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1357 articles
October 202624
Outcomes of Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke Due to Cardioembolism: A Secondary Analysis of the POST-UK Trial.
This secondary analysis of the multicenter, randomized POST-UK trial assessed adjunctive intra-arterial urokinase after near-complete to complete reperfusion in patients with acute ischemic stroke due to cardioembolism.
Skeletal effects of GLP-1 receptor agonist therapy in adults with overweight or obesity: a systematic review.
This systematic review examined randomized evidence on bone mineral density (BMD) and bone-turnover markers in adults with overweight or obesity receiving GLP-1 receptor agonists.
Impact of YAQ001 on the Gut Microbiome, Permeability and Markers of Systemic Inflammation in Patients With Cirrhosis.
This double-blind randomised controlled substudy examined YAQ001’s effects on the gut microbiome and exploratory markers of gut permeability and systemic inflammation in 28 patients with cirrhosis.
Feasibility of a Co-Designed Personalized Cognitive Reablement Program Delivered via Digital Voice Assistants for Older Adults Living With Early-Stage Dementia or Mild Cognitive Impairment: Pilot Randomized Controlled Trial.
This nonblinded pilot randomized controlled trial assessed the feasibility and potential effectiveness of VOICE-COG, a personalized cognitive reablement program delivered through digital voice assistants, in adults aged…
Evaluation of the Achievement of a Pharmacodynamic Target of Piperacillin-Tazobactam for the Population With Obesity: An Open Randomized Controlled Feasibility Study (TAZO-OBESITY Trial).
The open-label randomized feasibility trial TAZO-OBESITY compared standard with prolonged piperacillin-tazobactam infusions in patients with obesity (BMI ≥30 kg/m²).
Effects of E-Coach-Based Chronic Disease Management on Self-Management, Quality of Life, and Mental Health in Maintenance Hemodialysis Patients.
This randomized controlled trial evaluated a WeChat-based E-Coach programme in 96 patients receiving maintenance hemodialysis, comparing usual care plus E-Coach with usual care alone.
Adjunctive Oliceridine During Propofol or Ciprofol Sedation for Same-Session Bidirectional Endoscopy in Older Adults: A Multicenter Randomized 2×2 Factorial Trial.
This multicenter, double-blind, placebo-controlled 2×2 factorial randomized trial assessed adjunctive oliceridine with propofol or ciprofol for same-session bidirectional endoscopy in adults aged 65–80 years.
Jidesheng Snake Pills as Adjunctive Therapy for Snakebite: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis assessed randomized evidence for Jidesheng Snake Pills as adjunctive treatment for snakebite. Five unique trials involving 458 participants were included.
The entorhinal cortex atrophy score for diagnostic distinction between phases of the Alzheimer's disease continuum.
This systematic review assessed the Entorhinal Cortex Atrophy (ERICA) visual score for distinguishing subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s disease (AD) dementia.
Efficacy and Safety of Pharmacologic Therapies in Nonobstructive Hypertrophic Cardiomyopathy: A Systematic Review.
This systematic review synthesized prospective interventional studies of pharmacologic therapies in adults with nonobstructive hypertrophic cardiomyopathy (HCM).
Evaluation of Acute Electrical and Hemodynamic Improvement During Left Bundle-Branch Area Pacing Modalities for Resynchronization Therapy.
This prospective, within-subject physiological study assessed acute electrical and hemodynamic responses to four pacing modalities in 24 patients with heart failure with reduced ejection fraction and left bundle-branch…
Role of Plasma Proteins in the Association Between Socioeconomic Status and Cardiovascular Disease Events: Results From Trans-Omics for Precision Medicine Cohorts.
This meta-analysis examined socioeconomic status (SES), plasma proteins, and incident coronary heart disease (CHD) and stroke in participants from three cohorts.
Interim Analysis of a Phase 3 Trial of Povetacicept in IgA Nephropathy.
This prespecified interim analysis of an ongoing, multicenter, phase 3 randomized, double-blind, placebo-controlled trial evaluated povetacicept in participants with biopsy-proven IgA nephropathy receiving stable…
A Methodological Framework for a Large Language Model Virtual Companion for Older Adults at Risk of Social Isolation.
This paper presents a methodological framework for developing and evaluating a large language model (LLM)-driven virtual companion for older adults at risk of social isolation.
The role of sexual mindfulness in enhancing sexual well-being among breast cancer survivors: A randomized clinical trial.
This randomized clinical trial assessed sexual mindfulness training for sexual well-being among women with breast cancer attending health service centers in Shahrekord, Iran.
The Impact of Telemedicine Interventions on Maternal and Fetal Outcomes in Women With Gestational Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis pooled 23 randomized controlled trials involving 3055 women with gestational diabetes to assess telemedicine and maternal and fetal outcomes.
Platelet-rich plasma for knee osteoarthritis: a systematic review and meta-analysis of structural outcomes.
This systematic review and meta-analysis assessed imaging-based structural outcomes after platelet-rich plasma (PRP) treatment in people with knee osteoarthritis.
Drug-coated balloons in coronary disease: meta-analysis comparing sirolimus- and paclitaxel-coated technologies.
This systematic review and meta-analysis compared sirolimus-coated balloons (SCBs) with paclitaxel-coated balloons (PCBs) for coronary interventions.
Molecular-genetic mechanisms of cerebral arteriovenous malformations: A systematic review of germline, somatic and experimental evidence.
This systematic review synthesised human genetic, molecular, and experimental evidence on cerebral arteriovenous malformation (AVM) formation, clinical course, and potential therapeutic targets.
Agreement Between In-Person and Telephone Application of the Informant Questionnaire on Cognitive Decline in the Elderly.
This methodological study assessed agreement between in-person and telephone administration of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), completed by caregivers or family members of older…
Prediction of death by neurologic criteria in patients with non-traumatic acute brain injury: a systematic review and meta-analysis.
This systematic review and meta-analysis examined predictors of death by neurologic criteria (DNC) after non-traumatic acute brain injury.
Wireless Home Blood Pressure Monitoring With Health Coaching for Hypertension Management at a Federally Qualified Health Center: Pilot Randomized Controlled Feasibility and Acceptability Study.
This 6-month, two-arm randomized pilot trial assessed feasibility and acceptability of wireless home blood pressure monitoring (HBPM) with health coaching among adults with uncontrolled or newly diagnosed hypertension…
Early exercise therapy for acute nephrotic syndrome: a randomised clinical trial.
This single-centre randomised controlled trial assessed early exercise therapy in hospitalised adults receiving glucocorticoids for acute nephrotic syndrome.
Firstline treatment with ruxolitinib versus best available therapy in patients with polycythemia vera: results from the randomized RuxoBEAT trial.
The multicenter randomized RuxoBEAT trial compared first-line ruxolitinib (RUX) with best available therapy (BAT) in patients with polycythemia vera.
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