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464 articles

October 20265

Clinical ResearchInfectious DiseasesOpen access

Evaluating plasma ferritin and suPAR as treatable traits for critically ill patients with COVID-19 treated with anakinra: an exploratory analysis of the immune modulation domain of the REMAP-CAP randomised clinical trial.

This exploratory analysis of the REMAP-CAP randomized clinical trial evaluated plasma ferritin and suPAR as potential treatable traits for anakinra in critically ill COVID-19 patients.

Crit CareOct 1, 2026Read summary
Clinical ResearchEndocrinology

A Composite Ovine Forestomach Matrix and Hyaluronic Acid CAMP for the Treatment of Full Thickness Wounds of the Foot in People With Diabetes: A Randomized Controlled Trial.

This randomized controlled trial evaluated the efficacy of a novel composite CAMP, OFM-HA, in treating full thickness diabetic foot ulcers (DFUs) in 143 patients.

Int Wound JOct 1, 2026Read summary
Clinical ResearchCardiology

Efficacy and Safety of Lorundrostat for Uncontrolled and Treatment-resistant Hypertension: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

This systematic review and meta-analysis evaluated the efficacy and safety of lorundrostat in adults with uncontrolled or treatment-resistant hypertension.

J Cardiovasc PharmacolOct 1, 2026Read summary
Clinical ResearchPulmonologyOpen access

Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults: The SAVE-O2 AI Randomized Clinical Trial.

The SAVE-O2 AI randomized clinical trial evaluated the effectiveness of autonomous oxygen titration in maintaining normoxemia in acutely ill adults receiving supplemental oxygen.

JAMA Intern MedOct 1, 2026Read summary
Clinical ResearchCardiology

Effectiveness of a Sodium Intake Monitoring Smartphone Application (NamakBan) on Clinical Outcomes of Patients Diagnosed With Hypertension: A Randomized Clinical Trial.

This randomized clinical trial evaluated the effectiveness of the NamakBan smartphone application for monitoring sodium intake in 88 adults with primary hypertension.

Nurs OpenOct 1, 2026Read summary

September 202619

Clinical ResearchEmergency Medicine

Reducing Peripheral Intravenous Catheter Use in Adult Acute Care: A Systematic Review.

This systematic review evaluated interventions aimed at reducing peripheral intravenous catheter (PIVC) use in adult acute care settings.

Emerg Med AustralasSep 30, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Integration of artificial intelligence into pharmacovigilance: A systematic review.

This systematic review mapped artificial intelligence and machine-learning applications in post-marketing pharmacovigilance, drawing on 67 studies identified through searches of eight databases and supplementary…

Res Social Adm PharmSep 30, 2026Read summary
Case ReportNeurologyOpen access

Stroke mimic caused by severe hypomagnesemia: a case report and literature review.

A patient with a history of transient neurological deficits presented with stroke-like symptoms, including hemiparesis and aphasia. The patient was on Proton Pump Inhibitors and Metformin.

J NeurolSep 29, 2026Read case
Clinical ResearchEndocrinology

Contemporary Initial Glucose-Lowering Strategies for Type 2 Diabetes: A Systematic Review and Bayesian Network Meta-Analysis.

This systematic review and Bayesian random-effects network meta-analysis compared initial glucose-lowering strategies in treatment-naïve adults with type 2 diabetes or after adequate washout.

Diabetes Obes MetabSep 29, 2026Read summary
Case ReportPulmonology

Reversible bilateral cerebellar ataxia resulting from hypercapnic encephalopathy in an undiagnosed patient with obstructive sleep apnoea.

A man in his 40s with morbid obesity and type 2 diabetes presented with early-morning drowsiness and respiratory distress after nocturnal dyspnoea and diuretic use.

BMJ Case RepSep 28, 2026Read case
Case ReportNeurology

Coexisting Postural Orthostatic Tachycardia Syndrome on Autonomic Reflex Testing in Functional Neurologic Disorder.

An 18-year-old woman with a prior diagnosis of functional neurological disorder (FND) presented with fluctuating lower-extremity weakness, gait disturbance, and recurrent drop attacks, alongside persistent orthostatic…

Am J Case RepSep 28, 2026Read case
Clinical ResearchEndocrinologyOpen access

Non-thyroidal illness syndrome and isolated low triiodothyronine as prognostic markers in acute illness: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the relationship between thyroid hormone alterations and mortality in critically ill and cardiovascular patients.

