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2000 articles
September 202624
Molecularly Guided Therapy Versus Continued Chemotherapy in Unfavorable Cancer of Unknown Primary: Updated Efficacy and Safety From the Randomized, Phase II CUPISCO Study.
This updated analysis of the multicenter, randomized phase II CUPISCO trial compared molecularly guided therapy (MGT), selected after comprehensive genomic profiling, with continued platinum-based chemotherapy in…
Prostate lymphoma uncovered during urological encounters: Diagnostic challenges and clinical outcomes in a case series with systematic review of the literature.
Prostatic lymphoma is a rare malignancy that can clinically resemble benign prostatic hyperplasia (BPH) or adenocarcinoma, often delaying diagnosis.
Multidisciplinary Rehabilitation Following Upper Gastrointestinal Cancer Surgery (RESTORE II): A Definitive Randomized Controlled Trial.
RESTORE II was a randomized controlled trial comparing a 12-week multidisciplinary rehabilitation program with standard care in disease-free patients at least 3 months after upper gastrointestinal cancer resection.
Use of indocyanine green fluorescence versus patent blue V dye for sentinel lymph node biopsy in early breast cancer, a randomized controlled trial.
This randomized controlled trial compared indocyanine green (ICG) fluorescence with patent blue V (PBV) dye for sentinel lymph node biopsy in 40 patients with early-stage, node-negative breast cancer.
Exploring disparities in adherence to colorectal cancer clinical practice guidelines and associated survival outcomes: a systematic review and meta-analysis.
This systematic review and meta-analysis examined adherence to colorectal cancer clinical practice guidelines (CPGs) and its impact on survival outcomes.
Robotic-assisted versus video-assisted thoracoscopic anatomical lung resection for early-stage non-small cell lung cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis compared robotic-assisted thoracic surgery (RATS) and video-assisted thoracoscopic surgery (VATS) for anatomical lung resection in early-stage non-small cell lung cancer (NSCLC).
A systematic review and network meta-analysis of first-line EGFR-TKI-based combination strategies for EGFR-mutant non-small cell lung cancer with brain metastases.
This systematic review and network meta-analysis evaluated the efficacy and safety of first-line EGFR-TKI-based combination strategies in patients with EGFR-mutant non-small cell lung cancer and brain metastases.
Functional Renal Assessment via Dynamic LAFOV 18 F-FDG PET/CT in a Patient with Recurrent Extranodal Marginal-Zone Lymphoma.
A 72-year-old man with recurrent extranodal marginal-zone B-cell lymphoma underwent dynamic long-axial-field-of-view 18 F-FDG PET/CT.
Biopsy-proven kidney-limited thrombotic microangiopathy associated with bevacizumab and pegylated liposomal doxorubicin: a case with a biphasic clinical course.
A 52-year-old woman with metastatic ovarian serous adenocarcinoma developed kidney-limited thrombotic microangiopathy (TMA) during treatment with bevacizumab and pegylated liposomal doxorubicin (PLD).
[ 68 Ga]-DOTATATE PET Standardized Uptake Value Reduction after Bevacizumab in High-grade Meningioma: A Potential Treatment Response Biomarker.
Three patients with biopsy-confirmed World Health Organization grade 3 meningioma received bevacizumab therapy and underwent baseline and follow-up [68 Ga]-DOTATATE PET imaging.
Co-Occurring EGFR L858R Mutation and HER2 Amplification in NSCLC Identified by Stepwise Molecular Profiling.
A 54-year-old non-smoking woman with Stage IIIA lung adenocarcinoma initially tested negative for EGFR mutations. After disease progression and severe chemotherapy toxicity, stepwise molecular profiling revealed HER2…
Effects of erector spinae plane block on postoperative pain in patients undergoing implant-based breast reconstruction for breast cancer: a randomized controlled trial.
This randomized controlled trial evaluated the impact of a single-shot T5 erector spinae plane block (ESPB) on postoperative pain in 100 adults undergoing implant-based breast reconstruction.
Bifidobacterium animalis subsp. lactis V9 overcomes CYFRA 21-1-linked immunochemotherapy resistance in NSCLC via microbial metabolites.
