.
This prospective, single-centre, single-arm pilot study evaluated combined [177Lu]Lu-DOTATATE and [177Lu]Lu-DOTA-IBA in 30 patients with neuroendocrine neoplasms and bone metastases.
Inflammation hinders anabolic potential of nutritional support in cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) trial.
The PRIMe trial analyzed the impact of baseline inflammation on the effectiveness of high-protein nutritional support in patients with stage II-IV colorectal cancer.
Metabolic Tumor Volume Is More Accurate Than SUV Metrics in PSMA-PET/CT Analysis Across Different PET/CT Scanners.
A 66-year-old man with metastatic prostate cancer had PSMA-avid local recurrence on follow-up PSMA-PET/CT and MRI. Across three PET studies, SUVmax, SUVmean, and total lesion glycolysis (TLG) did not track consistently…
A Case of FDG-Avid but FAPI-Negative Peritoneal Metastatic Gastrointestinal Stromal Tumor.
An 80-year-old man with a biopsy-confirmed metastatic gastrointestinal stromal tumor underwent both 18F-FDG PET/CT and 68Ga-FAPI PET/CT imaging.
Effects of different resistance exercise programs on upper limb functional recovery in postoperative breast cancer patients.
This randomized controlled trial examined the impact of grip strength exercises combined with upper limb resistance exercises on functional recovery in 111 postoperative breast cancer patients.
Nivolumab plus chemotherapy or ipilimumab versus chemotherapy as first-line treatment for advanced esophageal squamous cell carcinoma: 5-year follow-up results from CheckMate 648.
This open-label, phase III randomized trial compared first-line nivolumab plus chemotherapy, nivolumab plus ipilimumab, and chemotherapy in patients with previously untreated, unresectable advanced, recurrent, or…
Therapeutic targeting of folate receptor alpha (FRα) by antibody-polymer-drug conjugate in testicular germ cell tumors.
Antibody-drug conjugates (ADCs) are an effective treatment for recurrent/refractory testicular germ cell tumors (rrTGCTs). In this exploratory study, we report disease stabilization achieved with the ADC Mirvetuximab…
Ultra-hypofractionated versus conventional chemoradiation for newly diagnosed glioblastoma: Survival and toxicity results of a multicenter randomized trial.
This phase III randomized trial evaluated the non-inferiority of ultra-hypofractionated chemoradiation (6x6Gy) versus standard chemoradiation (30x2Gy) in adults with newly diagnosed glioblastoma.
Time-restricted eating to entrain circadian rhythms, increase physiological responsiveness, and prevent stressor-induced frailty: A pilot randomized controlled trial.
This pilot randomized controlled trial assessed the feasibility of daytime-aligned time-restricted eating (TRE) and exploratory supportive-care outcomes in adults aged 55 years or older receiving treatment for prostate…
Dissecting a Diagnostic Enigma, Multiple Bilateral Facial Nodules in a Middle Aged Woman.
A 40-year-old woman presented with multiple bilateral facial nodules in a zosteriform pattern, which had increased over 15 years.
Pain response after palliative-intent radiotherapy for pancreatic cancer: a systematic review.
This systematic review evaluated the effectiveness of palliative-intent radiotherapy (RT) for pain relief in pancreatic cancer patients.
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