EndocrineSep 28, 2026Read summary
Clinical ResearchEndocrinologyOpen access

Effects of concurrent training sequence on cardiometabolic risk factors in patients with type 2 diabetes: a systematic review and network meta-analysis.

This systematic review and network meta-analysis evaluated the effects of concurrent training sequences on cardiometabolic risk factors in patients with type 2 diabetes mellitus (T2DM).

EndocrineSep 28, 2026Read summary
Case ReportOphthalmology

Non-Arteritic Anterior Ischaemic Optic Neuropathy Associated with Semaglutide use.

A woman in her 70s with vascular risk factors presented with a three-day history of progressive left-sided visual disturbance. Examination revealed a left relative afferent pupillary defect and inferior quadrantopia.

Ir Med JSep 28, 2026Read case
Clinical ResearchNephrology

A secondary analysis of the SODa-BIC randomized clinical trial using multiple hierarchical composite outcomes.

This post-hoc analysis of the SODa-BIC randomized trial evaluated the effects of sodium bicarbonate on Major Adverse Kidney Events at 30 days in critically ill patients with metabolic acidosis.

Crit Care SciSep 28, 2026Read summary
Clinical ResearchPulmonology

Early cardiovascular vulnerability after acute exacerbation of COPD: a time-windowed systematic review and evidence map.

This systematic review and evidence map examined cardiovascular events during and after exacerbations of COPD, asthma, or bronchiectasis, with COPD as the primary evidence base.

Respir MedSep 26, 2026Read summary
Clinical ResearchInternal Medicine (General)

Within-person variability and the minimal important difference of the EQ-VAS in adults with post-COVID-19 condition: a secondary analysis of data from a single-centre randomised controlled trial.

This secondary analysis of a randomized controlled trial evaluated the EuroQol Visual Analogue Scale (EQ-VAS) in adults with post-COVID-19 condition (PCC).

BMJ OpenSep 25, 2026Read summary
Clinical ResearchEndocrinology

Blood pressure targets for hypertension in people with diabetes mellitus.

This Cochrane systematic review protocol aims to evaluate whether lower blood pressure targets (≤ 130/85 mmHg) reduce mortality and morbidity compared to standard targets (≤ 140 to 160/90 to 100 mmHg) in individuals…

Cochrane Database Syst RevSep 25, 2026Read summary
Clinical ResearchPsychiatry

Multimorbidity and the risk of depression: a systematic review of cohort studies.

This systematic review evaluated the longitudinal association between multimorbidity and the risk of developing depression, analyzing 17 cohort studies.

J Glob HealthSep 25, 2026Read summary
Clinical ResearchCardiology

The reduction in blood pressure required to reduce arterial stiffness components in SPRINT: a randomized controlled trial.

This analysis of the multicentre SPRINT randomised controlled trial examined whether blood pressure changes were associated with changes in arterial stiffness components over 1 year.

Am J Physiol Heart Circ PhysiolSep 25, 2026Read summary
Clinical ResearchCardiology

Opposite seasonal variation in nighttime and morning blood pressure: a longitudinal study of patients with hypertension.

This longitudinal study examined seasonal variations in nighttime and morning blood pressure (BP) among 419 hypertensive patients using home blood pressure monitoring.

Am J HypertensSep 24, 2026Read summary
Case ReportRheumatology

Takayasu arteritis manifesting as pyrexia of unknown origin and massive splenomegaly.

A male patient in his early 20s presented with a three-month history of pyrexia of unknown origin, significant weight loss, a left carotid bruit, and massive splenomegaly.

BMJ Case RepSep 24, 2026Read case
Clinical ResearchInternal Medicine (General)

Clinical Surveillance Technologies in Nonintensive Care Unit Hospital Settings: Systematic Review and Bayesian Network Meta-Analysis of Randomized Trials.

This systematic review and Bayesian network meta-analysis evaluated the clinical effects of rule-based electronic surveillance (RB-ES), predictive model-based electronic surveillance (PM-ES), and continuous physiologic…

J Med Internet ResSep 24, 2026Read summary
Clinical ResearchInternal Medicine (General)

Feasibility of an interdisciplinary primary care-based intervention to improve care transitions for hospitalized patients with substance use disorders: The IntACT pilot randomized controlled trial protocol.

The IntACT pilot study is a single-site randomized controlled trial assessing the feasibility and preliminary effectiveness of a primary care-based intervention for hospitalized patients with substance use disorders…

PLoS OneSep 24, 2026Read summary

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