This randomized controlled trial investigated the effects of Bifidobacterium animalis subsp. lactis V9 on immunochemotherapy resistance in patients with advanced non-small cell lung cancer (NSCLC) linked to elevated…
PCa Detection in PI-RADS 4 and 5 Lesions: Comparison of [ 68 Ga]Ga-PSMA-11 PET/CT-Guided Robot-Assisted Biopsy Versus mpMRI Cognitive-Fusion TRUS-Guided Prostate Biopsy.
This randomized controlled trial compared the diagnostic performance of robotic arm-assisted [68Ga]Ga-PSMA-11 PET/CT-guided prostate biopsy (PGPB) with mpMRI-directed cognitive-fusion transrectal ultrasound-guided…
Durvalumab-associated nephrotic syndrome and organizing pneumonia: a case report.
A 68-year-old man with unresectable advanced non-small cell lung cancer developed nephrotic syndrome and organizing pneumonia after starting durvalumab therapy.
Subtyping limited stage small cell lung cancer (LS SCLC) reveals inflammatory subtypes with improved chemoradiotherapy outcomes.
This molecular subtype analysis examined baseline tumor gene-expression samples from participants in a randomized trial of concurrent chemoradiotherapy for limited-stage small cell lung cancer (LS SCLC).
Pediatric T-cell lymphoblastic lymphoma with t(9;17)(q34;q23)-associated N-terminally truncated NOTCH1 activation: a case report.
A 6-year-old boy presented with T-cell lymphoblastic lymphoma (T-LBL). Testing identified a t(9;17)(q34;q23) translocation producing a MIR142HG::NOTCH1 fusion and a truncated, constitutively active NOTCH1 protein.
Ifebemtinib plus garsorasib in previously treated metastatic colorectal cancer with KRAS G12C mutation: a multicentre, randomised, phase 1b/2 trial.
This multicentre, randomised phase 1b/2 trial evaluated the combination of ifebemtinib and garsorasib in patients with previously treated metastatic colorectal cancer harboring the KRAS G12C mutation.
Adjuvant alectinib versus chemotherapy in resected ALK-positive non-small-cell lung cancer (ALINA): health-related quality-of-life and safety outcomes from a randomised, open-label, phase 3 trial.
The ALINA trial, a phase 3 randomized controlled trial, evaluated adjuvant alectinib versus chemotherapy in patients with resected ALK-positive non-small-cell lung cancer (NSCLC).
Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial.
The HARMONi trial evaluated the efficacy and safety of ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after progression on EGFR TKI…
Durvalumab and tremelimumab, with or without lenvatinib, combined with transarterial chemoembolisation in participants with embolisation-eligible hepatocellular carcinoma (EMERALD-3): a global, randomised, open-label, sponsor-blinded, phase 3 study.
The EMERALD-3 study evaluated the efficacy and safety of combining STRIDE (tremelimumab and durvalumab) with or without lenvatinib and transarterial chemoembolisation (TACE) in patients with embolisation-eligible…
Sexual dysfunction outcomes and reporting disparities after multimodal treatment for rectal cancer: A systematic review and narrative synthesis.
This systematic review evaluated sexual dysfunction outcomes after rectal cancer treatment, highlighting significant reporting disparities between sexes.
Manual, digital, and AI tumour-infiltrating lymphocyte scoring: a secondary analysis of the APHINITY randomised trial.
This secondary analysis of the phase 3 APHINITY trial evaluated manual, digital, and AI-based scoring of stromal tumour-infiltrating lymphocytes (sTILs) in 4262 patients with early-stage HER2-positive breast cancer.
First-line anlotinib versus bevacizumab plus CapeOX in RAS/BRAF wild-type unresectable metastatic colorectal cancer (ANCHOR): a multicenter, prospective, randomized, phase 3 trial.
The ANCHOR trial, a multicenter, prospective, randomized phase 3 study, compared first-line anlotinib with bevacizumab plus CapeOX in patients with RAS/BRAF wild-type unresectable metastatic colorectal cancer.
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