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1357 articles

October 202624

Clinical ResearchEndocrinology

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes.

This analysis examined whether baseline serum metabolites could predict response to teplizumab in 41 people newly diagnosed with type 1 diabetes who participated in the randomized AbATE trial.

DiabetesOct 21, 2026Read summary
Clinical ResearchOphthalmology

EVALUATING THE EFFICACY AND SAFETY OF TOPICAL DIFLUPREDNATE IN PATIENTS WITH CHRONIC CENTRAL SEROUS CHORIORETINOPATHY.

This pilot, open-label randomized controlled trial compared topical difluprednate, oral eplerenone, and observation in adults with chronic or relapsing central serous chorioretinopathy.

RetinaOct 21, 2026Read summary
Clinical ResearchEndocrinology

Evaluating Improvement in Pain and Sensory Function When Using High-Frequency (10-kHz) Spinal Cord Stimulation in Individuals With Painful Diabetic Neuropathy: A Multicenter Randomized Controlled Trial (PDN-Sensory).

The multicenter randomized controlled PDN-Sensory trial evaluated 10-kHz spinal cord stimulation (SCS) plus conventional medical management (CMM) versus CMM alone in people with painful diabetic neuropathy.

Diabetes CareOct 21, 2026Read summary
Clinical ResearchCardiologyOpen access

Effectiveness and safety of atorvastatin/ ezetimibe fixed-dose combination in hypercholesterolemia: a systematic review and network meta-analysis.

This systematic review and network meta-analysis compared atorvastatin alone with atorvastatin/ezetimibe free-equivalent and fixed-dose combinations in people with hypercholesterolemia.

PeerJOct 21, 2026Read summary
Clinical ResearchOncology (Medical)

Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial.

This single-arm, multicentre phase 2 trial assessed neoadjuvant ipilimumab plus nivolumab followed by surgery in previously untreated patients with resectable stage 2 or 3 mismatch repair-deficient colon cancer.

LancetOct 21, 2026Read summary
Clinical ResearchInfectious Diseases

Impact of violence on HIV outcomes among female sex workers: A global systematic review and meta-analysis.

This global systematic review and meta-analysis examined associations between violence and HIV outcomes among female sex workers (FSW). It included 94 studies, 226 estimates and 186,613 FSWs across 39 countries.

PLoS MedOct 21, 2026Read summary
Clinical ResearchOphthalmology

EFFICACY AND SAFETY OF SUBTHRESHOLD LASER IN PATIENTS WITH ACUTE CENTRAL SEROUS CHORIORETINOPATHY: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis assessed the efficacy and safety of subthreshold laser for acute central serous chorioretinopathy (CSC), including six randomized controlled trials with 401 participants.

RetinaOct 21, 2026Read summary
Clinical ResearchPediatrics

The impact of recreational beach tennis associated with nutritional counseling on cardiometabolic risk factors in adolescents: a randomized clinical trial.

This 12-week randomized clinical trial compared recreational beach tennis alone with beach tennis plus nutritional counseling in 40 adolescents aged 11–14 years.

Arch Endocrinol MetabOct 20, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Comparative perioperative and oncological outcomes of the da Vinci Xi versus Si robotic surgical systems in rectal cancer surgery: a systematic review and meta-analysis.

This systematic review and meta-analysis compared perioperative and oncological outcomes with da Vinci Xi versus Si systems in rectal cancer surgery.

J Robot SurgOct 20, 2026Read summary
Clinical ResearchPsychiatry

Stage-dependent gray matter morphological alterations across the clinical spectrum of depressive disorder.

This quantitative voxel-wise meta-analysis examined gray matter volume (GMV) patterns across subthreshold depression, first-episode drug-naïve depression, and long-term major depressive disorder, comparing each group…

J Affect DisordOct 20, 2026Read summary
Clinical ResearchPsychiatry

The effects of an online mindfulness-based intervention for parents of children with attention deficit/hyperactivity disorder.

This two-arm randomized controlled trial compared an online mindfulness-based intervention (MBI) with online psychoeducation in 248 parents of children aged 6 to 12 years with ADHD symptoms.

J Affect DisordOct 20, 2026Read summary
Clinical ResearchRheumatologyOpen access

The Effect of Mindfulness-Based Cognitive Therapy on Kinesiophobia in Older Adults with Chronic Knee Osteoarthritis: A Randomized Controlled Trial.

This randomized controlled trial evaluated mindfulness-based cognitive therapy (MBCT) for kinesiophobia in 56 older adults with chronic knee osteoarthritis in Kashan, Iran.

