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1357 articles
October 202624
Efficacy and safety of interactive digital therapeutics with cognitive behavioral therapy for depressive symptoms in patients with major depressive disorder: A multicenter, randomized, assessor-blinded trial versus an active mood diary control.
This multicenter, randomized, assessor-blinded 8-week trial compared interactive digital cognitive behavioral therapy (iDT-CBT) with an active mood diary in 110 adults with major depressive disorder.
Acetic acid chromoendoscopy for detection of neoplastic Barrett's oesophagus: stepped wedge cluster randomised controlled trial (ACID-trial).
This prospective, open-label, stepped-wedge cluster randomised trial assessed whether acetic acid chromoendoscopy (AAC) improved detection of dysplasia or oesophageal adenocarcinoma during Barrett’s oesophagus…
Sevuparin in children with severe malaria: a phase I safety and dose-finding trial.
This phase I dose-finding trial assessed sevuparin safety and tolerability in Kenyan and Zambian children with severe malaria.
Outcomes of Mindful Mood Balance for Moms, online mindfulness-based cognitive therapy for perinatal depressive relapse prevention in the USA: a two-arm, single-blind, pragmatic randomised clinical trial.
This single-blind, pragmatic randomised clinical trial tested a web-based mindfulness-based cognitive therapy programme plus usual care against usual care alone in euthymic pregnant women with recurrent depression and…
A multifaceted intervention to increase bystander CPR rates after out-of-hospital cardiac arrest in France: a stepped-wedge, cluster-randomised, controlled trial.
This stepped-wedge, cluster-randomised controlled trial assessed a coordinated intervention to increase bystander CPR before EMS arrival among adults with non-traumatic out-of-hospital cardiac arrest in France.
Feasibility of a multidimensional interdisciplinary rehabilitation program for people with dementia and their informal primary caregivers - a randomized pilot trial with a caregiver focus.
This randomized pilot trial assessed the feasibility of a person-centred, interdisciplinary rehabilitation program for community-dwelling people with dementia that also provided education and support to informal…
Real-world safety and efficacy of lecanemab in the treatment of Alzheimer's disease: a systematic review and meta-analysis.
This systematic review and meta-analysis pooled real-world studies of lecanemab treatment in people with Alzheimer’s disease, including 37 studies.
Association between rheumatic diseases and glaucoma risk: a systematic review and meta-analysis of 5.7 million individuals.
This systematic review and meta-analysis examined glaucoma occurrence and risk among people with rheumatic diseases (RD), drawing on 18 studies with 5,766,143 participants.
Effects of Aerobic Exercise on Autonomic and Endothelial Function and Splanchnic Hemodynamics in Compensated Cirrhosis: RCT Study.
This parallel-group randomised controlled trial assessed 16 weeks of moderate-intensity aerobic exercise plus nutritional consultation versus nutritional consultation alone in 50 sedentary patients with compensated…
"The Effect of Forgiveness Psychoeducation on Death Anxiety, Caregiver Burden, and Forgiveness Tendencies in Caregivers of Patients at the End of Life: A Randomized Controlled Trial": Şahin 49(3) May/June 2026.
This randomized controlled trial evaluated forgiveness psychoeducation for 56 caregivers of patients at the end of life, with 28 assigned to the intervention and 28 to a no-intervention control group.
Phase 2 trial to evaluate the safety and immunogenicity of a 25-valent pneumococcal conjugate vaccine (IVT-PCV25) in infants.
This double-blind, randomised phase 2 trial in 421 healthy infants in the Philippines compared three dose-ranging formulations of the 25-valent pneumococcal conjugate vaccine IVT-PCV25 with licensed Prevnar-20.
Evaluating a multi-vaccine respiratory immunization strategy involving SARS-CoV-2, pneumococcal, and influenza vaccines in adults: A randomized, open-label, multicenter, controlled, non-inferiority Phase IV trial in China.
This randomized, open-label, multicenter Phase IV trial in China assessed immunogenicity and safety when adults aged ≥18 years received an inactivated SARS-CoV-2 vaccine with PPV23 and IIV4, compared with separate…
Direct and indirect entomological efficacy of Targeted Indoor Residual Spraying against Aedes aegypti in Iquitos, Peru.
This entomological cluster-randomized controlled trial in Iquitos, Peru, compared targeted indoor residual spraying (TIRS) with standard Ministry of Health vector-control activities.
From Alert to Action: Electronic Practice Advisory Improves DSMES Referrals Over 18 Months.
This cluster-randomized controlled trial in primary care practices in central North Carolina tested whether an electronic health record best practice advisory (BPA) increased referrals to diabetes self-management…
Weight loss during intermittent fasting, not Mediterranean diet quality alone, is associated with lower inflammation: A randomized controlled trial.
This 16-week randomized controlled-feeding trial studied 53 adults with metabolic risk factors assigned to a provided Mediterranean diet or their habitual western diet, with twice-weekly fasting added after 8 weeks.
The Effect of Obesity on the α-Cell Response to Hyperglycemia in the Presence of Amino Acids.
This randomized, two-occasion study examined how amino acids affect glucagon suppression during graded glucose infusion in lean participants and participants with obesity, with or without hepatic steatosis.
The Improvement in the Clinical Management of Patients Undergoing Palliative Care After Training the Primary Care Team by a Specialized Team: A Systematic Review.
This systematic review assessed whether palliative care training for healthcare professionals in primary care improves symptom assessment and clinical management. Eight studies with varied designs were included.
Additional Functional Exercise Training Improves Knee Recovery After Meniscus Repair: A Randomized Controlled Trial.
This prospective randomized controlled trial assessed whether functional exercise training (FET) added to conventional rehabilitation improves recovery after meniscus repair.
Thermographic outcomes of auricular laser acupuncture and auricular seed acupressure in older adults with chronic shoulder pain: an exploratory nonrandomized, nonconcurrent comparison.
This exploratory, open-label, nonrandomized comparison studied 20 adults aged 60–90 years with chronic shoulder pain, allocated by order of entry to auricular laser acupuncture or seed acupressure.
Extended Ceftriaxone Prophylaxis and Postoperative Inflammation and Infection-Related Symptoms After Ureteral Lithotripsy with Negative Urine Cultures.
This single-center exploratory study, reported as randomized, compared extended preoperative ceftriaxone with a single prophylactic dose in 252 patients with negative urine cultures undergoing rigid ureteroscopic…
Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial.
MIRA2 was a multicentre, open-label, randomised controlled superiority trial in women younger than 60 years with heavy menstrual bleeding eligible for endometrial ablation.
Bronchial Thermoplasty in Severe Asthma: Bridging Randomised and Real-World Evidence: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed bronchial thermoplasty (BT) efficacy and safety in adults with severe uncontrolled asthma, analysing randomised controlled trials (RCTs) separately from observational…
ULTRAWIDE-FIELD COLOR FUNDUS IMAGES AND ARTIFICIAL INTELLIGENCE FOR DIAGNOSIS OF DIABETIC RETINOPATHY: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed artificial intelligence (AI) for diabetic retinopathy (DR) evaluation using ultrawide-field fundus images.
Calorie-Restricted DASH, Carbohydrate-Restricted, and Low-Purine Diets for Weight Loss and Urate Control in Men With Overweight or Obesity and Hyperuricemia: A Randomized Trial.
This 12-week, open-label, active-comparator randomized trial compared calorie-restricted carbohydrate-restricted, DASH, and low-purine balanced diets in 102 men with overweight or obesity and hyperuricemia.
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