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1357 articles

October 202624

Clinical ResearchGastroenterology

Gut virome remodeling after fecal microbiota transplantation is associated with virus-bacteria co-variation and metabolic response in obesity and type 2 diabetes.

This randomized controlled trial examined longitudinal fecal virome and bacteriome changes after fecal microbiota transplantation (FMT) in people with obesity and type 2 diabetes.

Gut MicrobesOct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Effect of Danggui Buxue Medicinal Diet on cancer-related fatigue in anemic colon cancer patients undergoing chemotherapy: A randomized controlled trial (CONSORT-compliant).

This randomized controlled trial evaluated a 21-day Danggui Buxue Medicinal Diet alongside standard care in patients with chemotherapy-induced anemia after colon cancer surgery.

Medicine (Baltimore)Oct 23, 2026Read summary
Clinical ResearchPhysical Medicine & RehabilitationOpen access

Effects of sensorimotor training combined with short foot exercise on knee and ankle gait kinematics in individuals with flatfoot: A preliminary study.

This preliminary randomized controlled trial compared six weeks of sensorimotor training plus short-foot exercises with sensorimotor training alone in 32 asymptomatic young adults with flexible flatfoot.

Medicine (Baltimore)Oct 23, 2026Read summary
Clinical ResearchPediatricsOpen access

Immediate vs delayed extubation after pediatric liver transplantation: a systematic review and meta-analysis.

This systematic review and meta-analysis compared immediate operating-room extubation with delayed extubation after pediatric orthotopic liver transplantation.

Eur J PediatrOct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Protective effect of N-acetylcysteine on oxaliplatin-induced peripheral neuropathy in colorectal cancer: a randomized controlled trial.

This randomized controlled trial evaluated oral N-acetylcysteine (NAC) for preventing oxaliplatin-induced peripheral neuropathy in 46 patients with stage III or high-risk stage II colorectal cancer receiving adjuvant…

Cancer Chemother PharmacolOct 23, 2026Read summary
Clinical ResearchPhysical Medicine & RehabilitationOpen access

Effects of grip strengthening combined with scapular stabilization exercise on shoulder muscle strength and functional outcomes in individuals with subacromial pain syndrome: A randomized controlled trial.

This randomized controlled trial compared scapular stabilization exercise with the same exercise combined with grip strengthening in 36 individuals with subacromial pain syndrome (SAPS).

Medicine (Baltimore)Oct 23, 2026Read summary
Clinical ResearchNeurologyOpen access

STN-SNr co-stimulation in Parkinson's disease: a systematic review and meta-analysis of motor and freezing-of-gait outcomes.

This systematic review and meta-analysis assessed whether adding substantia nigra pars reticulata stimulation to subthalamic nucleus deep brain stimulation improves motor function or freezing of gait in people with…

Neurol SciOct 23, 2026Read summary
Clinical ResearchDermatology

Balancing safety and efficacy in photodynamic therapy for facial port-wine stains in children aged 2-7 years: a prospective controlled study of light-intensity optimization.

This open-label, prospective controlled study compared two light intensities for hemoporfin-mediated photodynamic therapy in children aged 2–7 years with facial port-wine stains.

J Dermatolog TreatOct 23, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Hematological and biochemical responses to three doses of caffeine during the CrossFit® workout: a randomized, double-blind, crossover trial.

This randomized, double-blind, placebo-controlled crossover trial examined hematological and biochemical responses to caffeine during a 17-minute CrossFit® workout in 26 moderately trained athletes.

J Int Soc Sports NutrOct 23, 2026Read summary
Clinical ResearchPsychiatry

Psychoeducation for posttraumatic stress disorder in adults: a systematic review of formats and delivery approaches.

This systematic review synthesized randomized controlled trials of psychoeducation for adults with PTSD, including interventions delivered alone or as a primary component.

Eur J PsychotraumatolOct 23, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Prophylactic neurectomy versus nerve preservation in open inguinal hernia repair for prevention of chronic postoperative inguinal pain (CPIP): a systematic review and meta-analysis.

This systematic review and meta-analysis assessed prophylactic neurectomy versus nerve preservation in adults undergoing elective open anterior inguinal hernia repair, including 17 randomized trials.

HerniaOct 23, 2026Read summary
Clinical ResearchNephrology

Ravulizumab in IgA Nephropathy - Interim Analysis of a Phase 3 Trial.

This phase 3, multicenter, randomized, placebo-controlled trial evaluated intravenous ravulizumab every 8 weeks in adults with IgA nephropathy and persistent proteinuria despite standard therapy.

