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2000 articles
August 202624
Ivonescimab in combination with chemotherapy in advanced or metastatic gastric cancer (GC) or esophagogastric junction cancer (EGJC): The UCGI 52 - GRACIE trial.
The GRACIE trial is a multicenter, open-label phase II study evaluating the efficacy and safety of Ivonescimab combined with FOLFOX chemotherapy in 88 patients with advanced or metastatic gastric cancer or…
Heterogeneous associations of antidiabetic medications with cancer prognosis: Evidence from 61 studies with over 1.1 million patients.
This meta-analysis evaluated the prognostic effects of seven antidiabetic medication classes in over 1.1 million cancer patients, primarily with type 2 diabetes.
Atezolizumab-bevacizumab with or without cisplatin-based HAIC for unresectable HCC: A randomized phase II trial.
This multicenter, open-label, randomized phase II trial compared sequential cisplatin hepatic arterial infusion chemotherapy (HAIC) followed by atezolizumab-bevacizumab with atezolizumab-bevacizumab alone in patients…
Effect of Rivoceranib 200 mg Once Daily on the Pharmacokinetics of a Cocktail Probe Substrate of Cytochrome P450 Enzymes: A Phase I Trial in Healthy Volunteers.
This Phase I trial assessed the impact of rivoceranib 200 mg once daily on the pharmacokinetics of various cytochrome P450 substrates in 18 healthy volunteers.
Successful treatment of refractory hemophagocytic lymphohistiocytosis complicating Epstein-Barr virus-positive classic Hodgkin lymphoma with rituximab.
A male in his early 70s with advanced EBV-positive mixed-cellularity classic Hodgkin lymphoma presented with cervical lymphadenopathy, fever, and hepatosplenomegaly.
A case of diffuse large B-cell lymphoma achieving complete remission with epcoritamab after pseudoprogression.
A 58-year-old male with diffuse large B-cell lymphoma (DLBCL) achieved complete remission after fourth-line therapy but experienced pelvic lymphadenopathy 26 months later, indicating relapse.
Spleen management in hepatectomy for hepatocellular carcinoma with hypersplenism: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared hepatectomy alone (HA), hepatectomy plus splenectomy (HS), and hepatectomy plus splenic arterial flow reduction (SAFR) in patients with hepatocellular carcinoma…
Post-pancreatectomy Liver Injury After Mayo Clinic Class Ia Celiac Axis Resection: Illustration of This Newly Described Entity with Delayed Hepatic Artery Revascularization.
A 59-year-old patient with locally advanced pancreatic body cancer received extended neoadjuvant FOLFIRINOX and underwent pancreatosplenectomy with Mayo Clinic class Ia celiac artery resection.
Implications of Mobile Applications for Breast Surgery: A Systematic Review.
This systematic review evaluated mobile applications designed to assist patients undergoing breast surgery across various stages of care.
Diagnostic Accuracy of Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Differentiating Tumor and Bland Thrombus in Patients With Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed PET/CT accuracy for distinguishing tumor from bland thrombus in adults with cancer, using observational studies with histopathology, confirmatory imaging, or clinical…
Prospective Clinical Trial on Expanding the Eligibility Criteria for Targeted Axillary Dissection after Neoadjuvant Systemic Therapy in Breast Cancers with Advanced Nodal Disease.
This prospective clinical trial evaluated the effectiveness of targeted axillary dissection (TAD) in patients with advanced nodal disease (clinical N1 to N3) undergoing neoadjuvant chemotherapy.
Epithelioid renal angiomyolipoma: Clinical characteristics, treatment strategies, and oncological outcomes-An individual patient data meta-analysis of 259 cases.
This meta-analysis examined 259 cases of epithelioid angiomyolipoma (eAML), a rare malignant renal tumor. The study found a 39% recurrence rate at a median follow-up of 21 months, with significant risk factors including…
Catatonia in a 13-Year-Old With T-Cell Lymphoblastic Lymphoma Following Intrathecal Methotrexate.
A 13-year-old girl with T-cell lymphoblastic lymphoma exhibited agitation, confusion, and catatonia five days after receiving intrathecal methotrexate.
Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial.
The randomized phase II DEEPER trial compared m-FOLFOXIRI plus cetuximab with m-FOLFOXIRI plus bevacizumab in patients with RAS wild-type metastatic colorectal cancer, reporting final survival outcomes and exploratory…
Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm.
A 48-year-old woman presented with an incidental pancreatic head mass. Cytological analysis from endoscopic ultrasound-guided fine-needle aspiration revealed tumor cells with eccentric nuclei and prominent eosinophilic…
What is the prognostic significance of positive lymph nodes at the circumferential resection margin in rectal cancer: a systematic review.
This systematic review examined whether rectal cancer involving the circumferential resection margin (CRM) through metastatic lymph nodes carries the same prognosis as CRM involvement from direct tumor extension.
Generalised eruptive histiocytosis mimicking lymphoma relapse in a patient with previous diffuse large B-cell lymphoma.
A 92-year-old man previously treated for diffuse large B-cell lymphoma, including radiotherapy for a cutaneous relapse, developed asymptomatic erythematous-to-violaceous papules and nodules on his face, trunk, and upper…
Repeated normothermic intraperitoneal paclitaxel perfusion via videolaparoscopy (RIPPENC-VLP) combined with CAPOX for gastric cancer with positive cytology or limited peritoneal metastasis: A prospective phase II study.
This prospective, single-centre phase II study evaluated repeated normothermic intraperitoneal paclitaxel perfusion via videolaparoscopy plus systemic CAPOX in patients with gastric adenocarcinoma and positive…
Polyphyllin I in malignant tumors: molecular mechanisms and advances.
This systematic review examines Polyphyllin I (PPI), a natural product from Rhizoma Paridis, focusing on its antitumor mechanisms and druggability.
A systematic review of Mendelian randomization evidence on alcohol-related phenotypes and multiple human diseases.
This systematic review synthesised Mendelian randomization studies using genetic variants as instruments for alcohol consumption, alcohol use disorder, or related measures to assess associations with health outcomes.
Effect of adding umbilical cord blood derived stem cells to haploidentical stem cell transplant (haplo-cord) on post-transplant survival and graft-versus-host disease in patients with hematological malignancies: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of adding umbilical cord blood-derived stem cells to haploidentical stem cell transplantation (haplo-cord) in patients with hematological malignancies.
Adjuvant pembrolizumab for the treatment of clear cell renal cell carcinoma: five-year results from the phase III KEYNOTE-564 study.
This randomized, multicenter phase III trial evaluated adjuvant pembrolizumab versus placebo after surgery in adults with clear cell renal cell carcinoma at increased risk of recurrence.
SHR-2004, a Humanized Monoclonal Antibody Targeting Factor XI, for Preventing Venous Thromboembolism After Ovarian Cancer Surgery: A Randomized, Active-Controlled Phase 2 Study.
This multicenter, open-label, randomized Phase 2 trial compared the factor XI-targeting antibody SHR-2004 with enoxaparin followed by rivaroxaban for postoperative venous thromboembolism (VTE) prevention in patients…
Image-Guided Thyroid Ablation versus Surgery for T1N0M0 Papillary Thyroid Carcinoma: A Consensus-Aligned Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared image-guided thyroid ablation (IGTA) with surgery for T1N0M0 papillary thyroid carcinoma (PTC).
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