Clin Interv AgingOct 20, 2026Read summary
Clinical ResearchGeriatricsOpen access

Optimizing exercise prescriptions for older adults with mild cognitive impairment: a dose-response network meta-analysis of modality-dose combinations on executive function.

This Bayesian dose-response network meta-analysis synthesized randomized controlled trials of repeated exercise programmes in adults aged 60 years or older with mild cognitive impairment.

PeerJOct 20, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Selective recovery effects of short-term beetroot juice supplementation after exercise-induced muscle damage in trained female volleyball players.

This randomized, double-blind, placebo-controlled crossover trial examined short-term beetroot juice (BRJ) supplementation after exercise-induced muscle damage in trained female university volleyball players.

J Int Soc Sports NutrOct 20, 2026Read summary
Clinical ResearchObstetrics & GynecologyOpen access

Effectiveness and safety of adjunct interventions for external cephalic version in breech presentation: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed adjunct and procedural strategies for external cephalic version (ECV) in pregnant women with breech presentation, drawing on 10 randomised controlled trials with 2,745…

Rev Bras Ginecol ObstetOct 20, 2026Read summary
Clinical ResearchPediatrics

Resistance Exercise for Body Composition in Children Who Are Overweight or Obese.

This systematic review and meta-analysis examined randomized controlled trials of resistance-based exercise in children and adolescents classified as overweight or obese.

Pediatr Exerc SciOct 20, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Placebo effects of caffeine on sport performance: a systematic review and meta-analysis.

This systematic review and meta-analysis examined whether deceptively describing a placebo as caffeine affects sport performance in healthy adults.

J Int Soc Sports NutrOct 20, 2026Read summary
Clinical ResearchPsychiatry

Complex post-traumatic stress disorder in refugees, asylum seekers, and internally displaced people: a systematic review and meta-analysis.

This systematic review and random-effects meta-analysis examined complex post-traumatic stress disorder (CPTSD) prevalence among refugees, asylum seekers, and internally displaced people.

Eur J PsychotraumatolOct 20, 2026Read summary
Clinical ResearchHematology

Challenges of Conducting a Feasibility Pilot Randomized Controlled Trial During COVID-19 Restrictions: Rivaroxaban Versus Acetyl Salicylic Acid in Patients with Multiple Myeloma on Lenalidomide-Based Therapy (RithMM).

This multicentre pilot randomised controlled trial assessed whether a full-scale comparison of rivaroxaban and acetylsalicylic acid for thromboprophylaxis was feasible in patients with multiple myeloma receiving…

Curr OncolOct 20, 2026Read summary
Clinical ResearchPulmonologyOpen access

Effects of resistance training on subjective sleep quality, excessive daytime sleepiness, and quality of life in patients with obstructive sleep apnea: a secondary analysis from a randomized controlled trial.

This secondary analysis of a randomized controlled trial examined eight weeks of resistance training in 25 adults with moderate to severe obstructive sleep apnea.

Sleep BreathOct 20, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Combination of oral fluoropyrimidines and EGFR-directed antibodies in frail patients with metastatic colorectal cancer: a systematic review.

This systematic review assessed phase II and III evidence for oral fluoropyrimidines combined with EGFR-directed antibodies in patients with RAS wild-type metastatic colorectal cancer, including those considered unfit…

J Cancer Res Clin OncolOct 20, 2026Read summary
Clinical ResearchNeurology

Interventions Supporting Functional Recovery After Traumatic Brain Injury in Public Safety Personnel: A Systematic Review of Outcomes and Work Reintegration Considerations.

This systematic review synthesized evidence on interventions for functional recovery and return to work (RTW) among public safety personnel (PSP) with traumatic brain injury.

J Head Trauma RehabilOct 20, 2026Read summary
Clinical ResearchPreventive Medicine / Public HealthOpen access

Mixture of Plasticizer Chemicals and Child Intelligence: A Weight-of-Evidence and Meta-Analysis-Informed Bayesian Approach in a Cohort with Improved Exposure Assessment.

This cohort study examined prenatal and infant exposure to plasticizer chemicals and IQ at age 3 among 380 mother-infant pairs in the French SEPAGES study.

Environ Health PerspectOct 20, 2026Read summary
Clinical ResearchGeneral Surgery

The Clinical Significance of Hyperkinetic Biliary Dyskinesia on HIDA Scan: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis assessed outcomes after cholecystectomy in patients with biliary-type pain and gallbladder ejection fraction (EF) ≥80% on CCK-stimulated HIDA scans.

Clin Nucl MedOct 20, 2026Read summary

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