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1357 articles
October 202624
Effectiveness of different autologous platelet concentrates for orthodontic canine retraction following premolar extraction: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed platelet-rich plasma (PRP), injectable platelet-rich fibrin (i-PRF), and leukocyte-platelet-rich fibrin (L-PRF) for accelerating orthodontic canine retraction after…
Artificial intelligence-enhanced electrocardiography for predicting mortality and major adverse cardiovascular events: A systematic review and narrative synthesis.
This systematic review and narrative synthesis evaluated AI-enabled 12-lead or single-lead ECG models for predicting all-cause mortality, cardiovascular mortality, and major adverse cardiovascular events in adults.
Hyaluronic acid-based skin booster with glutathione combined with 1064-nm Nd:YAG laser and oral tranexamic acid for melasma: A prospective comparative study.
This randomized comparative study evaluated whether intradermal hyaluronic acid-based glutathione (HA-GSH) improves outcomes when added to low-fluence 1064-nm Q-switched Nd:YAG laser and oral tranexamic acid in Chinese…
Effectiveness of Discrete Strategies and Implementation Bundles for Improving Clinician Prescription of Clinical Practice Guideline-Recommended Medications for Atherosclerotic Occlusive Disease: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed randomized trials of strategies to improve prescription of guideline-strongly-recommended medications for adults with atherosclerotic occlusive disease.
SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis.
This PRISMA-guided systematic review and meta-analysis assessed SOX10 immunohistochemical expression across primary salivary gland tumors. It included 35 studies comprising 1146 histological and 35 cytological samples.
Effectiveness of traditional mind-body exercises on fall risk test scores and balance in older adults: A systematic review and meta-analysis.
This systematic review and meta-analysis pooled 31 randomized controlled trials involving 3,622 older adults to assess traditional mind-body exercises and fall-risk test scores and balance.
Dapagliflozin After Transcatheter Aortic Valve Implantation According to Frailty in DapaTAVI Trial.
This post hoc analysis of the multicenter randomized DapaTAVI trial examined whether frailty modified dapagliflozin’s effects after transcatheter aortic valve implantation.
SGLT2 inhibitors in diabetic biopsy proven MASH patients: A systematic review and meta-analysis.
This systematic review and random-effects, single-arm meta-analysis assessed SGLT2 inhibitors in patients with diabetes and biopsy-proven MASH. Seven trials contributed 110 patients receiving the intervention.
Multicenter Phase I Study of Triapine in Combination with [177Lu]Lutetium-Dotatate in Patients with Well-Differentiated Neuroendocrine Tumors (ETCTN 10388).
This multicenter phase I dose-escalation and dose-expansion study evaluated [177Lu]lutetium-dotatate plus oral triapine in patients with well-differentiated gastroenteropancreatic neuroendocrine tumors.
Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial.
This multicenter, phase I trial evaluated multiantigen stimulated cell therapy I (MASCT-I), alone or with ifosfamide, as first-line maintenance therapy in 31 patients with advanced sarcoma whose disease was controlled…
Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial.
This randomized phase II trial biomarker analysis evaluated circulating thymidine kinase activity (TKa) in patients with BRAF V600-mutated metastatic melanoma receiving targeted therapy (TT), immune checkpoint…
Feasibility and Activity of Concurrent Neoadjuvant Chemotherapy and Radiotherapy in Patients with High-risk Soft-Tissue Sarcoma.
This analysis of the international, randomized phase III ISG-STS 1001 trial assessed concurrent epirubicin–ifosfamide chemotherapy (EI) and radiotherapy in patients with localized, high-risk soft-tissue sarcoma.
Weight Loss Responses to Pharmacotherapy in Breast Cancer Survivors: Results from the Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study.
This single-arm phase II study evaluated behavioral weight loss (BWL), with Contrave added for women with prior stage 0 to III breast cancer who lost less than 5% of their weight after two months.
FDA Approval Summary: Retifanlimab for the Treatment of Adult Patients with Metastatic or Inoperable Locally Recurrent Squamous Cell Carcinoma of the Anal Canal.
This FDA approval summary describes evidence from POD1UM-303, a randomised trial in 308 patients with advanced squamous cell carcinoma of the anal canal (SCAC) and no prior systemic treatment for advanced disease, and…
Rilvegostomig for Metastatic Non-Small Cell Lung Cancer: A First-In-Human Phase I/II Clinical Study.
This first-in-human, multicenter, open-label phase I/II study evaluated rilvegostomig, a bispecific antibody targeting PD-1 and TIGIT, in patients with PD-L1-positive advanced or metastatic non-small cell lung cancer…
Efficacy and Safety of Necitumumab and Pembrolizumab Combination Therapy in Advanced Non-Small Cell Lung Cancer with ≥50% PD-L1 Expression: A Nonrandomized Phase II Trial.
This nonrandomized, multicenter, open-label, single-arm phase II trial evaluated first-line pembrolizumab plus necitumumab in 50 patients with previously untreated advanced NSCLC and PD-L1 tumor proportion score ≥50%.
Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics.
This single-centre, open-label phase I trial assessed intravenous autologous IL13Rα2-targeted CAR T cells in adults with recurrent, IL13Rα2-expressing grade 3–4 gliomas after standard treatment.
Peripheral Nerve Stimulation for Essential Tremor: a Systematic Review and Meta-Analysis of Effectiveness and Safety.
This systematic review and meta-analysis assessed peripheral nerve stimulation (PNS), including transcutaneous afferent patterned stimulation and transcutaneous peripheral nerve stimulation, for essential tremor.
Epididymal cysts in children: a systematic review and meta-analysis of treatment approaches and clinical outcomes.
This PRISMA-compliant systematic review and meta-analysis synthesised observational evidence on epididymal cysts in boys younger than 18 years.
Conservative Outcomes of Subtalar Dislocation: A Systematic Review and Meta-Analysis of the Current Literature.
This systematic review and meta-analysis assessed outcomes after closed reduction and immobilisation of acute isolated subtalar dislocations.
Global Underutilization of Antiviral Therapy and Survival Outcomes in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of 78 Studies and 68,243 Patients.
This systematic review and meta-analysis assessed antiviral use and its association with survival and hepatocellular carcinoma (HCC) recurrence in adults with HBV-related HCC.
Predicting neurodevelopmental delay among two-year-old infants in Northern Uganda.
This study developed and evaluated a risk-prediction model for neurodevelopmental delay among two-year-old children in Northern Uganda.
Evidence on Glutathione and Boosters for Prevention of Chemotherapy-Induced Neuropathy: A Systematic Review and Network Meta-Analysis.
This systematic review and network meta-analysis compared glutathione (GSH) and GSH boosters for preventing chemotherapy-induced peripheral neuropathy (CIPN), drawing on 25 randomised controlled trials involving 1625…
Optimizing Autologous Fat Grafting: A Systematic Review of Enhancement Strategies and Graft Survival.
This systematic review assessed strategies for enriching autologous fat grafts to improve graft survival, drawing on animal and clinical studies published through February 2025.
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