N Engl J MedOct 23, 2026Read summary
Clinical ResearchNeurologyOpen access

Lesion Water Content on CT Predicts 12-Month Outcome and Modifies Thrombectomy Effect in Large-Core Stroke-A Secondary Analysis of the TENSION Trial.

This secondary analysis of the randomized TENSION trial examined whether CT-derived net water uptake (NWU) predicts 12-month outcomes and modifies thrombectomy effects in 198 patients with large-core ischemic stroke.

Transl Stroke ResOct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Association between cancer cachexia and treatment-related adverse outcomes in patients with gastrointestinal cancers: a systematic review and meta-analysis.

This systematic review and meta-analysis examined cohort studies of cancer cachexia and treatment-related outcomes in patients with gastrointestinal cancers.

Support Care CancerOct 23, 2026Read summary
Clinical ResearchDermatologyOpen access

Fractional CO₂ laser combined with intradermal and topical platelet-rich plasma for hypertrophic scars: a randomized controlled trial.

This prospective, randomized, assessor-blinded trial compared fractional CO₂ laser plus intradermal and topical platelet-rich plasma (PRP) with laser plus saline in 120 patients with hypertrophic scars.

Lasers Med SciOct 23, 2026Read summary
Clinical ResearchGeriatricsOpen access

Systematic review and meta-analysis of risk factors for oral frailty.

This systematic review and meta-analysis examined factors associated with oral frailty across 14 studies involving 12,297 participants, of whom 4,540 had oral frailty.

Medicine (Baltimore)Oct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Comparative efficacy of common adjuvant treatments after resection of colorectal liver metastases: A systematic review and network meta-analysis.

This systematic review and network meta-analysis compared adjuvant strategies after resection of colorectal liver metastases, including systemic chemotherapy, hepatic arterial infusion chemotherapy (HAIC), and…

Medicine (Baltimore)Oct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Extracorporeal photopheresis for the treatment of steroid-refractory immune related adverse events from immune checkpoint inhibitor therapy: a multi-center phase Ib/II clinical trial.

This prospective, single-arm, non-randomized phase Ib/II multicentre trial evaluated extracorporeal photopheresis (ECP) for steroid-refractory immune-related adverse events (irAEs) in 30 patients receiving immune…

Nat CommunOct 23, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Precancerous cervical lesions and associated factors among HIV-positive women in Southern and Eastern African countries: A systematic review and meta-analysis.

This systematic review and meta-analysis pooled evidence on precancerous cervical lesions (PCCL) and associated factors among women living with HIV in Southern and Eastern Africa.

PLoS OneOct 23, 2026Read summary
Clinical ResearchNeurology

Intra-Arterial Alteplase After Successful Endovascular Reperfusion in Patients Without Intravenous Thrombolysis: A Subgroup Analysis of the PEARL Randomized Clinical Trial.

This prespecified subgroup analysis of the multicenter, randomized PEARL trial examined adjunctive intra-arterial alteplase after successful endovascular thrombectomy in patients with large-vessel occlusion stroke who…

J Am Heart AssocOct 23, 2026Read summary
Clinical ResearchHematologyOpen access

The perceptions of hematopoietic stem cell transplantation decision-making in patients with hematologic malignancies: a qualitative systematic review.

This qualitative systematic review synthesized research on how patients with hematologic malignancies perceive decisions about hematopoietic stem cell transplantation (HSCT).

Support Care CancerOct 23, 2026Read summary
Clinical ResearchEndocrinology

Search for the glycated hemoglobin target minimizing mortality among people with type 2 diabetes with rare incidence of treatment-related severe hypoglycemia - Epidemiologic analysis of J-DOIT3 randomized controlled trial.

This landmark analysis of the J-DOIT3 randomized controlled trial examined associations between updated HbA1c and cardiovascular outcomes or mortality among people with type 2 diabetes, in a setting where severe…

PLoS OneOct 23, 2026Read summary
Clinical ResearchGastroenterologyOpen access

Efficacy and safety of GLP-1 receptor agonists in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH): A systematic review and meta-analysis.

This systematic review and random-effects meta-analysis assessed efficacy and safety of GLP-1 receptor agonists in adults with MASLD or MASH. Nine studies involving 795 participants were included.

Medicine (Baltimore)Oct 23, 2026Read summary
Clinical ResearchNeurologyOpen access

Minocycline in acute stroke: A systematic review and meta-analysis of randomized controlled trials and trial sequential analysis.

This systematic review and meta-analysis pooled randomized controlled trials comparing minocycline with control or standard care in acute ischemic and hemorrhagic stroke.

Medicine (Baltimore)Oct 23, 2026Read summary

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